Drug Delivery Approaches for Doxorubicin in the Management of Cancers

(E-pub Ahead of Print)

Author(s): Manish Vyas, Daniel Albert Simbo, Mohd. Mursalin, Vijay Mishra, Roqia Bashary, Gopal L. Khatik*

Journal Name: Current Cancer Therapy Reviews

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Abstract:

Aim: We aimed to review the drug delivery approaches including novel drug delivery system of doxorubicin as an important anticancer drug.

Background: Doxorubicin is widely used against breast, uterine, ovarian, lung and cervical cancer. It is listed among the essential medicines by WHO and is thus a very important drug that can be used to fight against cancer. Despite its effectiveness, the use of the drug is limited due to its dose-dependent toxicity. Several studies based on the Doxorubicin have been suggesting the need of novel drug delivery formulations in the treatment of malignant and cancerous diseases due to its cytotoxic nature.

Objectives: This review focuses on the different formulations of doxorubicin which is a useful drug in the management of cancers, but associated with toxicity thus these approaches found applicability in the reduction of its toxicity.

Methods: We searched the scientific database using cancer, doxorubicin, and different formulations as the keywords. Here in only peer-reviewed research articles collected which were useful to our current work.

Results: This study is based on examination of the recent advancements of its novel drug delivery formulations. Doxorubicin hydrochloride is the first liposomal anticancer drug, administered via the intravenous route, and also clinically approved for the treatment of lymphomas, leukemias, and solid tumors. Doxorubicin is prepared into a liposomal formulation that contains polyethylene glycol (PEG) layer around doxorubicin containing liposome made by pegylation process. Doxorubicin also formulated in nano-formulations which is also discussed herein led to reduced toxicity and increased efficacy.

Conclusion: In the review, we described the significance of doxorubicin in the form of different delivery approaches in the management cancers with the reduction in the associated toxicity.

Keywords: Doxorubicin, Cancer, Novel formulation, Liposomes, Nanoparticles

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(E-pub Ahead of Print)
DOI: 10.2174/1573394716666191216114950

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