Title:Organocatalytic Combinatorial Synthesis of Quinazoline, Quinoxaline and Bis(indolyl)methanes
VOLUME: 23 ISSUE: 1
Author(s):Fatemeh Malamiri, Samad Khaksar*, Rashid Badri and Elham Tahanpesar
Affiliation:Department of Chemistry, Khouzestan Science and Research Branch, Islamic Azad University, Ahvaz, Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University, Amol, Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz
Keywords:Organocatalyst, green chemistry, quinazoline, multicomponent, heterocyclic, anticancer.
Abstract:
Aims and Objective: An efficient and practical procedure for the synthesis of
heterocyclic compounds such as quinazolines, quinoxalines and bis(indolyl)methanes was
developed using 3,5-bis(trifluoromethyl) phenyl ammonium hexafluorophosphate (BFPHP) as a
novel organocatalyst.
Materials and Methods: All of the obtained products are known compounds and identified by IR,
1HNMR, 13CNMR and melting points.
Result: Various products were obtained in good to excellent yields under reaction conditions.
Conclusion: The BFPHP organocatalyst demonstrates a novel class of non-asymmetric
organocatalysts, which has gained much attention in green chemistry.