Background: Metabolic Syndrome (MS) is a clinical condition consisting of risk factors associated
with type two diabetes and developing cardiovascular disease. It has been suggested that resistin
is a linkage between obesity, inflammation and type two diabetes. This study aims to investigate
whether Resistin Gene (RETN) polymorphism (+62G>A) is linked to MS and resistin levels among
the Egyptian population.
Methods: This study was performed with 310 Egyptian volunteers: 160 MS subjects and 150 controls.
Anthropometric parameters and biochemical variables were determined. The RETN +62G>A polymorphism
was genotyped by PCR-RFLP technique.
Results: The resistin levels of the MS group were significantly higher than those of the control group.
Resistin levels were positively correlated with anthropometric parameters and liver biomarkers in the
MS group. According to RETN +62G>A polymorphism, carriers with the A allele (GA/AA) had significantly
increased resistin levels than subjects with the GG genotype, consequently, the RETN +62G
>A polymorphism was found to be related to MS, biochemical parameters and anthropometric variables.
Conclusion: These findings propose that the RETN +62G>A polymorphism has a great impact on the
circulating resistin concentrations, and that resistin levels are strongly related to MS. Therefore, this
RETN polymorphism is related to the risk of the prevalence of MS in the Egyptians.