Total Ankle Replacement in Hemophilia

Author(s): Emerito C. Rodriguez-Merchan*

Journal Name: Cardiovascular & Hematological Disorders-Drug Targets
(Formerly Current Drug Targets - Cardiovascular & Hematological Disorders)

Volume 20 , Issue 2 , 2020

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Graphical Abstract:


Abstract:

Introduction: Severe ankle hemophilic arthropathy can be a calamitous sign of severe hemophilia with important inferences for activities of daily living.

Aims: To summarize the contemporary, accessible information on Total Ankle Replacement (TAR) for ankle hemophilic arthropathy.

Methods: A search of Cochrane Library and PubMed (MEDLINE) regarding the role of TAR in ankle hemophilic arthropathy.

Results: The insufficient information regarding the results of TAR for hemophilic arthropathy is confined to scanty case series and case reports. An evaluation of the accessible literature reveals encouraging but inconstant outcomes. The reported rate of adverse events is 33%. The reported anticipated survival of TAR is 94% at 5 years, 85% at 10 years and 70% at 15 years.

Conclusion: Whereas people with advanced hemophilic arthropathy of the ankle are prone to ameliorate pain and range of motion following TAR, there is deficient knowledge to regularly recommend its use. Adverse events and infection percentages are disturbing. Moreover, the lack of survival analysis knowledge makes it difficult to assess the benefit to people with hemophilia. TAR is a demanding surgical procedure and its survival is not comparable to that after hip or knee replacement.

Keywords: Hemophilia, hemophilic arthropathy, ankle, total ankle replacement, hemarthrosis, rheumatoid arthritis.

[1]
Rodríguez-Merchán, E.C. The role of orthopaedic surgery in haemophilia: current rationale, indications and results. EFORT Open Rev., 2019, 4(5), 165-173.
[http://dx.doi.org/10.1302/2058-5241.4.180090] [PMID: 31191984]
[2]
Barg, A.; Morris, S.C.; Schneider, S.W.; Phisitkul, P.; Saltzman, C.L. Surgical procedures in patients with haemophilic arthropathy of the ankle. Haemophilia, 2016, 22(3), e156-e176.
[http://dx.doi.org/10.1111/hae.12919] [PMID: 27028454]
[3]
Rodriguez-Merchan, E.C. Ankle surgery in haemophilia with special emphasis on arthroscopic debridement. Haemophilia, 2008, 14(5), 913-919.
[http://dx.doi.org/10.1111/j.1365-2516.2008.01820.x] [PMID: 18637842]
[4]
Rodriguez-Merchan, E.C.; Gomez-Cardero, P.; Martinez-Lloreda, Á.; De La Corte-Rodriguez, H.; Jimenez-Yuste, V. Arthroscopic debridement for ankle haemophilic arthropathy. Blood Coagul. Fibrinol, 2015, 26(3), 279-281.
[http://dx.doi.org/10.1097/MBC.0000000000000230] [PMID: 25402194]
[5]
Rodriguez-Merchan, E.C. Management of hemophilic arthropathy of the ankle. Cardiovasc. Hematol. Disord. Drug Targets, 2017, 17(2), 111-118.
[http://dx.doi.org/10.2174/1871529X17666170908110758] [PMID: 28891453]
[6]
Rodriguez-Merchan, E.C. Total ankle replacement or ankle fusion in painful advanced hemophilic arthropathy of the ankle. Expert Rev. Hematol., 2015, 8(6), 727-731.
[http://dx.doi.org/10.1586/17474086.2015.1087846] [PMID: 26358145]
[7]
Rodriguez-Merchan, E.C. Musculo-skeletal manifestations of haemophilia. Blood Rev., 2016, 30(5), 401-409.
[http://dx.doi.org/10.1016/j.blre.2016.04.008] [PMID: 27166435]
[8]
Luck, J.V., Jr; Silva, M.; Rodriguez-Merchan, E.C.; Ghalambor, N.; Zahiri, C.A.; Finn, R.S. Hemophilic arthropathy. J. Am. Acad. Orthop. Surg., 2004, 12(4), 234-245.
[http://dx.doi.org/10.5435/00124635-200407000-00004] [PMID: 15473675]
[9]
Solimeno, L.P.; Pasta, G. Knee and ankle arthroplasty in hemophilia. J. Clin. Med., 2017, 6(11)E107
[http://dx.doi.org/10.3390/jcm6110107] [PMID: 29165342]
[10]
Henricson, A.; Skoog, A.; Carlsson, A. The Swedish Ankle Arthroplasty Register: An analysis of 531 arthroplasties between 1993 and 2005. Acta Orthop., 2007, 78(5), 569-574.
[http://dx.doi.org/10.1080/17453670710014248] [PMID: 17966014]
[11]
Labek, G.; Todorov, S.; Iovanescu, L.; Stoica, C.I.; Böhler, N. Outcome after total ankle arthroplasty-results and findings from worldwide arthroplasty registers. Int. Orthop., 2013, 37(9), 1677-1682.
[http://dx.doi.org/10.1007/s00264-013-1981-7] [PMID: 23832166]
[12]
Scholz, R.; Scholz, U. [The total ankle replacement for severe arthropathy in haemophilia]. Hamostaseologie, 2008, 28(1), S40-S44.
[http://dx.doi.org/10.1055/s-0037-1617114] [PMID: 18958336]
[13]
van der Heide, H.J.; Nováková, I.; de Waal Malefijt, M.C. The feasibility of total ankle prosthesis for severe arthropathy in haemophilia and prothrombin deficiency. Haemophilia, 2006, 12(6), 679-682.
[http://dx.doi.org/10.1111/j.1365-2516.2006.01350.x] [PMID: 17083522]
[14]
Min, Z.H.; Zhang, H.M. [Study on short-term effects of ankle replacement for the treatment of hemophilic arthritis]. Zhongguo Gu Shang, 2009, 22(6), 428-431.
[PMID: 19594039]
[15]
Berdel, P.; Schott, D.; Pagenstert, G.; Pennekamp, P.; Oldenburg, J.; Wirtz, D.C.; Seuser, A.; Gravius, S. [Upper ankle joint prostheses in haemophilia patients]. Hamostaseologie, 2009, 29(1), S65-S68.
[http://dx.doi.org/10.1055/s-0037-1621497] [PMID: 19763350]
[16]
Barg, A.; Elsner, A.; Hefti, D.; Hintermann, B. Haemophilic arthropathy of the ankle treated by total ankle replacement: a case series. Haemophilia, 2010, 16(4), 647-655.
[http://dx.doi.org/10.1111/j.1365-2516.2010.02221.x] [PMID: 20331757]
[17]
Strauss, A.C.; Goldmann, G.; Wessling, M.; Gravius, S.; Müller, M.C.; Wimmer, M.D.; Wirtz, D.C.; Oldenburg, J.; Pennekamp, P.H. Total ankle replacement in patients with haemophilia and virus infections--a safe alternative to ankle arthrodesis? Haemophilia, 2014, 20(5), 702-708.
[http://dx.doi.org/10.1111/hae.12392] [PMID: 24589152]
[18]
Asencio, J.G.; Leonardi, C.; Biron-Andreani, C.; Schved, J.F. Short-term and mid-term outcome of total ankle replacement in haemophilic patients. Foot Ankle Surg., 2014, 20(4), 285-292.
[http://dx.doi.org/10.1016/j.fas.2014.08.004] [PMID: 25457668]
[19]
Barg, K.; Wiewiorski, M.; Anderson, A.E.; Schneider, S.W.; Wimmer, M.D.; Wirtz, D.C.; Valderrabano, V.; Barg, A.; Pagenstert, G. Total ankle replacement in patients with von Willebrand disease: mid-term results of 18 procedures. Haemophilia, 2015, 21(5), e389-e401.
[http://dx.doi.org/10.1111/hae.12561] [PMID: 25688467]
[20]
Barg, A.; Barg, K.; Wiewiorski, M.; Schneider, S.W.; Wimmer, M.D.; Wirtz, D.C.; Valderrabano, V.; Pagenstert, G. [Total ankle replacement in patients with bleeding disorders]. Orthopade, 2015, 44(8), 623-638.
[http://dx.doi.org/10.1007/s00132-015-3107-y] [PMID: 25944517]
[21]
Yilmaz, B.; Kömür, B.; Özdemir, G.; Heybeli, N. Ankle arthroplasty in a patient with bleeding diathesis and the mid-term clinical outcome of the case. Ann. Med. Surg. (Lond.), 2015, 4(4), 404-406.
[http://dx.doi.org/10.1016/j.amsu.2015.09.003] [PMID: 26635956]
[22]
Dauty, M.; Gross, R.; Leboeuf, F.; Trossaert, M. Comparison of total ankle replacement and ankle arthrodesis in patients with haemophilia using gait analysis: two case reports. BMC Res. Notes, 2015, 8, 768.
[http://dx.doi.org/10.1186/s13104-015-1763-y] [PMID: 26653540]
[23]
Preis, M.; Bailey, T.; Jacxsens, M.; Barg, A. Total ankle replacement in patients with haemophilic arthropathy: primary arthroplasty and conversion of painful ankle arthrodesis to arthroplasty. Haemophilia, 2017, 23(4), e301-e309.
[http://dx.doi.org/10.1111/hae.13200] [PMID: 28306181]
[24]
Eckers, F.; Bauer, D.E.; Hingsammer, A.; Sutter, R.; Brand, B.; Viehöfer, A.; Wirth, S.H. Mid- to long-term results of total ankle replacement in patients with haemophilic arthropathy: A 10-year follow-up. Haemophilia, 2018, 24(2), 307-315.
[http://dx.doi.org/10.1111/hae.13386] [PMID: 29271607]
[25]
Mann, H.A.; Biring, G.S.; Choudhury, M.Z.; Lee, C.A.; Goddard, N.J. Ankle arthropathy in the haemophilic patient: a description of a novel ankle arthrodesis technique. Haemophilia, 2009, 15(2), 458-463.
[http://dx.doi.org/10.1111/j.1365-2516.2008.01651.x] [PMID: 19187197]
[26]
Bluth, B.E.; Fong, Y.J.; Houman, J.J.; Silva, M.; Luck, J.V., Jr Ankle fusion in patients with haemophilia. Haemophilia, 2013, 19(3), 432-437.
[http://dx.doi.org/10.1111/hae.12114] [PMID: 23490189]
[27]
Baker, J.F.; Maleki, F.; Broderick, J.M.; McKenna, J. Arthroscopic ankle arthrodesis for end-stage haemophilic arthropathy of the ankle. Haemophilia, 2014, 20(1), e97-e99.
[http://dx.doi.org/10.1111/hae.12308] [PMID: 24251355]
[28]
Rodriguez-Merchan, E.C.; Moracia-Ochagavia, I. Total ankle arthroplasty: Long-term survival and factors that influence it. Int. J. Orthod., 2019, 6, 1124-1128.


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Article Details

VOLUME: 20
ISSUE: 2
Year: 2020
Page: [88 - 92]
Pages: 5
DOI: 10.2174/1871529X19666191210110626

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