Gene Expression Assay in the Management of Early Breast Cancer

Author(s): Roberta Caputo, Daniela Cianniello*, Antonio Giordano*, Michela Piezzo, Maria Riemma, Marco Trovò, Massimiliano Berretta, Michelino De Laurentiis

Journal Name: Current Medicinal Chemistry

Volume 27 , Issue 17 , 2020


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Abstract:

The addition of adjuvant chemotherapy to hormonal therapy is often considered questionable in patients with estrogen receptor-positive early breast cancer. Low risk of disease relapse after endocrine treatment alone and/or a low sensitivity to chemotherapy are reasons behind not all patients benefit from chemotherapy. Most of the patients could be exposed to unnecessary treatment- related adverse events and health care costs when treatment decision-making is based only on classical clinical histological features. Gene expression profile has been developed to refine physician’s decision-making process and to tailor personalized treatment to patients. In particular, these tests are designed to spare patients the side effects of unnecessary treatment, and ensure that adjuvant chemotherapy is correctly recommended to patients with early breast cancer. In this review, we will discuss the main diagnostic tests and their potential clinical applications (Oncotype DX, MammaPrint, PAM50/Prosigna, EndoPredict, MapQuant Dx, IHC4, and Theros-Breast Cancer Gene Expression Ratio Assay).

Keywords: Adjuvant chemotherapy, early breast cancer (EBC), Oncotype DX, MapQuant Dx, estrogen receptor positive (ER+).

[1]
Coates, A.S.; Winer, E.P.; Goldhirsch, A.; Gelber, R.D.; Gnant, M.; Piccart-Gebhart, M.; Thürlimann, B.; Senn, H.J. Panel members. Tailoring therapies--improving the management of early breast cancer: St. Gallen international expert consensus on the primary therapy of early breast cancer 2015. Ann. Oncol., 2015, 26(8), 1533-1546.
[http://dx.doi.org/10.1093/annonc/mdv221] [PMID: 25939896]
[2]
Loprinzi, C.L.; Ravdin, P.M.; de Laurentiis, M.; Novotny, P. Do American oncologists know how to use prognostic variables for patients with newly diagnosed primary breast cancer? J. Clin. Oncol., 1994, 12(7), 1422-1426.
[http://dx.doi.org/10.1200/JCO.1994.12.7.1422] [PMID: 8021733]
[3]
Marchionni, L.; Wilson, R.F.; Marinopoulos, S.S.; Wolff, A.C.; Parmigiani, G.; Bass, E.B.; Goodman, S.N. Impact of gene expression profiling tests on breast cancer outcomes. Evid. Rep. Technol. Assess. (Full. Rep), 2007, (160), 1-105.
[PMID: 18457476]
[4]
Harris, L.N.; Ismaila, N.; McShane, L.M.; Andre, F.; Collyar, D.E.; Gonzalez-Angulo, A.M.; Hammond, E.H.; Kuderer, N.M.; Liu, M.C.; Mennel, R.G.; Van Poznak, C.; Bast, R.C.; Hayes, D.F. American Society of Clinical Oncology. American society of clinical oncology. use of biomarkers to guide decisions on adjuvant systemic therapy for women with early-stage invasive breast cancer: american society of clinical oncology clinical practice guideline. J. Clin. Oncol., 2016, 34(10), 1134-1150.
[http://dx.doi.org/10.1200/JCO.2015.65.2289] [PMID: 26858339]
[5]
Cronin, M.; Sangli, C.; Liu, M.L.; Pho, M.; Dutta, D.; Nguyen, A.; Jeong, J.; Wu, J.; Langone, K.C.; Watson, D. Analytical validation of the Oncotype DX genomic diagnostic test for recurrence prognosis and therapeutic response prediction in node-negative, estrogen receptor-positive breast cancer. Clin. Chem., 2007, 53(6), 1084-1091.
[http://dx.doi.org/10.1373/clinchem.2006.076497] [PMID: 17463177]
[6]
Paik, S.; Shak, S.; Tang, G.; Kim, C.; Baker, J.; Cronin, M.; Baehner, F.L.; Walker, M.G.; Watson, D.; Park, T.; Hiller, W.; Fisher, E.R.; Wickerham, D.L.; Bryant, J.; Wolmark, N. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N. Engl. J. Med., 2004, 351(27), 2817-2826.
[http://dx.doi.org/10.1056/NEJMoa041588] [PMID: 15591335]
[7]
Paik, S.; Tang, G.; Shak, S.; Kim, C.; Baker, J.; Kim, W.; Cronin, M.; Baehner, F.L.; Watson, D.; Bryant, J.; Costantino, J.P.; Geyer, C.E., Jr; Wickerham, D.L.; Wolmark, N. Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer. J. Clin. Oncol., 2006, 24(23), 3726-3734.
[http://dx.doi.org/10.1200/JCO.2005.04.7985] [PMID: 16720680]
[8]
Habel, L.A.; Shak, S.; Jacobs, M.K.; Capra, A.; Alexander, C.; Pho, M.; Baker, J.; Walker, M.; Watson, D.; Hackett, J.; Blick, N.T.; Greenberg, D.; Fehrenbacher, L.; Langholz, B.; Quesenberry, C.P. A population-based study of tumor gene expression and risk of breast cancer death among lymph node-negative patients. Breast Cancer Res., 2006, 8(3), R25.
[http://dx.doi.org/10.1186/bcr1412] [PMID: 16737553]
[9]
Goldstein, L.J.; Gray, R.; Badve, S.; Childs, B.H.; Yoshizawa, C.; Rowley, S.; Shak, S.; Baehner, F.L.; Ravdin, P.M.; Davidson, N.E.; Sledge, G.W., Jr; Perez, E.A.; Shulman, L.N.; Martino, S.; Sparano, J.A. Prognostic utility of the 21-gene assay in hormone receptor-positive operable breast cancer compared with classical clinicopathologic features. J. Clin. Oncol., 2008, 26(25), 4063-4071.
[http://dx.doi.org/10.1200/JCO.2007.14.4501] [PMID: 18678838]
[10]
Albain, K.S.; Barlow, W.E.; Shak, S.; Hortobagyi, G.N.; Livingston, R.B.; Yeh, I.T.; Ravdin, P.; Bugarini, R.; Baehner, F.L.; Davidson, N.E.; Sledge, G.W.; Winer, E.P.; Hudis, C.; Ingle, J.N.; Perez, E.A.; Pritchard, K.I.; Shepherd, L.; Gralow, J.R.; Yoshizawa, C.; Allred, D.C.; Osborne, C.K.; Hayes, D.F. Breast Cancer Intergroup of North America. Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial. Lancet Oncol., 2010, 11(1), 55-65.
[http://dx.doi.org/10.1016/S1470-2045(09)70314-6] [PMID: 20005174]
[11]
Dowsett, M.; Cuzick, J.; Wale, C.; Forbes, J.; Mallon, E.A.; Salter, J.; Quinn, E.; Dunbier, A.; Baum, M.; Buzdar, A.; Howell, A.; Bugarini, R.; Baehner, F.L.; Shak, S. Prediction of risk of distant recurrence using the 21-gene recurrence score in node-negative and node-positive postmenopausal patients with breast cancer treated with anastrozole or tamoxifen: a TransATAC study. J. Clin. Oncol., 2010, 28(11), 1829-1834.
[http://dx.doi.org/10.1200/JCO.2009.24.4798] [PMID: 20212256]
[12]
Toi, M.; Iwata, H.; Yamanaka, T.; Masuda, N.; Ohno, S.; Nakamura, S.; Nakayama, T.; Kashiwaba, M.; Kamigaki, S.; Kuroi, K. Japan Breast Cancer Research Group-Translational Research Group. Clinical significance of the 21-gene signature (Oncotype DX) in hormone receptor-positive early stage primary breast cancer in the Japanese population. Cancer, 2010, 116(13), 3112-3118.
[http://dx.doi.org/10.1002/cncr.25206] [PMID: 20564629]
[13]
Mamounas, E.P.; Tang, G.; Paik, S.; Baehner, F.L.; Liu, Q.; Jeong, J.H.; Kim, S.R.; Butler, S.M.; Jamshidian, F.; Cherbavaz, D.B.; Sing, A.P.; Shak, S.; Julian, T.B.; Lembersky, B.C.; Wickerham, D.L.; Costantino, J.P.; Wolmark, N. Association between the 21-gene Recurrence Score (RS) and benefit from adjuvant paclitaxel (Pac) in node-positive (Nþ), ER-positive breast cancer patients (pts): results from NSABP B-28. Cancer Res, 2012, 72(Supp. 24), S1-10-S1- 10.
[http://dx.doi.org/10.1158/0008-5472.SABCS12-S1-10]
[14]
Simon, R. Roadmap for developing and validating therapeutically relevant genomic classifiers. J. Clin. Oncol., 2005, 23(29), 7332-7341.
[http://dx.doi.org/10.1200/JCO.2005.02.8712] [PMID: 16145063]
[15]
Simon, R.M.; Paik, S.; Hayes, D.F. Use of archived specimens in evaluation of prognostic and predictive biomarkers. J. Natl. Cancer Inst., 2009, 101(21), 1446-1452.
[http://dx.doi.org/10.1093/jnci/djp335] [PMID: 19815849]
[16]
Sparano, J.A. TAILORx: trial assigning individualized options for treatment (Rx). Clin. Breast Cancer, 2006, 7(4), 347-350.
[http://dx.doi.org/10.3816/CBC.2006.n.051] [PMID: 17092406]
[17]
Sparano, J.A.; Gray, R.J.; Makower, D.F.; Pritchard, K.I.; Albain, K.S.; Hayes, D.F.; Geyer, C.E., Jr; Dees, E.C.; Perez, E.A.; Olson, J.A., Jr; Zujewski, J.; Lively, T.; Badve, S.S.; Saphner, T.J.; Wagner, L.I.; Whelan, T.J.; Ellis, M.J.; Paik, S.; Wood, W.C.; Ravdin, P.; Keane, M.M.; Gomez Moreno, H.L.; Reddy, P.S.; Goggins, T.F.; Mayer, I.A.; Brufsky, A.M.; Toppmeyer, D.L.; Kaklamani, V.G.; Atkins, J.N.; Berenberg, J.L.; Sledge, G.W. Prospective Validation of a 21-Gene Expression Assay in Breast Cancer. N. Engl. J. Med., 2015, 373(21), 2005-2014.
[http://dx.doi.org/10.1056/NEJMoa1510764] [PMID: 26412349]
[18]
Gonzalez-Angulo, A.M.; Barlow, W.E.; Gralow, J.R.; Meric-Bernstam, F.; Hayes, D.F.; Moinpour, C.M.; Ramsey, S.D.; Schott, A.F.; Sparks, D.B.; Albain, K.S.; Hortobagyi, G.N. OT1-03-01: A randomized phase III clinical trial of standard adjuvant en-docrine therapy +/- chemotherapy in patients (pts) with 1-3 positive nodes, hormone receptor (HR)-positive and HER2-negative breast cancer with recurrence score (RS) of 25 or less: SWOG S1007. Cancer Res., 2011, 71(Suppl. 24) OT1-03-01-OT1-03-01.
[http://dx.doi.org/10.1158/0008-5472.SABCS11-OT1-03-01]
[19]
Mook, S.; Schmidt, M.K.; Viale, G.; Pruneri, G.; Eekhout, I.; Floore, A.; Glas, A.M.; Bogaerts, J.; Cardoso, F.; Piccart-Gebhart, M.J.; Rutgers, E.T.; Van’t Veer, L.J. TRANSBIG Consortium. The 70-gene prognosis-signature predicts disease outcome in breast cancer patients with 1-3 positive lymph nodes in an independent validation study. Breast Cancer Res. Treat., 2009, 116(2), 295-302.
[http://dx.doi.org/10.1007/s10549-008-0130-2] [PMID: 18661261]
[20]
Mittempergher, L.; de Ronde, J.J.; Nieuwland, M.; Kerkhoven, R.M.; Simon, I.; Rutgers, E.J.; Wessels, L.F.; Van’t Veer, L.J. Gene expression profiles from formalin fixed paraffin embedded breast cancer tissue are largely comparable to fresh frozen matched tissue. PLoS One, 2011, 6(2) e17163
[http://dx.doi.org/10.1371/journal.pone.0017163] [PMID: 21347257]
[21]
van ’t Veer, L.J.; Dai, H.; van de Vijver, M.J.; He, Y.D.; Hart, A.A.; Mao, M.; Peterse, H.L.; van der Kooy, K.; Marton, M.J.; Witteveen, A.T.; Schreiber, G.J.; Kerkhoven, R.M.; Roberts, C.; Linsley, P.S.; Bernards, R.; Friend, S.H. Gene expression profiling predicts clinical outcome of breast cancer. Nature, 2002, 415(6871), 530-536.
[http://dx.doi.org/10.1038/415530a] [PMID: 11823860]
[22]
van de Vijver, M.J.; He, Y.D.; van’t Veer, L.J.; Dai, H.; Hart, A.A.; Voskuil, D.W.; Schreiber, G.J.; Peterse, J.L.; Roberts, C.; Marton, M.J.; Parrish, M.; Atsma, D.; Witteveen, A.; Glas, A.; Delahaye, L.; van der Velde, T.; Bartelink, H.; Rodenhuis, S.; Rutgers, E.T.; Friend, S.H.; Bernards, R. A gene-expression signature as a predictor of survival in breast cancer. N. Engl. J. Med., 2002, 347(25), 1999-2009.
[http://dx.doi.org/10.1056/NEJMoa021967] [PMID: 12490681]
[23]
Buyse, M.; Loi, S.; van’t Veer, L.; Viale, G.; Delorenzi, M.; Glas, A.M.; d’Assignies, M.S.; Bergh, J.; Lidereau, R.; Ellis, P.; Harris, A.; Bogaerts, J.; Therasse, P.; Floore, A.; Amakrane, M.; Piette, F.; Rutgers, E.; Sotiriou, C.; Cardoso, F.; Piccart, M.J. TRANSBIG Consortium. Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer. J. Natl. Cancer Inst., 2006, 98(17), 1183-1192.
[http://dx.doi.org/10.1093/jnci/djj329] [PMID: 16954471]
[24]
Goldhirsch, A.; Winer, E.P.; Coates, A.S.; Gelber, R.D.; Piccart-Gebhart, M.; Thürlimann, B.; Senn, H.J. Panel members. Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013. Ann. Oncol., 2013, 24(9), 2206-2223.
[http://dx.doi.org/10.1093/annonc/mdt303] [PMID: 23917950]
[25]
Bueno-de-Mesquita, J.M.; Sonke, G.S.; van de Vijver, M.J.; Linn, S.C. Additional value and potential use of the 70-gene prognosis signature in node-negative breast cancer in daily clinical practice. Ann. Oncol., 2011, 22(9), 2021-2030.
[http://dx.doi.org/10.1093/annonc/mdp547] [PMID: 19955335]
[26]
Wittner, B.S.; Sgroi, D.C.; Ryan, P.D.; Bruinsma, T.J.; Glas, A.M.; Male, A.; Dahiya, S.; Habin, K.; Bernards, R.; Haber, D.A.; Van’t Veer, L.J.; Ramaswamy, S. Analysis of the MammaPrint breast cancer assay in a predominantly postmenopausal cohort. Clin. Cancer Res., 2008, 14(10), 2988-2993.
[http://dx.doi.org/10.1158/1078-0432.CCR-07-4723] [PMID: 18483364]
[27]
Mook, S.; Schmidt, M.K.; Weigelt, B.; Kreike, B.; Eekhout, I.; van de Vijver, M.J.; Glas, A.M.; Floore, A.; Rutgers, E.J.; van ’t Veer, L.J. The 70-gene prognosis signature predicts early metastasis in breast cancer patients between 55 and 70 years of age. Ann. Oncol., 2010, 21(4), 717-722.
[http://dx.doi.org/10.1093/annonc/mdp388] [PMID: 19825882]
[28]
Drukker, C.A.; Bueno-de-Mesquita, J.M.; Retèl, V.P.; van Harten, W.H.; van Tinteren, H.; Wesseling, J.; Roumen, R.M.; Knauer, M.; van ’t Veer, L.J.; Sonke, G.S.; Rutgers, E.J.; van de Vijver, M.J.; Linn, S.C. A prospective evaluation of a breast cancer prognosis signature in the observational RASTER study. Int. J. Cancer, 2013, 133(4), 929-936.
[http://dx.doi.org/10.1002/ijc.28082] [PMID: 23371464]
[29]
Cardoso, F.; van’t Veer, L.J.; Bogaerts, J.; Slaets, L.; Viale, G.; Delaloge, S.; Pierga, J.Y.; Brain, E.; Causeret, S.; DeLorenzi, M.; Glas, A.M.; Golfinopoulos, V.; Goulioti, T.; Knox, S.; Matos, E.; Meulemans, B.; Neijenhuis, P.A.; Nitz, U.; Passalacqua, R.; Ravdin, P.; Rubio, I.T.; Saghatchian, M.; Smilde, T.J.; Sotiriou, C.; Stork, L.; Straehle, C.; Thomas, G.; Thompson, A.M.; van der Hoeven, J.M.; Vuylsteke, P.; Bernards, R.; Tryfonidis, K.; Rutgers, E.; Piccart, M. MINDACT Investigators. 70-Gene signature as an aid to treatment decisions in early-stage breast cancer. N. Engl. J. Med., 2016, 375(8), 717-729.
[http://dx.doi.org/10.1056/NEJMoa1602253] [PMID: 27557300]
[30]
Perou, C.M.; Sørlie, T.; Eisen, M.B.; van de Rijn, M.; Jeffrey, S.S.; Rees, C.A.; Pollack, J.R.; Ross, D.T.; Johnsen, H.; Akslen, L.A.; Fluge, O.; Pergamenschikov, A.; Williams, C.; Zhu, S.X.; Lønning, P.E.; Børresen-Dale, A.L.; Brown, P.O.; Botstein, D. Molecular portraits of human breast tumours. Nature, 2000, 406(6797), 747-752.
[http://dx.doi.org/10.1038/35021093] [PMID: 10963602]
[31]
Sørlie, T.; Perou, C.M.; Tibshirani, R.; Aas, T.; Geisler, S.; Johnsen, H.; Hastie, T.; Eisen, M.B.; van de Rijn, M.; Jeffrey, S.S.; Thorsen, T.; Quist, H.; Matese, J.C.; Brown, P.O.; Botstein, D.; Lønning, P.E.; Børresen-Dale, A.L. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl. Acad. Sci. USA, 2001, 98(19), 10869-10874.
[http://dx.doi.org/10.1073/pnas.191367098] [PMID: 11553815]
[32]
Parker, J.S.; Mullins, M.; Cheang, M.C.; Leung, S.; Voduc, D.; Vickery, T.; Davies, S.; Fauron, C.; He, X.; Hu, Z.; Quackenbush, J.F.; Stijleman, I.J.; Palazzo, J.; Marron, J.S.; Nobel, A.B.; Mardis, E.; Nielsen, T.O.; Ellis, M.J.; Perou, C.M.; Bernard, P.S. Supervised risk predictor of breast cancer based on intrinsic subtypes. J. Clin. Oncol., 2009, 27(8), 1160-1167.
[http://dx.doi.org/10.1200/JCO.2008.18.1370] [PMID: 19204204]
[33]
Reis, P.P.; Waldron, L.; Goswami, R.S.; Xu, W.; Xuan, Y.; Perez-Ordonez, B.; Gullane, P.; Irish, J.; Jurisica, I.; Kamel-Reid, S. mRNA transcript quantification in archival samples using multiplexed, color-coded probes. BMC Biotechnol., 2011, 11, 46.
[http://dx.doi.org/10.1186/1472-6750-11-46] [PMID: 21549012]
[34]
Nielsen, T.O.; Parker, J.S.; Leung, S.; Voduc, D.; Ebbert, M.; Vickery, T.; Davies, S.R.; Snider, J.; Stijleman, I.J.; Reed, J.; Cheang, M.C.; Mardis, E.R.; Perou, C.M.; Bernard, P.S.; Ellis, M.J. A comparison of PAM50 intrinsic subtyping with immunohistochemistry and clinical prognostic factors in tamoxifen-treated estrogen receptor-positive breast cancer. Clin. Cancer Res., 2010, 16(21), 5222-5232.
[http://dx.doi.org/10.1158/1078-0432.CCR-10-1282] [PMID: 20837693]
[35]
Wallden, B.; Storhoff, J.; Nielsen, T.; Dowidar, N.; Schaper, C.; Ferree, S.; Liu, S.; Leung, S.; Geiss, G.; Snider, J.; Vickery, T.; Davies, S.R.; Mardis, E.R.; Gnant, M.; Sestak, I.; Ellis, M.J.; Perou, C.M.; Bernard, P.S.; Parker, J.S. Development and verification of the PAM50-based Prosigna breast cancer gene signature assay. BMC Med. Genomics, 2015, 8, 54.
[http://dx.doi.org/10.1186/s12920-015-0129-6] [PMID: 26297356]
[36]
Gnant, M.; Filipits, M.; Greil, R.; Stoeger, H.; Rudas, M.; Bago-Horvath, Z.; Mlineritsch, B.; Kwasny, W.; Knauer, M.; Singer, C.; Jakesz, R.; Dubsky, P.; Fitzal, F.; Bartsch, R.; Steger, G.; Balic, M.; Ressler, S.; Cowens, J.W.; Storhoff, J.; Ferree, S.; Schaper, C.; Liu, S.; Fesl, C.; Nielsen, T.O. Austrian Breast and Colorectal Cancer Study Group. Predicting distant recurrence in receptor-positive breast cancer patients with limited clinicopathological risk: using the PAM50 Risk of Recurrence score in 1478 postmenopausal patients of the ABCSG-8 trial treated with adjuvant endocrine therapy alone. Ann. Oncol., 2014, 25(2), 339-345.
[http://dx.doi.org/10.1093/annonc/mdt494] [PMID: 24347518]
[37]
Chia, S.K.; Bramwell, V.H.; Tu, D.; Shepherd, L.E.; Jiang, S.; Vickery, T.; Mardis, E.; Leung, S.; Ung, K.; Pritchard, K.I.; Parker, J.S.; Bernard, P.S.; Perou, C.M.; Ellis, M.J.; Nielsen, T.O. A 50-gene intrinsic subtype classifier for prognosis and prediction of benefit from adjuvant tamoxifen. Clin. Cancer Res., 2012, 18(16), 4465-4472.
[http://dx.doi.org/10.1158/1078-0432.CCR-12-0286] [PMID: 22711706]
[38]
Prat, A.; Bianchini, G.; Thomas, M.; Belousov, A.; Cheang, M.C.; Koehler, A.; Gómez, P.; Semiglazov, V.; Eiermann, W.; Tjulandin, S.; Byakhow, M.; Bermejo, B.; Zambetti, M.; Vazquez, F.; Gianni, L.; Baselga, J. Research-based PAM50 subtype predictor identifies higher responses and improved survival outcomes in HER2-positive breast cancer in the NOAH study. Clin. Cancer Res., 2014, 20(2), 511-521.
[http://dx.doi.org/10.1158/1078-0432.CCR-13-0239] [PMID: 24443618]
[39]
Martin, M.; Romero, A.; Cheang, M.C.; López García-Asenjo, J.A.; García-Saenz, J.A.; Oliva, B.; Román, J.M.; He, X.; Casado, A.; de la Torre, J.; Furio, V.; Puente, J.; Caldés, T.; Vidart, J.A.; Lopez-Tarruella, S.; Diaz-Rubio, E.; Perou, C.M. Genomic predictors of response to doxorubicin versus docetaxel in primary breast cancer. Breast Cancer Res. Treat., 2011, 128(1), 127-136.
[http://dx.doi.org/10.1007/s10549-011-1461-y] [PMID: 21465170]
[40]
Harvell, D.M.; Spoelstra, N.S.; Singh, M.; McManaman, J.L.; Finlayson, C.; Phang, T.; Trapp, S.; Hunter, L.; Dye, W.W.; Borges, V.F.; Elias, A.; Horwitz, K.B.; Richer, J.K. Molecular signatures of neoadjuvant endocrine therapy for breast cancer: characteristics of response or intrinsic resistance. Breast Cancer Res. Treat., 2008, 112(3), 475-488.
[http://dx.doi.org/10.1007/s10549-008-9897-4] [PMID: 18327671]
[41]
Cheang, M.C.; Voduc, K.D.; Tu, D.; Jiang, S.; Leung, S.; Chia, S.K.; Shepherd, L.E.; Levine, M.N.; Pritchard, K.I.; Davies, S.; Stijleman, I.J.; Davis, C.; Ebbert, M.T.; Parker, J.S.; Ellis, M.J.; Bernard, P.S.; Perou, C.M.; Nielsen, T.O. Responsiveness of intrinsic subtypes to adjuvant anthracycline substitution in the NCIC.CTG MA.5 randomized trial. Clin. Cancer Res., 2012, 18, 2402-2412.
[http://dx.doi.org/10.1158/1078-0432.CCR-11-2956] [PMID: 22351696]
[42]
Esserman, L.J.; Berry, D.A.; Cheang, M.C.; Yau, C.; Perou, C.M.; Carey, L.; DeMichele, A.; Gray, J.W.; Conway-Dorsey, K.; Lenburg, M.E.; Buxton, M.B.; Davis, S.E.; van’t Veer, L.J.; Hudis, C.; Chin, K.; Wolf, D.; Krontiras, H.; Montgomery, L.; Tripathy, D.; Lehman, C.; Liu, M.C.; Olopade, O.I.; Rugo, H.S.; Carpenter, J.T.; Livasy, C.; Dressler, L.; Chhieng, D.; Singh, B.; Mies, C.; Rabban, J.; Chen, Y.Y.; Giri, D.; Au, A.; Hylton, N. I-SPY 1 TRIAL Investigators. Chemotherapy response and recurrence-free survival in neoadjuvant breast cancer depends on biomarker profiles: results from the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657). Breast Cancer Res. Treat., 2012, 132(3), 1049-1062.
[http://dx.doi.org/10.1007/s10549-011-1895-2] [PMID: 22198468]
[43]
Martín, M.; Prat, A.; Rodríguez-Lescure, A.; Caballero, R.; Ebbert, M.T.; Munárriz, B.; Ruiz-Borrego, M.; Bastien, R.R.; Crespo, C.; Davis, C.; Rodríguez, C.A.; López-Vega, J.M.; Furió, V.; García, A.M.; Casas, M.; Ellis, M.J.; Berry, D.A.; Pitcher, B.N.; Harris, L.; Ruiz, A.; Winer, E.; Hudis, C.; Stijleman, I.J.; Tuck, D.P.; Carrasco, E.; Perou, C.M.; Bernard, P.S. PAM50 proliferation score as a predictor of weekly paclitaxel benefit in breast cancer. Breast Cancer Res. Treat., 2013, 138(2), 457-466.
[http://dx.doi.org/10.1007/s10549-013-2416-2] [PMID: 23423445]
[44]
Liu, M.C.; Pitcher, B.N.; Mardis, E.R.; Davies, S.R.; Friedman, P.N.; Snider, J.E.; Vickery, T.L.; Reed, J.P.; DeSchryver, K.; Singh, B.; Gradishar, W.J.; Perez, E.A.; Martino, S.; Citron, M.L.; Norton, L.; Winer, E.P.; Hudis, C.A.; Carey, L.A.; Bernard, P.S.; Nielsen, T.O.; Perou, C.M.; Ellis, M.J.; Barry, W.T. PAM50 gene signatures and breast cancer prognosis with adjuvant anthracycline- and taxane-based chemotherapy: correlative analysis of C9741 (Alliance). NPJ Breast Cancer, 2016, 2, 15023.
[http://dx.doi.org/10.1038/npjbcancer.2015.23] [PMID: 28691057]
[45]
Dowsett, M.; Sestak, I.; Lopez-Knowles, E.; Sidhu, K.; Dunbier, A.K.; Cowens, J.W.; Ferree, S.; Storhoff, J.; Schaper, C.; Cuzick, J. Comparison of PAM50 risk of recurrence score with oncotype DX and IHC4 for predicting risk of distant recurrence after endocrine therapy. J. Clin. Oncol., 2013, 31(22), 2783-2790.
[http://dx.doi.org/10.1200/JCO.2012.46.1558] [PMID: 23816962]
[46]
Sestak, I.; Dowsett, M.; Zabaglo, L.; Lopez-Knowles, E.; Ferree, S.; Cowens, J.W.; Cuzick, J. Factors predicting late recurrence for estrogen receptor-positive breast cancer. J. Natl. Cancer Inst., 2013, 105(19), 1504-1511.
[http://dx.doi.org/10.1093/jnci/djt244] [PMID: 24029245]
[47]
Gnant, M.; Filipits, M.; Mlineritsch, B.; Dubsky, P.; Jakesz, R.; Kwasny, W.; Fitzal, F.; Rudas, M.; Knauer, M.; Singer, C.; Greil, R.; Ferree, S.; Storhoff, J.; Cowens, J.W.; Schaper, C.; Liu, S.; Nielsen, T. Clinical validation of the PAM50 risk of recurrence (ROR) score for predicting residual risk of distant-recurrence (DR) after endocrine therapy in postmenopausal women with ER + early breast cancer (EBC): An ABCSG study. Cancer Res., 2012, 72(Suppl. 24) P2-10-02.
[http://dx.doi.org/10.1158/1078-0432.CCR-13-1845] [PMID: 24520097]
[48]
Gnant, M.; Filipits, M.; Dubsky, P.; Rudas, M.; Balic, M.; Greil, R.; Ferree, S.; Cowens, J.W.; Schaper, C.; Nielsen, T. Predicting risk for late metastasis: The PAM50 risk of recurrence (ROR) score after 5 years of endocrine therapy in postmenopausal women with HR + early breast cancer: A study on 1,478 patients from the ABCSG-8 trial. Ann. Oncol., 2013, 24(3), 29.
[http://dx.doi.org/10.1093/annonc/mdt084.1]
[49]
Gnant, M.; Sestak, I.; Filipits, M.; Dowsett, M.; Balic, M.; Lopez-Knowles, E.; Greil, R.; Dubsky, P.; Stoeger, H.; Rudas, M.; Jakesz, R.; Ferree, S.; Cowens, J.W.; Nielsen, T.; Schaper, C.; Fesl, C.; Cuzick, J. Identifying clinically relevant prognostic subgroups of postmenopausal women with node-positive hormone receptor-positive early-stage breast cancer treated with endocrine therapy: a combined analysis of ABCSG-8 and ATAC using the PAM50 risk of recurrence score and intrinsic subtype. Ann. Oncol., 2015, 26(8), 1685-1691.
[http://dx.doi.org/10.1093/annonc/mdv215] [PMID: 25935792]
[50]
Sestak, I.; Cuzick, J.; Dowsett, M.; Lopez-Knowles, E.; Filipits, M.; Dubsky, P.; Cowens, J.W.; Ferree, S.; Schaper, C.; Fesl, C.; Gnant, M. Prediction of late distant recurrence after 5 years of endocrine treatment: a combined analysis of patients from the Austrian breast and colorectal cancer study group 8 and arimidex, tamoxifen alone or in combination randomized trials using the PAM50 risk of recurrence score. J. Natl. Cancer Inst., 2013, 105, 1504-1511.
[http://dx.doi.org/10.1093/jnci/djt244] [PMID: 24029245]
[51]
Prat, A.; Parker, J.S.; Fan, C.; Cheang, M.C.; Miller, L.D.; Bergh, J.; Chia, S.K.; Bernard, P.S.; Nielsen, T.O.; Ellis, M.J.; Carey, L.A.; Perou, C.M. Concordance among gene expression-based predictors for ER-positive breast cancer treated with adjuvant tamoxifen. Ann. Oncol., 2012, 23(11), 2866-2873.
[http://dx.doi.org/10.1093/annonc/mds080] [PMID: 22532584]
[52]
Filipits, M.; Rudas, M.; Jakesz, R.; Dubsky, P.; Fitzal, F.; Singer, C.F.; Dietze, O.; Greil, R.; Jelen, A.; Sevelda, P.; Freibauer, C.; Müller, V.; Jänicke, F.; Schmidt, M.; Kölbl, H.; Rody, A.; Kaufmann, M.; Schroth, W.; Brauch, H.; Schwab, M.; Fritz, P.; Weber, K.E.; Feder, I.S.; Hennig, G.; Kronenwett, R.; Gehrmann, M.; Gnant, M.; Investigators, E.P.E.P. EP Investigators. A new molecular predictor of distant recurrence in ER-positive, HER2-negative breast cancer adds independent information to conventional clinical risk factors. Clin. Cancer Res., 2011, 17(18), 6012-6020.
[http://dx.doi.org/10.1158/1078-0432.CCR-11-0926] [PMID: 21807638]
[53]
Dubsky, P.; Brase, J.C.; Jakesz, R.; Rudas, M.; Singer, C.F.; Greil, R.; Dietze, O.; Luisser, I.; Klug, E.; Sedivy, R.; Bachner, M.; Mayr, D.; Schmidt, M.; Gehrmann, M.C.; Petry, C.; Weber, K.E.; Fisch, K.; Kronenwett, R.; Gnant, M.; Filipits, M. Austrian Breast and Colorectal Cancer Study Group (ABCSG). The EndoPredict score provides prognostic information on late distant metastases in ER+/HER2- breast cancer patients. Br. J. Cancer, 2013, 109(12), 2959-2964.
[http://dx.doi.org/10.1038/bjc.2013.671] [PMID: 24157828]
[54]
Martin, M.; Brase, J.C.; Calvo, L.; Krappmann, K.; Ruiz-Borrego, M.; Fisch, K.; Ruiz, A.; Weber, K.E.; Munarriz, B.; Petry, C.; Rodriguez, C.A.; Kronenwett, R.; Crespo, C.; Alba, E.; Carrasco, E.; Casas, M.; Caballero, R.; Rodriguez-Lescure, A. Clinical validation of the EndoPredict test in node-positive, chemotherapy-treated ER+/HER2- breast cancer patients: results from the GEICAM 9906 trial. Breast Cancer Res., 2014, 16(2), R38.
[http://dx.doi.org/10.1186/bcr3642] [PMID: 24725534]
[55]
Buus, R.; Sestak, I.; Kronenwett, R.; Denkert, C.; Dubsky, P.; Krappmann, K.; Scheer, M.; Petry, C.; Cuzick, J.; Dowsett, M. Comparison of EndoPredict and EPclin with oncotype DX recurrence score for prediction of risk of distant recurrence after endocrine therapy. J. Natl. Cancer Inst., 2016, 108(11) djw149
[http://dx.doi.org/10.1093/jnci/djw149] [PMID: 27400969]
[56]
Sotiriou, C.; Wirapati, P.; Loi, S.; Harris, A.; Fox, S.; Smeds, J.; Nordgren, H.; Farmer, P.; Praz, V.; Haibe-Kains, B.; Desmedt, C.; Larsimont, D.; Cardoso, F.; Peterse, H.; Nuyten, D.; Buyse, M.; Van de Vijver, M.J.; Bergh, J.; Piccart, M.; Delorenzi, M. Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis. J. Natl. Cancer Inst., 2006, 98(4), 262-272.
[http://dx.doi.org/10.1093/jnci/djj052] [PMID: 16478745]
[57]
Metzger Filho, O.; Ignatiadis, M.; Sotiriou, C. Genomic Grade Index: An important tool for assessing breast cancer tumor grade and prognosis. Crit. Rev. Oncol. Hematol., 2011, 77(1), 20-29.
[http://dx.doi.org/10.1016/j.critrevonc.2010.01.011] [PMID: 20138540]
[58]
Goldhirsch, A.; Ingle, J.N.; Gelber, R.D.; Coates, A.S.; Thürlimann, B.; Senn, H.J. Panel members. Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009. Ann. Oncol., 2009, 20(8), 1319-1329.
[http://dx.doi.org/10.1093/annonc/mdp322] [PMID: 19535820]
[59]
Liedtke, C.; Hatzis, C.; Symmans, W.F.; Desmedt, C.; Haibe-Kains, B.; Valero, V.; Kuerer, H.; Hortobagyi, G.N.; Piccart-Gebhart, M.; Sotiriou, C.; Pusztai, L. Genomic grade index is associated with response to chemotherapy in patients with breast cancer. J. Clin. Oncol., 2009, 27(19), 3185-3191.
[http://dx.doi.org/10.1200/JCO.2008.18.5934] [PMID: 19364972]
[60]
Ignatiadis, M.; Singhal, S.K.; Desmedt, C.; Haibe-Kains, B.; Criscitiello, C.; Andre, F.; Loi, S.; Piccart, M.; Michiels, S.; Sotiriou, C. Gene modules and response to neoadjuvant chemotherapy in breast cancer subtypes: a pooled analysis. J. Clin. Oncol., 2012, 30(16), 1996-2004.
[http://dx.doi.org/10.1200/JCO.2011.39.5624] [PMID: 22508827]
[61]
Laios, I.; Carpentier, S.; Veys, I.; Spinette, S.; Salgado, R.; Craciun, L.; Fasolo, V.; Volpe, A.; Girardi, H.; Catteau, A.; Peyro-Saint-Paul, H.; Piccart, M.; Sotiriou, C.; Larsimont, D. PCR genomic grade in breast cancer: a new tool for daily practice. Cancer Res., 2011, 71(Suppl. 24) P1-07-08-P1-07- 08.
[http://dx.doi.org/10.1158/0008-5472.SABCS11-P1-07-08]
[62]
Thürlimann, B.; Keshaviah, A.; Coates, A.S.; Mouridsen, H.; Mauriac, L.; Forbes, J.F.; Paridaens, R.; Castiglione-Gertsch, M.; Gelber, R.D.; Rabaglio, M.; Smith, I.; Wardley, A.; Price, K.N.; Goldhirsch, A. Breast International Group (BIG) 1-98 Collaborative Group. A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer. N. Engl. J. Med., 2005, 353(26), 2747-2757.
[http://dx.doi.org/10.1056/NEJMoa052258] [PMID: 16382061]
[63]
Regan, M.M.; Neven, P.; Giobbie-Hurder, A.; Goldhirsch, A.; Ejlertsen, B.; Mauriac, L.; Forbes, J.F.; Smith, I.; Láng, I.; Wardley, A.; Rabaglio, M.; Price, K.N.; Gelber, R.D.; Coates, A.S.; Thürlimann, B. BIG 1-98 Collaborative Group. International Breast Cancer Study Group (IBCSG). Assessment of letrozole and tamoxifen alone and in sequence for postmenopausal women with steroid hormone receptor-positive breast cancer: the BIG 1-98 randomised clinical trial at 8·1 years median follow-up. Lancet Oncol., 2011, 12(12), 1101-1108.
[http://dx.doi.org/10.1016/S1470-2045(11)70270-4] [PMID: 22018631]
[64]
Ignatiadis, M.; Azim, H.A., Jr; Desmedt, C.; Veys, I.; Larsimont, D.; Salgado, R.; Lyng, M.B.; Viale, G.; Leyland-Jones, B.; Giobbie-Hurder, A.; Kammler, R.; Dell’Orto, P.; Rothé, F.; Laïos, I.; Ditzel, H.J.; Regan, M.M.; Piccart, M.; Michiels, S.; Sotiriou, C. The genomic grade assay compared with Ki67 to determine risk of distant breast cancer recurrence. JAMA Oncol., 2016, 2(2), 217-224.
[http://dx.doi.org/10.1001/jamaoncol.2015.4377] [PMID: 26633571]
[65]
Jerevall, P.L.; Ma, X.J.; Li, H.; Salunga, R.; Kesty, N.C.; Erlander, M.G.; Sgroi, D.C.; Holmlund, B.; Skoog, L.; Fornander, T.; Nordenskjöld, B.; Stål, O. Prognostic utility of HOXB13:IL17BR and molecular grade index in early-stage breast cancer patients from the Stockholm trial. Br. J. Cancer, 2011, 104(11), 1762-1769.
[http://dx.doi.org/10.1038/bjc.2011.145] [PMID: 21559019]
[66]
Ma, X.J.; Salunga, R.; Dahiya, S.; Wang, W.; Carney, E.; Durbecq, V.; Harris, A.; Goss, P.; Sotiriou, C.; Erlander, M.; Sgroi, D. A five-gene molecular grade index and HOXB13:IL17BR are complementary prognostic factors in early stage breast cancer. Clin. Cancer Res., 2008, 14(9), 2601-2608.
[http://dx.doi.org/10.1158/1078-0432.CCR-07-5026] [PMID: 18451222]
[67]
Jankowitz, R.C.; Cooper, K.; Erlander, M.G.; Ma, X.J.; Kesty, N.C.; Li, H.; Chivukula, M.; Brufsky, A. Prognostic utility of the breast cancer index and comparison to Adjuvant! Online in a clinical case series of early breast cancer. Breast Cancer Res., 2011, 13(5), R98.
[http://dx.doi.org/10.1186/bcr3038] [PMID: 21999244]
[68]
Ma, X.J.; Hilsenbeck, S.G.; Wang, W.; Ding, L.; Sgroi, D.C.; Bender, R.A.; Osborne, C.K.; Allred, D.C.; Erlander, M.G. The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer. J. Clin. Oncol., 2006, 24(28), 4611-4619.
[http://dx.doi.org/10.1200/JCO.2006.06.6944] [PMID: 17008703]
[69]
Goetz, M.P.; Suman, V.J.; Ingle, J.N.; Nibbe, A.M.; Visscher, D.W.; Reynolds, C.A.; Lingle, W.L.; Erlander, M.; Ma, X.J.; Sgroi, D.C.; Perez, E.A.; Couch, F.J. A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen. Clin. Cancer Res., 2006, 12(7 Pt 1), 2080-2087.
[http://dx.doi.org/10.1158/1078-0432.CCR-05-1263] [PMID: 16609019]
[70]
Jerevall, P.L.; Brommesson, S.; Strand, C.; Gruvberger-Saal, S.; Malmström, P.; Nordenskjöld, B.; Wingren, S.; Söderkvist, P.; Fernö, M.; Stål, O. Exploring the two-gene ratio in breast cancer--independent roles for HOXB13 and IL17BR in prediction of clinical outcome. Breast Cancer Res. Treat., 2008, 107(2), 225-234.
[http://dx.doi.org/10.1007/s10549-007-9541-8] [PMID: 17453342]
[71]
Jerevall, P.L.; Jansson, A.; Fornander, T.; Skoog, L.; Nordenskjöld, B.; Stål, O. Predictive relevance of HOXB13 protein expression for tamoxifen benefit in breast cancer. Breast Cancer Res., 2010, 12(4), R53.
[http://dx.doi.org/10.1186/bcr2612] [PMID: 20649975]


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VOLUME: 27
ISSUE: 17
Year: 2020
Published on: 04 June, 2020
Page: [2826 - 2839]
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DOI: 10.2174/0929867326666191205163329
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