Title:Imidazole: An Emerging Scaffold Showing its Therapeutic Voyage to Develop Valuable Molecular Entities
VOLUME: 12 ISSUE: 2
Author(s):Bhawna Chopra*, Ashwani K. Dhingra and Deo Nandan Prasad
Affiliation:Department of Pharmaceutical Science, Guru Gobind Singh College of Pharmacy, Yamuna Nagar-135001, Haryana, Department of Pharmaceutical Science, Guru Gobind Singh College of Pharmacy, Yamuna Nagar-135001, Haryana, Shivalik College of Pharmacy, Nangal-140124, Punjab
Keywords:Imidazole, imidazolones, biological activity, microwave, discovery, heterocyclic.
Abstract:
Objective: Imidazole is a heterocyclic moiety having immense biological importance.
Since ancient times, the imidazole nucleus is considered to be a promising moiety in the field of
chemistry. Preliminary in vitro and in vivo studies have provided valuable scientific evidence for its
use. Subsequently, imidazole constitutes a new class of compounds for new drug development as the
presence of this nucleus in diverse therapeutic categories viz; antimicrobial, anti-inflammatory, anticancer,
immunomodulator, antiviral etc. has made it an interesting moiety for the design and development
of new pharmacological agents. Thus, this review aims to summarize the reported molecular
entities which were synthesized by using conventional as well as microwave processes, chemistry
and biological potential of imidazole containing heterocyclic molecules while identifying potential
areas of further research on imidazole.
Results: The review comprises literature pertaining to the evidence-based pharmacological or therapeutic
potential of imidazole using published articles and worldwide databases. Various pharmacological
experiments using different models exclusively proved the potential of imidazole.
Summary: Focusing on the discovery and development of new imidazole nucleus based molecules
at a faster rate, there is a need to search previous information available in the market in the field of
medicinal chemistry. Therefore, the present review aims to elaborate the therapeutic worth of imidazole
and its analogs.
