Alzheimer’s Disease: A Contextual Link with Nitric Oxide Synthase

Author(s): Harikesh Dubey, Kavita Gulati, Arunabha Ray*

Journal Name: Current Molecular Medicine

Volume 20 , Issue 7 , 2020

  Journal Home
Translate in Chinese
Become EABM
Become Reviewer
Call for Editor


Nitric oxide (NO) is a gasotransmitter with pleiotropic effects which has made a great impact on biology and medicine. A multidimensional neuromodulatory role of NO has been shown in the brain with specific reference to neurodegenerative disorders like Alzheimer’s disease (AD) and cognitive dysfunction. It has been found that NO/cGMP signalling pathway has an important role in learning and memory. Initially, it was considered that indirectly NO exerted neurotoxicity in AD via glutamatergic excitotoxicity. However, considering the early development of cognitive functions involved in the learning memory process including long term potentiation and synaptic plasticity, NO has a crucial role. Increasing evidence uncovered the above facts that isoforms of NOS viz endothelial NO synthase (eNOS), neuronal NO synthase (nNOS) and inducible NO synthase (iNOS) having a variable expression in AD are mainly responsible for learning and memory activities. In this review, we focus on the role of NOS isoforms in AD parallel to NO. Further, this review provides convergent evidence that NO could provide a therapeutic avenue in AD via modulation of the relevant NOS expression.

Keywords: Alzheimer's disease, nitric oxide, cGMP, excitotoxicity, NOS, gasotransmitter.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2020
Published on: 24 July, 2020
Page: [505 - 515]
Pages: 11
DOI: 10.2174/1566524019666191129103117
Price: $65

Article Metrics

PDF: 27