The Association Between Keratoconus and Mitral Valve Prolapse: A Meta-Analysis

Author(s): Juan A. Siordia*, Jimena C. Franco.

Journal Name: Current Cardiology Reviews

Volume 16 , Issue 2 , 2020

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

Objective: The debate pertaining to the association between Keratoconus (KC) and Mitral Valve Prolapse (MVP) continues to occur among physicians. The results of cross-sectional studies attempting to present the co-existing prevalence of these two diseases remain indeterminate. We compiled the first meta-analysis to determine the pattern of prevalence between the two diseases.

Methods: Two separate literature searches for cross-sectional studies were performed for this metaanalysis. The first search encompassed finding literature comparing the prevalence of KC between patients with MVP and a control group. The second search pertained to finding studies comparing the prevalence of MVP patients with KC and a control group.

Results: Six studies reported the prevalence of MVP in patients with KC and a control group. The prevalence was 41.6% in patients with KC and 11.5% in patients without KC (OR = 7.06 [95% CI = 2.41-20.64]). There was a significant heterogeneity among the studies (I2 = 84%). Two studies showed the prevalence of KC in patients with MVP and a control group. The prevalence was 17.0% in patients with KC and 2.9% in the control group (OR = 5.07 [95% CI = 1.08-23.83]). There was no heterogeneity within the analysis (I2 = 0%).

Conclusion: There is a statistically significant co-existing prevalence between MVP and KC. Patients with KC are more likely to present with MVP, and patients with MVP are more likely to present with KC.

Keywords: Keratoconus, mitral valve prolapse, association, epidemiology, cardiology, ophthalmology.

[1]
Beardsley TL, Foulks GN. An association of keratoconus and mitral valve prolapse. Ophthalmology 1982; 89(1): 35-7.
[http://dx.doi.org/10.1016/S0161-6420(82)34857-5] [PMID: 7070771]
[2]
Kalkan Akcay E, Akcay M, Uysal BS, et al. Impaired corneal biomechanical properties and the prevalence of keratoconus in mitral valve prolapse. J Ophthalmol 2014; 2014402193
[http://dx.doi.org/10.1155/2014/402193] [PMID: 24864193]
[3]
Rabbanikhah Z, Javadi MA, Rostami P, et al. Association between acute corneal hydrops in patients with keratoconus and mitral valve prolapse. Cornea 2011; 30(2): 154-7.
[http://dx.doi.org/10.1097/ICO.0b013e3181e846a2] [PMID: 21045676]
[4]
Sharif KW, Casey TA, Coltart J. Prevalence of mitral valve prolapse in keratoconus patients. J R Soc Med 1992; 85(8): 446-8.
[PMID: 1404188]
[5]
Street DA, Vinokur ET, Waring GO III, Pollak SJ, Clements SD, Perkins JV. Lack of association between keratoconus, mitral valve prolapse, and joint hypermobility. Ophthalmology 1991; 98(2): 170-6.
[http://dx.doi.org/10.1016/S0161-6420(91)32320-0] [PMID: 2008274]
[6]
Javadi MA, Seadat H, Jafarinasab MR, et al. Association of keratoconus and mitral valve prolapse. Iran J Ophthalmic Res 2007; 2(1): 15-8.
[7]
Mohammady M, Solaimani MR, Movahedan H. Keratoconus and congenital degenerative heart diseases. J Rafsanjan Univ Med Sci Health Serv 2001; 1: 37-41.
[8]
Devereux RB, Perloff JK, Reichek N, Josephson ME. Mitral valve prolapse. Circulation 1976; 54(1): 3-14.
[http://dx.doi.org/10.1161/01.CIR.54.1.3] [PMID: 776440]
[9]
Siordia JA. Current discoveries and interventions for Barlow’s Disease. Curr Cardiol Rep 2016; 18(8): 73.
[http://dx.doi.org/10.1007/s11886-016-0754-5] [PMID: 27312933]
[10]
Cannon DJ, Foster CS. Collagen crosslinking in keratoconus. Invest Ophthalmol Vis Sci 1978; 17(1): 63-5.
[PMID: 621128]
[11]
Kim JO, Hassard DTR. On the enzymology of the cornea. A new enzyme deficiency in keratoconus. Can J Ophthalmol 1972; 7(2): 176-80.
[PMID: 4670099]
[12]
Yue BYJT, Baum JL, Smith BD. Collagen synthesis by cultures of stromal cells from normal human and keratoconus corneas. Biochem Biophys Res Commun 1979; 86(3): 465-72.
[http://dx.doi.org/10.1016/0006-291X(79)91737-6] [PMID: 426795]
[13]
Belliveau MJ, Liao WN, Brownstein S, et al. Myxomatous corneal degeneration: a clinicopathological study of six cases and a review of the literature. Surv Ophthalmol 2012; 57(3): 264-71.
[http://dx.doi.org/10.1016/j.survophthal.2011.09.006] [PMID: 22370508]
[14]
Fontes BM, Ambrósio R Jr, Velarde GC, Nosé W. Corneal biomechanical evaluation in healthy thin corneas compared with matched keratoconus cases. Arq Bras Oftalmol 2011; 74(1): 13-6.
[http://dx.doi.org/10.1590/S0004-27492011000100003] [PMID: 21670900]
[15]
Shah S, Laiquzzaman M, Bhojwani R, Mantry S, Cunliffe I. Assessment of the biomechanical properties of the cornea with the ocular response analyzer in normal and keratoconic eyes. Invest Ophthalmol Vis Sci 2007; 48(7): 3026-31.
[http://dx.doi.org/10.1167/iovs.04-0694] [PMID: 17591868]
[16]
Glass DH, Roberts CJ, Litsky AS, Weber PA. A viscoelastic biomechanical model of the cornea describing the effect of viscosity and elasticity on hysteresis. Invest Ophthalmol Vis Sci 2008; 49(9): 3919-26.
[http://dx.doi.org/10.1167/iovs.07-1321] [PMID: 18539936]
[17]
Grayson M. Diseases of the cornea. St. Louis: C V Mosby 1979; pp. 257-61.
[18]
Dudakova L, Jirsova K. The impairment of lysyl oxidase in keratoconus and in keratoconus-associated disorders. J Neural Transm (Vienna) 2013; 120(6): 977-82.
[http://dx.doi.org/10.1007/s00702-013-0993-1] [PMID: 23653221]
[19]
Kaufman H, McDonald MB, Barron BA, Waltman SR. The cornea. New York: Churchill Livingstone 1988; pp. 194-5.
[20]
Rabinowitz YS. Keratoconus. Surv Ophthalmol 1998; 42(4): 297-319.
[http://dx.doi.org/10.1016/S0039-6257(97)00119-7] [PMID: 9493273]
[21]
Smith DS. Health care management of adults with Down syndrome. Am Fam Physician 2001; 64(6): 1031-8.
[PMID: 11578024]
[22]
Lichter H, Loya N, Sagie A, et al. Keratoconus and mitral valve prolapse. Am J Ophthalmol 2000; 129(5): 667-8.
[http://dx.doi.org/10.1016/S0002-9394(00)00371-8] [PMID: 10844063]
[23]
Javadi MA, Rafati N, Mohebi A, Poursalman MR, Forghani MR. Prevalence of keratoconus in patients with mitral valve prolapse. Bina J Ophthalmol 2005; 11: 40-4.


Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 16
ISSUE: 2
Year: 2020
Page: [147 - 152]
Pages: 6
DOI: 10.2174/1573403X15666191129100928
Price: $65

Article Metrics

PDF: 10