Background: There is a dearth of published information on the posterior perforated substance
as compared to the anterior perforated substance. We managed to glean facts about the posterior perforated
substance that can serve as a landmark for surgical operations in the adjacent regions of the midbrain
and the vessels passing through it. Moreover, the posterior perforated substance contains the interpeduncular
nucleus responsible for the mental state of the individual.
Objectives: 1) To describe the topography of the blood vessels supplying the posterior perforated substance
area from the surgical point of view; 2) to investigate the functions of the interpeduncular nucleus.
Methods: We assembled and analyzed results from source databases by Elsevier, NCBI MedLine, Scopus,
Scholar. Google and Embase. Each article was studied in detail for practically useful information
about the posterior perforated substance.
Results: The P1-segment perforating branches of the posterior cerebral artery supply the posterior perforated
substance. This area is especially vulnerable in the case of vascular pathologies. The posterior
communicating artery can block the surgeon’s view and impede maneuverability of the tool in the area
of the posterior perforated substance, which may be addressed using the separation technique, which can
lead to positive results. In addition, the medial habenula-interpeduncular nucleus in the posterior perforated
substance is associated with various addictions and psychiatric conditions.
Conclusion: The posterior perforated substance area is of great interest for surgical interventions. Future
studies of the interpeduncular nucleus anticipate the development of drugs to affect different types of
dependencies and some mental diseases.