Title:Exosomes and Bone Disease
VOLUME: 25 ISSUE: 42
Author(s):Su-Kang Shan, Xiao Lin, Fuxingzi Li, Feng Xu, Jia-Yu Zhong, Bei Guo, Yi Wang, Ming-Hui Zheng, Feng Wu and Ling-Qing Yuan*
Affiliation:Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Disease, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Disease, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Disease, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Disease, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Disease, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Disease, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Disease, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Disease, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, Department of Pathology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Disease, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan
Keywords:Exosomes, microRNAs, osteoporosis, osteoarthritis, fracture healing, regeneration.
Abstract:Exosomes, which mediate cell-to-cell communications and provide a novel insight into information
exchange, have drawn increasing attention in recent years. The homeostasis of bone metabolism is critical for
bone health. The most common bone diseases such as osteoporosis, osteoarthritis and bone fractures have apparent
correlations with exosomes. Accumulating evidence has suggested the potential regenerative capacities of
stem cell-derived exosomes. In this review, we summarise the pathophysiological mechanism, clinical picture and
therapeutic effects of exosomes in bone metabolism. We introduce the advantages and challenges in the application
of exosomes. Although the exact mechanisms remain unclear, miRNAs seem to play major roles in the
exosome.
