Nano-SnCl4/SiO2 as a Catalyst for One-Pot Synthesis of Substituted 1H-Pyrazoles as Antifungal and Cytotoxic Agents

Author(s): Soghra Khabnadideh, Zeinab Faghih, Leila Zamani*, Kamiar Zomorodian, Bi Bi Fatemeh Mirjalili, Hadi Moradi

Journal Name: Letters in Organic Chemistry

Volume 17 , Issue 6 , 2020

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Abstract:

A simple and efficient method was developed for the synthesis of pyrazole derivatives via a one-pot reaction of 1,3-diketone and substituted hydrazines in the presence of nano-SnCl4/SiO2 as a mild catalyst. A series of some pyrazole derivatives (P1-P11) was synthesized and evaluated as antifungal and anti-cancer agents. Compounds P10 and P11 were demonstrated. The antimicrobial activities of the synthetic compounds showed that compounds P10 and P11 most excellently inhibited the growth of dermatophytes or Aspergillus species, respectively. Therefore, the cytotoxic activities of these compounds on two human cancer cell lines, A549 (lung cancer) and MCF-7 (breast cancer) were further assessed. Hence, results demonstrated that beside antifungal activity, P10 had also desirable cytotoxic effect on investigated cancerous cell lines, even higher than cisplatin.

Keywords: Pyrazole, Nano-SnCl4/SiO2, antifungal, antibacterial, cytotoxic activity, antimicrobial activities.

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Article Details

VOLUME: 17
ISSUE: 6
Year: 2020
Page: [459 - 465]
Pages: 7
DOI: 10.2174/1570178617666191127104622
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