A simple and efficient method was developed for the synthesis of pyrazole derivatives via a
one-pot reaction of 1,3-diketone and substituted hydrazines in the presence of nano-SnCl4/SiO2 as a
mild catalyst. A series of some pyrazole derivatives (P1-P11) was synthesized and evaluated as antifungal
and anti-cancer agents. Compounds P10 and P11 were demonstrated. The antimicrobial activities
of the synthetic compounds showed that compounds P10 and P11 most excellently inhibited the
growth of dermatophytes or Aspergillus species, respectively. Therefore, the cytotoxic activities of these
compounds on two human cancer cell lines, A549 (lung cancer) and MCF-7 (breast cancer) were
further assessed. Hence, results demonstrated that beside antifungal activity, P10 had also desirable cytotoxic
effect on investigated cancerous cell lines, even higher than cisplatin.
Keywords: Pyrazole, Nano-SnCl4/SiO2, antifungal, antibacterial, cytotoxic activity, antimicrobial activities.
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