We have successfully explored the potential MoO3 nanoparticles as a heterogeneous catalyst
for the cyclocondensation of hydrazines/hydrazides with 1,3-dicarbonyl compound in aqueousalcoholic
medium at room temperature. The present method has been developed using green chemistry
measures and offers a range of N-substituted pyrazoles with moderate to excellent yields. Utilization of
non-toxic catalyst, wide substrate scope and environmentally benign reaction medium are the important
features of the developed protocol. Interestingly, MoO3 nanocatalyst can easily be recovered from the
reaction mixture and showed excellent reusability with a modest change in product yield. We have reported
herein the synthetic pathway with less disastrous effect in the atmosphere.
Keywords: Pyrazoles, MoO3 nanoparticles, cosolvent, Aqueous alcoholic medium, heterogeneous catalysis, reusability.
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