MoO3 Nanoparticles as an Efficient Catalyst for the Synthesis of Pyrazoles in Aqueous-alcoholic Medium at Room Temperature

Author(s): Sonatai Patil*, Ananda Mane, Savita Dhongade-Desai

Journal Name: Letters in Organic Chemistry

Volume 17 , Issue 9 , 2020

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Graphical Abstract:


We have successfully explored the potential MoO3 nanoparticles as a heterogeneous catalyst for the cyclocondensation of hydrazines/hydrazides with 1,3-dicarbonyl compound in aqueousalcoholic medium at room temperature. The present method has been developed using green chemistry measures and offers a range of N-substituted pyrazoles with moderate to excellent yields. Utilization of non-toxic catalyst, wide substrate scope and environmentally benign reaction medium are the important features of the developed protocol. Interestingly, MoO3 nanocatalyst can easily be recovered from the reaction mixture and showed excellent reusability with a modest change in product yield. We have reported herein the synthetic pathway with less disastrous effect in the atmosphere.

Keywords: Pyrazoles, MoO3 nanoparticles, cosolvent, Aqueous alcoholic medium, heterogeneous catalysis, reusability.

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Article Details

Year: 2020
Page: [694 - 703]
Pages: 10
DOI: 10.2174/1570178617666191127103433
Price: $65

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