Metal-free synthesis of pyrimidinone (alky/aryl) via Biginelli reaction in the presence of
aqueous sodium dichloroiodate (NaICl2) was studied under reflux conditions. Herein, we first time report
the synthesis of the aliphatic Biginelli product by using aliphatic aldehyde, cyclopentane, and urea.
Several aromatic and heteroaromatic aldehydes were studied for the confirmation of the wide applicability
of aq. NaICl2 for the synthesis of corresponding Biginelli products. The obtained desired products
provide good to excellent yield.
Keywords: Three-component, pyrimidinone, bignelli reaction, sodium iodine dichloride, aliphatic aldehyde, cyclopentane.
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