Oral Modified Drug Release Solid Dosage Form with Special Reference to Design; An Overview

Author(s): Senthilkumar Murugesan, Byran Gowramma*, Kaviarasan Lakshmanan, Veera Venkata Satyanarayana Reddy Karri, Arun Radhakrishnan

Journal Name: Current Drug Research Reviews
Formerly: Current Drug Abuse Reviews

Volume 12 , Issue 1 , 2020

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

Oral drug delivery is the most widely utilized route of administration among all the routes that have been explored for systemic delivery of drugs via pharmaceutical products of different dosage form and this oral route provides maximum active surface area among all drug delivery system for administration of various drugs. The attractiveness of these dosage forms is due to awareness of toxicity and ineffectiveness of drugs when administered by oral conventional method in the form of tablets and capsules. Usually, conventional dosage form produces wide range of fluctuation in drug concentration in the bloodstream and tissues with consequent undesirable toxicity and poor efficiency. The maintenance of concentration of drug in plasma within therapeutic index is very critical for effective treatment. These factors as well as factors such as repetitive dosing and unpredictable absorption lead to the concept of oral modified drug delivery systems like Sustained release, prolonged release, modified release, extended release. These formulations are used to identify drug delivery systems that are designed to achieve or extend therapeutic effect by continuously releasing medication over an extended period of time after administration of a single dose. This review describes the basic information regarding modified release dosage form like designed to release their medication in controlled manner, criteria for selecting modified release dosage form and factors influencing the dosage and release pattern.

Keywords: Oral drug delivery, conventional dosage form, therapeutic index, oral modified drug delivery systems, plasma, toxicity, capsules.

[1]
Bose S, Kaur A, Sharma SK. A review on advances of sustained release drug delivery system. Int Res J Pharm 2013; 4(6): 1-5.
[http://dx.doi.org/10.7897/2230-8407.04601]
[2]
Diwedi RO, Alexandar A, Chandrasekar MJ. Preparation and in vitro evaluation of sustained release tablet formulations of metformin HCL. J Pharml Clin Res 2012; 5(1): 1-5.
[3]
Hemnani M, Patel U, Patel G, Daslaniya D, Shah A, Bhimani B. Matrix tablet: A tool of controlled drug delivery. Am J Pharm Tech Res 2011; 1(4): 127-43.
[4]
Robinson JR, Jantzen GM. Sustained-and controlled-release drug-delivery systems Modern pharmaceutics. 4th ed. CRC Press 2002.
[http://dx.doi.org/10.1201/9780824744694.ch15]
[5]
Verma RK, Mishra B, Garg S. Osmotically controlled oral drug delivery. Drug Dev Ind Pharm 2000; 26(7): 695-708.
[http://dx.doi.org/10.1081/DDC-100101287] [PMID: 10872087]
[6]
Dokoumetzidis A, Macheras P. A century of dissolution research: From Noyes and Whitney to the biopharmaceutics classification system. Int J Pharm 2006; 321(1-2): 1-11.
[http://dx.doi.org/10.1016/j.ijpharm.2006.07.011] [PMID: 16920290]
[7]
Wu F, Jin T. Polymer-based sustained-release dosage forms for protein drugs, challenges, and recent advances. AAPS PharmSciTech 2008; 9(4): 1218-29.
[http://dx.doi.org/10.1208/s12249-008-9148-3] [PMID: 19085110]
[8]
Karode NP, Prajapati VD, Solanki HK, Jani GK. Sustained release injectable formulations: Its rationale, recent progress and advancement. J Pharm Res 2017; 16(3): 282-9.
[9]
Anal AK, Singh H. Recent advances in microencapsulation of probiotics for industrial applications and targeted delivery. Trends Food Sci Technol 2007; 18: 240-51.
[http://dx.doi.org/10.1016/j.tifs.2007.01.004]
[10]
Mathir ZM, Dangor CM, Govender T, Chetty DJ. In vitro characterization of a controlled-release chlorpheniramine maleate delivery system prepared by the air-suspension technique. J Microencapsul 1997; 14(6): 743-51.
[http://dx.doi.org/10.3109/02652049709006824] [PMID: 9394255]
[11]
Ratnaparkhi MP, Gupta JP. Sustained release oral drug delivery system- An overview. IJPRR 2013; 2(3): 11-22.
[12]
Rout SK, Kar DM. A brief review on modified release solid dosage form with special reference to design. Human J 2015; 2(2): 25-40.
[13]
Gandhi A, Kumar H. Recent trends in sustained release drug delivery system. IJIMS 2014; 1(6): 122-34.
[14]
Anka RA, Narasimha RV, Seetha DA, Anil K, Vasu NV, Rajesh A. Oral controlled release drug delivery system: An overview. Int J Pharm Cheml Res 2015; 1(1): 6-16.
[15]
Samita G, Gaurav K. Fast dissolving drug delivery and its technologies. Pharm Innov 2012; 1(2): 34-9.
[16]
Jayanthi B, Manna PK, Madhusudhan S, Mohanta GP, Manavalan R. Per oral extended release products- An overview. J Appl Pharm Sci 2011; 1(2): 50-5.
[17]
Kawashima Y, Ohno H, Takenaka H. Preparation of spherical matrixes of prolonged-release drugs from liquid suspension. J Pharm Sci 1981; 70(8): 913-6.
[http://dx.doi.org/10.1002/jps.2600700821] [PMID: 7310663]
[18]
Mamidala RK, Ramana V, Sandeep G, et al. Factors influencing the design and performance of oral sustained/controlled release dosage forms. Int J Pharm Sci Nanotech 2009; 1: 583-94.
[19]
Mali RR, Goel V, Gupta S. Novel study in sustained release drug delivery system: A review. Int J Pharm Med Res 2015; 3(2): 204-15.
[20]
Nagarani B, Ashwin Kumar K, Julapally D. A review on controlled drug delivery system. Int J Appl Pharmaceut 2014; 2: 1555-86.
[21]
Bharagava A, Rathore RPS, Tanwar YS, Gupta S. Oral sustained release dosage form: An opportunity to prolong the release of drug. Int J Appl Pharmaceut Biomed Sci 2013; 3: 7-14.
[22]
Mehta RM. Pharmaceutics. New Delhi: Vallabh Prakashan 2002; pp. 258-65.
[23]
Tahara K, Yamamoto K, Nishihata T. Overall mechanism behind matrix Sustained Release (SR) tablets prepared with hydroxypropyl methylcellulose 2910. J Cond Rel 1995; 35(1): 59-66.
[http://dx.doi.org/10.1016/0168-3659(95)00021-Y]
[24]
Tønnesen HH, Karlsen J. Alginate in drug delivery systems. Drug Dev Ind Pharm 2002; 28(6): 621-30.
[http://dx.doi.org/10.1081/DDC-120003853] [PMID: 12149954]
[25]
Pearnchob N, Siepmann J, Bodmeier R. Pharmaceutical applications of shellac: Moisture-protective and taste-masking coatings and extended-release matrix tablets. Drug Dev Ind Pharm 2003; 29(8): 925-38.
[http://dx.doi.org/10.1081/DDC-120024188] [PMID: 14570313]
[26]
Sungthongjeen S, Pitaksuteepong T, Somsiri A, Sriamornsak P. Studies on pectins as potential hydrogel matrices for controlled-release drug delivery. Drug Dev Ind Pharm 1999; 25(12): 1271-6.
[http://dx.doi.org/10.1081/DDC-100102298] [PMID: 10612023]
[27]
Krishna KV, Reddy CH, Srikanth S. A review on microsphere for novel drug delivery system. Int J of Res Pharm Chem 2013; 2013: 763-7.
[28]
Costa P, Sousa LJM. Modeling and comparison of dissolution profiles. Eur J Pharm Sci 2001; 13(2): 123-33.
[http://dx.doi.org/10.1016/S0928-0987(01)00095-1] [PMID: 11297896]
[29]
Cohen DS, Erneaux T. Free boundary problems in controlled release pharmaceuticals. J Appl Math 1988; 1988: 1451-65.
[30]
Varelas CG, Dixon DG, Steiner CA. Zero-order release from biphasic polymer hydrogels. J Control Release 1995; 1: 185-92.
[http://dx.doi.org/10.1016/0168-3659(94)00085-9]
[31]
Ahmed I, Roni MA, Kibria G, Islam MR, Jalil R. In vitro release kinetics study of ambroxol hydrochloride pellets developed by extrusion spheronisation technique followed by acrylic polymer coating. Dhaka Uni J Pharmaceut Sci 2008; 1: 75-81.
[32]
Modi SA, Gaikwad PD, Bankar VH, et al. Sustained release drug delivery system: A review. Int J Pharm Res Dev 2011; 2: 147-60.
[33]
Bhowmik D. Matrix drug delivery system, recent trends in sustained release matrix drug delivery system- An overview. J Pharm 2009; 1: 20-8.
[34]
Patel CJ, Satyanand T. Novel sustained release drug delivery: A modern review. J Apd Pharmaceut 2014; 1: 115-9.
[35]
Misa R, Waghmare A, Aqueel S. Matrix tablet: A promising technique for controlled drug delivery. Indo Ama J Pharm Res 2013; 2013: 3791-805.
[36]
Agarwal G, Agarwal S, Karar PK, Shagun G. Oral sustained release tablets: An overview with a special emphasis on matrix tablet. AJADD 2017; 5(2): 64-76.
[37]
Kamboj S, Saroha K, Goel M, Madhu C. Sustained release drug delivery system: An overview. J Pharm (Cairo) 2013; 1: 169-81.
[38]
Liberman HA, Lachmann L, Shwartz JB. Pharmaceutical dosage forms: Tablets. J Pharm (Cairo) 1990; 1: 285-327.
[39]
Gupta AK, Mittal A, Jha KK. Fast dissolving tablet- A review. The pharmaceutical innovation. Int J Biomed Sci 2012; 1: 1-7.
[40]
Kaur T, Gill B, Kumar S, Gupta GD. Mouth dissolving tablets: A novel approach to drug delivery. Int J Cur Pharm Res 2011; 2: 1-7.
[41]
Prasanth VV, Chakraborthy A, Moy S, Mathew T, Mathapan R. Microspheres an overview. Int J Res Pharm Biomed Sci 2011; 2: 332-8.
[42]
Maderuelo C, Zarzuelo A, Lanao JM. Critical factors in the release of drugs from sustained release hydrophilic matrices. J Control Release 2011; 154(1): 2-19.
[http://dx.doi.org/10.1016/j.jconrel.2011.04.002] [PMID: 21497624]
[43]
Nokhodchi A, Raja S, Patel P, Asare-Addo K. The role of oral controlled release matrix tablets in drug delivery systems. Bioimpacts 2012; 2(4): 175-87.
[PMID: 23678458]
[44]
Suvakanta D, Padala NM, Lilakanta N, Prasanta C. Drug release from controlled drug delivery systems, acta poloniae pharmaceuticals. Drug Res 2010; 2010: 217-23.
[45]
Patel KK, Patel MS, Bhatt NM. An overview: Extended release matrix technology. Int J Pharmal Chem Scis 2012; 2012: 112-5.
[46]
Gautam S, Mahveer S. Review: In-vitro drug release characterization models. Int J Pharm Stu Res 2011; 2: 77-84.
[47]
Rao Raghavendra NG, Raj PRK, Nayak S. Review on matrix tablet as sustained release. Int J Pharmaceut Res Allied Sci 2013; 2: 1700-17.
[48]
Higuchi T. Mechanism of sustained action medication, theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci 1963; 52: 1145-9.
[http://dx.doi.org/10.1002/jps.2600521210] [PMID: 14088963]
[49]
Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. Mechanisms of solute release from porous hydrophilic polymers. Int J Pharm 1983; 2: 25-35.
[http://dx.doi.org/10.1016/0378-5173(83)90064-9]
[50]
Kar RK, Mohapatra S, Barik BB. Design and characterization of controlled release matrix tablets of Zidovudine. Asian J Pharm Clinical Res 2009; 2: 54-61.
[51]
Anoop KS. Isolation, characterization and formulation properties of a new plant gum obtained from Mangifera indica. Int J Pharm Biomed Res 2010; 1(2): 35-41.
[52]
Gurny R, Doelker E, Peppas NA. Modelling of sustained release of water-soluble drugs from porous, hydrophobic polymers. Biomaterials 1982; 3(1): 27-32.
[http://dx.doi.org/10.1016/0142-9612(82)90057-6] [PMID: 7066463]
[53]
Chauhan MJ, Patel SA. A concise review on sustained drug delivery system and its opportunities. Am J Pharmtech Res 2012; 2(2): 227-38.
[54]
Shah R, Magdum C, Patil SK, Chougule DD, Naikwade N. Validated spectroscopic method for estimation of aceclofenac from tablet formulation. Res J Pharm Tech 2008; 1: 430-2.
[55]
Nidhi RM, Kaur V, Han SS, Sharma S, Mishra N. Microparticles as controlled drug delivery carrier for the treatment of ulcerative colitis: A brief review. Saudi Pharm J 2014; 24(4): 458-72.
[PMID: 27330377]
[56]
Chauhan MJ, Patel SA. A concise review on sustained drug delivery system and its opportunities. Am J Pharm Tech Res 2012; 2: 227-38.


Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 12
ISSUE: 1
Year: 2020
Page: [16 - 25]
Pages: 10
DOI: 10.2174/2589977511666191121094520

Article Metrics

PDF: 22
HTML: 2