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Current Drug Therapy

Editor-in-Chief

ISSN (Print): 1574-8855
ISSN (Online): 2212-3903

Review Article

An Updated Overview of The Complex Clinical Spectrum of Tourette Syndrome

Author(s): Natan Gadoth*

Volume 15, Issue 2, 2020

Page: [86 - 91] Pages: 6

DOI: 10.2174/1574885514666191120143747

Price: $65

Abstract

Background: Tourette syndrome is reflectively and quite erroneously associated by many as a syndrome with tics and swearing. However, the syndrome is a complex neuropsychiatric disorder consisting of features known as Tourette syndrome combined with several serious comorbidities justifying the quite recent term of Tourette disorder rather than “syndrome”. Unfortunately, the published literature is mostly dedicated to tics, while mentioning the comorbidities only briefly.

Objective: The study aimed to provide a brief description of the “many faces” of Tourette syndrome.

Methods: This study included a summary of the relevant published literature.

Results: The literature review provided indicates that this rare neuropsychiatric clinical syndrome is more a multidisciplinary “disorder” rather than a” syndrome”.

Conclusion: Patients with Tourette disorder should be evaluated and treated by a multidisciplinary team.

Keywords: Tourette Syndrome, tics, coprolalia, self-mutilation, ADHD, OCD, sleep.

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[1]
Gadoth N. Gilles de la Tourette’s syndrome. Harefuah 1974; 86(7): 371-3.
[PMID: 4527018]
[2]
Kurlan R, McDermott MP, Deeley C, et al. Prevalence of tics in schoolchildren and association with placement in special education. Neurology 2001; 57(8): 1383-8.
[http://dx.doi.org/10.1212/WNL.57.8.1383] [PMID: 11673576]
[3]
Snider LA, Seligman LD, Ketchen BR, et al. Tics and problem behaviors in schoolchildren: prevalence, characterization, and associations. Pediatrics 2002; 110(2 Pt 1): 331-6.
[http://dx.doi.org/10.1542/peds.110.2.331] [PMID: 12165586]
[4]
Linazasoro G, Van Blercom N, de Zárate CO. Prevalence of tic disorder in two schools in the Basque country: Results and methodological caveats. Mov Disord 2006; 21(12): 2106-9.
[http://dx.doi.org/10.1002/mds.21117] [PMID: 17013915]
[5]
Cubo E, Gabriel y Galán JM, Villaverde VA, et al. Prevalence of tics in schoolchildren in central Spain: a population-based study. Pediatr Neurol 2011; 45(2): 100-8.
[http://dx.doi.org/10.1016/j.pediatrneurol.2011.03.003] [PMID: 21763950]
[6]
Knight T, Steeves T, Day L, Lowerison M, Jette N, Pringsheim T. Prevalence of tic disorders: a systematic review and meta-analysis. Pediatr Neurol 2012; 47(2): 77-90.
[http://dx.doi.org/10.1016/j.pediatrneurol.2012.05.002] [PMID: 22759682]
[7]
Shapiro AK, Shapiro ES, Young JG, Feinberg TE, Eds. Gilles de la Tourette Syndrome. 2nd ed. New York, NY: Raven Press 1988; p. 58.
[8]
De la Tourette G. copralalie. Arch Neurol 1885; 9: 158-200.
[9]
Murray TJ. Dr Samuel Johnson’s movement disorder. BMJ 1979; 1(6178): 1610-4.
[http://dx.doi.org/10.1136/bmj.1.6178.1610] [PMID: 380753]
[10]
Robertson MM. The prevalence and epidemiology of Gilles de la Tourette syndrome. Part 1: the epidemiological and prevalence studies. J Psychosom Res 2008; 65(5): 461-72.
[http://dx.doi.org/10.1016/j.jpsychores.2008.03.006] [PMID: 18940377]
[11]
Scharf JM, Miller LL, Gauvin CA, Alabiso J, Mathews CA, Ben-Shlomo Y. Population prevalence of Tourette syndrome: a systematic review and meta-analysis. Mov Disord 2015; 30(2): 221-8.
[http://dx.doi.org/10.1002/mds.26089] [PMID: 25487709]
[12]
Jankovic J, Kurlan R. Tourette syndrome: evolving concepts. Mov Disord 2011; 26(6): 1149-56.
[http://dx.doi.org/10.1002/mds.23618] [PMID: 21484868]
[13]
Walkup JT, LaBuda MC, Singer HS, Brown J, Riddle MA, Hurko O. Family study and segregation analysis of Tourette syndrome: evidence for a mixed model of inheritance. Am J Hum Genet 1996; 59(3): 684-93.
[PMID: 8751870]
[14]
O’Rourke JA, Scharf JM, Yu D, Pauls DL. The genetics of Tourette syndrome: a review. J Psychosom Res 2009; 67(6): 533-45.
[http://dx.doi.org/10.1016/j.jpsychores.2009.06.006] [PMID: 19913658]
[15]
Grados MA, Mathews CA. Clinical phenomenology and phenotype variability in Tourette syndrome. J Psychosom Res 2009; 67(6): 491-6.
[http://dx.doi.org/10.1016/j.jpsychores.2009.07.011] [PMID: 19913653]
[16]
Mol Debes NM, Hjalgrim H, Skov L. Validation of the presence of comorbidities in a Danish clinical cohort of children with Tourette syndrome. J Child Neurol 2008; 23(9): 1017-27.
[http://dx.doi.org/10.1177/0883073808316370] [PMID: 18827268]
[17]
American psychiatric association Diagnostic and statistical manual of mental disorders. 5th ed. Arlington, VA: American Psychiatric Association 2013.
[18]
Cavanna AE. Improved criteria for the diagnosis of tic disorders in DSM-5. Future Neurol 2014; 9: 251-3.
[http://dx.doi.org/10.2217/fnl.14.17]
[19]
Conelea CA, Woods DW, Zinner SH, et al. Exploring the impact of chronic tic disorders on youth: results from the Tourette syndrome impact survey. Child Psychiatry Hum Dev 2011; 42(2): 219-42.
[http://dx.doi.org/10.1007/s10578-010-0211-4] [PMID: 21046225]
[20]
Mahler MS, Rangell L. A psychosomatic study of maladie des tics (Gilles de la Tourette’s disease). Psych Quar 1943; 17: 579-603.
[http://dx.doi.org/10.1007/BF01561841]
[21]
Caprini G, Maloti V. Un grave sindrome ticcosa guarita con haloperidol. Riv Sper Fren 1961; 85: 191-6.
[22]
Seignot JN. A case of tic of Gilles de la Tourette cured by R 1625. Ann Med Psychol 1961; 119(1): 578-9.
[PMID: 13749803]
[23]
Challas G, Brauer W. Tourette’s disease: relief of symptoms with R1625. Am J Psychiatry 1963; 120: 283-4.
[http://dx.doi.org/10.1176/ajp.120.3.283] [PMID: 14019908]
[24]
Chapel JL, Brown N, Jenkins RL. Tourette disease: symptomatic relief with haloperidol. Am J Psychiatry 1964; 121: 608-10.
[http://dx.doi.org/10.1176/ajp.121.6.608] [PMID: 14239470]
[25]
Shapiro AK, Shapiro E. Treatment of Gilles de la Tourette’s syndrome with haloperidol. Br J Psychiatry 1968; 114(508): 345-50.
[http://dx.doi.org/10.1192/bjp.114.508.345] [PMID: 4384341]
[26]
Bruun RD. Gilles de la Tourette’s syndrome. An overview of clinical experience. J Am Acad Child Psychiatry 1984; 23(2): 126-33.
[http://dx.doi.org/10.1097/00004583-198403000-00002] [PMID: 6585414]
[27]
Glaze DG, Frost JD Jr, Jankovic J. Sleep in Gilles de la Tourette’s syndrome: disorder of arousal. Neurology 1983; 33(5): 586-92.
[http://dx.doi.org/10.1212/WNL.33.5.586] [PMID: 6573576]
[28]
Cohrs S, Rasch T, Altmeyer S, et al. Decreased sleep quality and increased sleep related movements in patients with Tourette’s syndrome. J Neurol Neurosurg Psychiatry 2001; 70(2): 192-7.
[http://dx.doi.org/10.1136/jnnp.70.2.192] [PMID: 11160467]
[29]
Cohen AJ, Leckman JF. Sensory phenomena associated with Gilles de la Tourette’s syndrome. J Clin Psychiatry 1992; 53(9): 319-23.
[PMID: 1517194]
[30]
Freeman RD, Zinner SH, Müller-Vahl KR, et al. Coprophenomena in Tourette syndrome. Dev Med Child Neurol 2009; 51(3): 218-27.
[http://dx.doi.org/10.1111/j.1469-8749.2008.03135.x] [PMID: 19183216]
[31]
Leckman JF, Bloch MH, Scahill L, King RA. Tourette syndrome: the self under siege. J Child Neurol 2006; 21(8): 642-9.
[http://dx.doi.org/10.1177/08830738060210081001] [PMID: 16970864]
[32]
Leckman JF, Bloch MH, Sukhodolsky DG, et al. Phenomenology of tics and sensory urges: The Self under siegeTourette syndrome. Oxford: Oxford University Press 2013; pp. 3-25.
[http://dx.doi.org/10.1093/med/9780199796267.003.0001]
[33]
Fat MJ, Sell E, Barrowman N, Doja A. Public perception of Tourette syndrome on YouTube. J Child Neurol 2012; 27(8): 1011-6.
[http://dx.doi.org/10.1177/0883073811432294] [PMID: 22821136]
[34]
Gadoth N, Mass E. Hereditary neuropathies with self-mutilation. J Pediatr Neurol 2004; 2: 205-11.
[35]
Robertson MM, Trimble MR, Lees AJ. Self-injurious behaviour and the Gilles de la Tourette syndrome: a clinical study and review of the literature. Psychol Med 1989; 19(3): 611-25.
[http://dx.doi.org/10.1017/S0033291700024211] [PMID: 2678199]
[36]
Freeman RD, Fast DK, Burd L, Kerbeshian J, Robertson MM, Sandor P. An international perspective on Tourette syndrome: selected findings from 3,500 individuals in 22 countries. Dev Med Child Neurol 2000; 42(7): 436-47.
[http://dx.doi.org/10.1017/S0012162200000839] [PMID: 10972415]
[37]
Robertson MM, Channon S, Baker J, Flynn D. The psychopathology of Gilles de la Tourette’s syndrome. A controlled study. Br J Psychiatry 1993; 162: 114-7.
[http://dx.doi.org/10.1192/bjp.162.1.114] [PMID: 8425124]
[38]
Lucas AR, Kauffman PE, Morris EM. Gilles de la Tourette’s disease. A clinical study of fifteen cases. J Am Acad Child Psychiatry 1967; 6(4): 700-22.
[http://dx.doi.org/10.1016/S0002-7138(09)61698-8] [PMID: 5251904]
[39]
Nichols PL, Chen T. Minimal brain dysfunction A prospective study. New Jersey, USA: Laurence Erlbaum Ass Pub 1981.
[40]
Rapin I. Children with brain dysfunction. New York: Raven Press 1982.
[41]
Shapiro AK, Shapiro ES, Bruun RD, Sweet RD. Gilles de la Tourette Syndrome. New York, NY: Raven Press 1978.

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