Background: Infertility is a major problem worldwide. Various strategies are being used to
develop better treatments for infertility and The most trending strategy is the stem cell therapy. In this
study, the literature on stem cell therapy for ovarian disorders is summarized with analysis of current
Objective: Different published studies on stem cell-based therapy for the treatment of various types of
ovarian insufficiency and disorders such as Premature Ovarian Insufficiency (POI) in the affected female
population in animal or human clinical studies are systematically reviewed.
Methods: We monitored five databases, including PubMed, Cochrane, Embase, Scopus, and ProQuest.
A comprehensive online search was done using the criteria targeting the application of stem cells in
animal models for menopause. Two independent reviewers carefully evaluated titles and abstracts of
studies. The stem cell type, source, dosage, route of administration were highlighted in various POI
animals models. Non-relevant and review articles were excluded.
Outcomes: 648 published studies were identified during the initial comprehensive search process from
which 41 were selected according to designed criteria. Based on our analysis, stem cells could accelerate
ovarian tissues rejuvenation, regulate systemic sex-related hormones levels and eventually increase
Conclusion: The evidence suggests that stem cell-based therapies could be considered as an alternative
modality to deal with women undergoing POI.