Consequences of Dicarbonyl Stress on Skeletal Muscle Proteins in Type 2 Diabetes

Author(s): Khurshid Ahmad, Sibhghatulla Shaikh, Eun Ju Lee, Yong-Ho Lee*, Inho Choi*

Journal Name: Current Protein & Peptide Science

Volume 21 , Issue 9 , 2020


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Abstract:

Skeletal muscle is the largest organ in the body and constitutes almost 40% of body mass. It is also the primary site of insulin-mediated glucose uptake, and skeletal muscle insulin resistance, that is, diminished response to insulin, is characteristic of Type 2 diabetes (T2DM). One of the foremost reasons posited to explain the etiology of T2DM involves the modification of proteins by dicarbonyl stress due to an unbalanced metabolism and accumulations of dicarbonyl metabolites. The elevated concentration of dicarbonyl metabolites (i.e., glyoxal, methylglyoxal, 3-deoxyglucosone) leads to DNA and protein modifications, causing cell/tissue dysfunctions in several metabolic diseases such as T2DM and other age-associated diseases. In this review, we recapitulated reported effects of dicarbonyl stress on skeletal muscle and associated extracellular proteins with emphasis on the impact of T2DM on skeletal muscle and provided a brief introduction to the prevention/inhibition of dicarbonyl stress.

Keywords: Skeletal muscle, insulin resistance, diabetes, reactive dicarbonyl and glycolytic intermediates, dicarbonyl stress, T2DM.

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Article Details

VOLUME: 21
ISSUE: 9
Year: 2020
Published on: 11 December, 2020
Page: [878 - 889]
Pages: 12
DOI: 10.2174/1389203720666191119100759
Price: $65

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