Sepsis is the leading cause of death in medical intensive care units, and thus represents a serious
healthcare problem worldwide. Sepsis is often caused by the aberrant host responses to infection, which induce
dysregulated inflammation that leads to life-threatening multiple organ failures. Mediators such as proinflammatory
cytokines that drive the sepsis pathogenesis have been extensively studied. Exosomes, biological
lipid bilayer nanoparticles secreted via the endosomal pathway of cells, have recently emerged as important cargos
that carry multiple mediators critical for the pathogenesis of sepsis-associated organ dysfunctions. Here we
will review current knowledge on the exosomes in sepsis and relevant inflammatory tissue injuries.
Keywords: Sepsis, septic shock, inflammatory tissue injury, exosome, extracellular vesicle, integrin, miRNA
Genschmer KR, Russell DW, Lal C, et al. Activated PMN exosomes: pathogenic entities causing matrix destruction and disease in the lung cell 2019; 176: 113-126.e15.
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