Exosomes in Sepsis and Inflammatory Tissue Injury

Author(s): Eun J. Park*, Michael G. Appiah, Phyoe K. Myint, Arong Gaowa, Eiji Kawamoto, Motomu Shimaoka*

Journal Name: Current Pharmaceutical Design

Volume 25 , Issue 42 , 2019


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Abstract:

Sepsis is the leading cause of death in medical intensive care units, and thus represents a serious healthcare problem worldwide. Sepsis is often caused by the aberrant host responses to infection, which induce dysregulated inflammation that leads to life-threatening multiple organ failures. Mediators such as proinflammatory cytokines that drive the sepsis pathogenesis have been extensively studied. Exosomes, biological lipid bilayer nanoparticles secreted via the endosomal pathway of cells, have recently emerged as important cargos that carry multiple mediators critical for the pathogenesis of sepsis-associated organ dysfunctions. Here we will review current knowledge on the exosomes in sepsis and relevant inflammatory tissue injuries.

Keywords: Sepsis, septic shock, inflammatory tissue injury, exosome, extracellular vesicle, integrin, miRNA

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Article Details

VOLUME: 25
ISSUE: 42
Year: 2019
Published on: 07 January, 2020
Page: [4486 - 4495]
Pages: 10
DOI: 10.2174/1381612825666191116125525
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