Synthesis of a New Dioxaspiro[bicyclo[3.3.1]nonane-oxabicyclo[6.2.0]deca- 1(10),8-dien-4-one Derivative Using Some Chemical Strategies

Author(s): Figueroa-Valverde Lauro*, Rosas-Nexticapa Marcela, Lopez-Ramos Maria, Diaz Cedillo Francisco, Mateu-Armand Virginia, Garcimarero-Espino E. Alejandra, Borges-Ballote Yaritza, Ortiz-Ake Yazmin.

Journal Name: Letters in Organic Chemistry

Volume 17 , Issue 5 , 2020

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Abstract:

There are several protocols for the preparation of bicyclic derivatives; however, some methods use dangerous and require special conditions. The aim of this study was to synthesize a new Dioxaspiro[ bicyclo[3.3.1]nonane-oxabicyclo[6.2.0]-deca-1(10), 8-dien-4-one (compound 8). Compound 8 was prepared using some reactions such as; i) etherification, ii) reduction, iii) amidation, iv) imination and v) 2+2 addition. The chemical structure of 8 and its intermediaries were completely characterized by spectroscopic techniques and elemental analysis. The synthesis showed a yield of 85% for compound 8. In this study, an easy method for the preparation of compound 8 is reported.

Keywords: Steroid, bicyclo, dioxaspiro, etherification, reduction, dienone.

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Article Details

VOLUME: 17
ISSUE: 5
Year: 2020
Page: [393 - 402]
Pages: 10
DOI: 10.2174/1570178617666191116123359
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