miR-21 and miR29-a: Potential Molecular Biomarkers for HPV Genotypes and Cervical Cancer Detection

(E-pub Ahead of Print)

Author(s): Sara Zamani, Seyed Masoud Hosseini, Amir Sohrabi*

Journal Name: MicroRNA

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Background and objective: This study aimed to assess miR21 and miR-29a diagnostic usefulness for HPV infection and Cervical Cancer (CC) detection.

Methods: miRs extraction has been performed on HPV-positive, CC and negative control of 43, 50 and 46 individuals, respectively. Expression level of miRs has been analyzed using Real Time RT-PCR.

Results: There was a correlation between the expression of miRs and the receiver operating characteristic (ROC) analysis in CC and HPV-positive patients.

Conclusion: The correlation between expressions of miRs is notable. ROC curve analysis could be applied in molecular diagnostic exposure for CC related to HPV infections.

Keywords: miR-21, miR-29a, HPV, Biomarker, Cervical Cancer.

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(E-pub Ahead of Print)
DOI: 10.2174/2211536609666191115110015

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