Does Placental Weight Affects Perinatal Outcome? A Prospective Case-control Study

Author(s): Naina Kumar*, Himani Agarwal

Journal Name: Current Women`s Health Reviews

Volume 16 , Issue 1 , 2020

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Graphical Abstract:


Background: Placenta plays a very important role in the growth and development of fetus.

Objective: To know the correlation between placental weight and perinatal outcome in term antenatal women.

Methods: Present prospective case-control study was conducted in the rural tertiary center of Northern India over one year (January-December 2018) on 1,118 term (≥37-≤42 weeks) antenatal women with singleton pregnancy fulfilling inclusion criteria with 559 women with high-risk pregnancy as cases and 559 low-risk pregnant women as controls. Placental weight, birth weight was measured immediately after delivery and compared between the two groups along with gestation, parity, fetal gender, and neonatal outcome. Statistical analysis was done using SPSS 22 version.

Results: Mean placental weight [481.98±67.83 gm vs. 499.47±59.59 gm (p=.000)] and birth weight [2.68±0.53 Kg vs. 2.88±0.4 Kg (p=.000)] was significantly lower in high risk as compared to lowrisk participants, whereas placental birth weight ratio was higher in high-risk cases [18.35±2.37 vs. 17.41±1.38 (p=.000)] respectively. Placental weight was positively correlated with birth weight and placental weight and birth weight increased with increasing gestation in both cases and controls. Male neonates had higher placental weight [492.74±68.24 gm vs. 488±58.8 gm (p=0.224)] and birth weight [2.81±0.5 Kg vs. 2.74±0.45 Kg (p=0.033)] as compared to females. Neonatal Intensive Care Unit admission was significantly associated with low placental and birth weight (p=.000).

Conclusion: There is a significant correlation between placental weight, birth weight and neonatal outcome, hence placental weight can be used as an indirect indicator of intrauterine fetal growth.

Keywords: Birth weight, gestation, neonate, perinatal, placenta, pregnancy.

Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Gilstrap LC III, Wenstrom KD. Williams Obstetrics. In: Implantation, embryogenesis and placental development. 2nd ed. New York: McGraw- Hill 2005; pp. 39-90.
Wallace JM, Bhattacharya S, Horgan GW. Gestational age, gender and parity specific centile charts for placental weight for singleton deliveries in Aberdeen, UK. Placenta 2013; 34(3): 269-74.
[] [PMID: 23332414]
Wallace JM. Adaptive maternal, placental and fetal responses to nutritional extremes in the pregnant adolescent: lessons from sheep. In: Mascie-Taylor CGN, Rosetta L, EdsReproduction and adaptation. Cambridge:University Press . 2011; pp. 112-27.
Salafia CM, Yampolsky M, Misra DP, et al. Placental surface shape, function, and effects of maternal and fetal vascular pathology. Placenta 2010; 31(11): 958-62.
[] [PMID: 20933281]
Janthanaphan M, Kor-Anantakul O, Geater A. Placental weight and its ratio to birth weight in normal pregnancy at Songkhlanagarind Hospital. J Med Assoc Thai 2006; 89(2): 130-7.
[PMID: 16578997]
Burton GJ, Charnock-Jones DS, Jauniaux E. Regulation of vascular growth and function in the human placenta. Reproduction 2009; 138(6): 895-902.
[] [PMID: 19470597]
Hutcheon JA, McNamara H, Platt RW, Benjamin A, Kramer MS. Placental weight for gestational age and adverse perinatal outcomes. Obstet Gynecol 2012; 119(6): 1251-8.
[] [PMID: 22617591]
McDonald CR, Darling AM, Liu E, et al. Angiogenic proteins, placental weight and perinatal outcomes among pregnant women in Tanzania. PLoS One 2016; 11(12)e0167716
Matsuda Y, Ogawa M, Nakai A, Hayashi M, Satoh S, Matsubara S. Fetal/Placental weight ratio in term Japanese pregnancy: its difference among gender, parity, and infant growth. Int J Med Sci 2015; 12(4): 301-5.
[] [PMID: 25897290]
Salavati N, Smies M, Ganzevoort W, et al. The possible role of placental morphometry in the detection of fetal growth restriction. Front Physiol 2019; 9: 1884.
[] [PMID: 30670983]
Lelic M, Bogdanovic G, Ramic S, Brkicevic E. Influence of maternal anemia during pregnancy on placenta and newborns. Med Arh 2014; 68(3): 184-7.
[] [PMID: 25195349]
Gauster M, Desoye G, Tötsch M, Hiden U. The placenta and gestational diabetes mellitus. Curr Diab Rep 2012; 12(1): 16-23.
[] [PMID: 22102097]
Silasi M, Cohen B, Karumanchi SA, Rana S. Abnormal placentation, angiogenic factors, and the pathogenesis of preeclampsia. Obstet Gynecol Clin North Am 2010; 37(2): 239-53.
[] [PMID: 20685551]
McNamara H, Hutcheon JA, Platt RW, Benjamin A, Kramer MS. Risk factors for high and low placental weight. Paediatr Perinat Epidemiol 2014; 28(2): 97-105.
[] [PMID: 24354883]
Matsuda Y, Itoh T, Itoh H, et al. Impact of placental weight and fetal/placental weight ratio Z score on fetal growth and the perinatal outcome. Int J Med Sci 2018; 15(5): 484-91.
[ eCollection 2018]
Perry IJ, Beevers DG, Whincup PH, Bareford D. Predictors of ratio of placental weight to fetal weight in multiethnic community. BMJ 1995; 310(6977): 436-9.
[] [PMID: 7873949]
Panti AA, Ekele BA, Nwobodo EI, Yakubu A. The relationship between the weight of the placenta and birth weight of the neonate in a Nigerian Hospital. Niger Med J 2012; 53(2): 80-4.
[] [PMID: 23271851]
Jain A, Sharma D, Sharma V, Baweja S, Jain R. Study of placental weight in normal and pre-eclamptic pregnancies and its correlation with birth weight. Int J Med Res Rev 2016; 4(4): 562-8.
Madkar C, Musale J, Deshpande H, Shitole R. A study of placental weight and birth weight ratio (Pw/Bw) and its effects on perinatal outcome. Indian J Obstet Gynaecol 2015; 2(1): 1-6.
Salih ShA, Omar AM. The relationship between the weight of the placenta and neonatal outcome. IOSR-JNHS 2017; 6(6): 1-8.
Adesina KT, Ogunlaja OO, Aboyeji AP, et al. Relationship between gross placental characteristics and perinatal outcome of low-risk singleton deliveries. Niger Postgrad Med J 2016; 23(4): 191-5.
[] [PMID: 28000639]
Kabir N, Kawser CA, Rahman F, Kabir ML, Rahman A. The relationship of placental weight with birth weight. Mymensingh Med J 2007; 16(2): 177-80.
[PMID: 17703155]
Sanin LH, López SR, Olivares ET, Terrazas MC, Silva MA, Carrillo ML. Relation between birth weight and placenta weight. Biol Neonate 2001; 80(2): 113-7.
[] [PMID: 11509810]
Mongelli M, Figueras F, Francis A, Gardosi J. A customized birthweight centile calculator developed for an Australian population. Aust N Z J Obstet Gynaecol 2007; 47(2): 128-31.
[] [PMID: 17355302]
Bonellie S, Chalmers J, Gray R, Greer I, Jarvis S, Williams C. Centile charts for birthweight for gestational age for Scottish singleton births. BMC Pregnancy Childbirth 2008; 8: 5.
[] [PMID: 18298810]
Kim HS, Cho SH, Kwon HS, Sohn IS, Hwang HS. The significance of placental ratios in pregnancies complicated by small for gestational age, preeclampsia, and gestational diabetes mellitus. Obstet Gynecol Sci 2014; 57(5): 358-66.
[] [PMID: 25264525]
Thompson JM, Irgens LM, Skjaerven R, Rasmussen S. Placenta weight percentile curves for singleton deliveries. BJOG 2007; 114(6): 715-20.
[] [PMID: 17516963]
Asgharnia M, Esmailpour N, Poorghorban M, Atrkar-Roshan Z. Placental weight and its association with maternal and neonatal characteristics. Acta Med Iran 2008; 46(6): 467-72.
Lonimitdee K, Prommas S. Placental weight for gestational age and adverse neonatal outcome at Bhumibol Adulyadej Hospital. Thai J Obstet Gynaecol 2015; 23(4): 211-5.
Ness RB, Bass D, Hill L, Klebanoff MA, Zhang J. Diagnostic test characteristics of placental weight in the prediction of small-for-gestational-age neonates. J Reprod Med 2007; 52(9): 793-800.
[PMID: 17939595]

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Article Details

Year: 2020
Published on: 12 November, 2019
Page: [52 - 59]
Pages: 8
DOI: 10.2174/1573404815666191113111447
Price: $65

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