Autophagy is a well-maintained process by which the cells recycle intracellular
materials to maintain homeostasis in various cellular functions. However, autophagy is a defensive
mechanism that maintains cell survival under antagonistic conditions, the induction
of the autophagic process may substantially lead to cell death. The conflicting roles of autophagy
including allowing cell survival or promoting cell death could have a troublesome impact
on the efficiency of chemotherapeutic agents. Accordingly, understanding the role of
autophagy in cancer is a vital need for its optimal manipulation in therapy.
Keywords: Autophagy, molecular regulation, cell death, cell survival, macroautophagy, microautophagy,
El-Shafey ES. Assessment of the effect of copper complex on autophagy in TNBC cells. Mauritius: Lambert Academic Publishing 2018.
El-Shafey ES, Elsherbiny ES. Assessment of vanadium complex cytotoxic effect on breast cancer Mauritius: Lambert academic publishing academy . 2019.
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