Dual Opposed Survival-supporting and Death-promoting Roles of Autophagy in Cancer Cells: A Concise Review

Author(s): Eman S. El-Shafey, Eslam S. Elsherbiny*

Journal Name: Current Chemical Biology

Volume 14 , Issue 1 , 2020


DOI : 10.2174/2212796813666191111142824

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Graphical Abstract:


Abstract:

Autophagy is a well-maintained process by which the cells recycle intracellular materials to maintain homeostasis in various cellular functions. However, autophagy is a defensive mechanism that maintains cell survival under antagonistic conditions, the induction of the autophagic process may substantially lead to cell death. The conflicting roles of autophagy including allowing cell survival or promoting cell death could have a troublesome impact on the efficiency of chemotherapeutic agents. Accordingly, understanding the role of autophagy in cancer is a vital need for its optimal manipulation in therapy.

Keywords: Autophagy, molecular regulation, cell death, cell survival, macroautophagy, microautophagy, chaperone-mediated autophagy.

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Article Details

VOLUME: 14
ISSUE: 1
Year: 2020
Page: [4 - 13]
Pages: 10
DOI: 10.2174/2212796813666191111142824

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