Background: Aspergillus Versicolor is a marine-derived fungus isolated from Hyrtios Erectus
Red Sea sponge.
Methods: The aim of this study was to carry out a pharmacological screening and investigation for the
in vitro biological activity (antioxidant, cholinergic, antidiabetic and anticancer) of Aspergillus Versicolor
crude extract’s active compounds by using different qualitative and quantitative methods.
Results: The present study results showed that Aspergillus Versicolor crude extracts contain 0.6 mg
total phenolic/mg crude extract. Aspergillus Versicolor also showed a potent antioxidative capacity by
decreasing the oxidation of ABTS. The anticancer and inhibitory effects of Aspergillus Versicolor crude
extracts on PTK and SHKI were found to be 75.29 % and 80.76%; respectively. The AChE inhibitory
assay revealed that Aspergillus Versicolor extracts had an inhibitory percentage of 86.67%. Furthermore,
the anti-inflammatory activity using COX1, COX2, TNF, and IL6 was 77.32, 85.21 %, 59.83%,
and 56.15%; respectively. Additionally, the anti-viral effect using reverse transcriptase enzyme showed
high antiviral activity with 92.10 %.
Conclusion: The current study confirmed that the Aspergillus versicolor crude extract and its active
constituents showed strong effects on diminishing the oxidative stress, neurodegenerative damage, antiinflammatory,
anti-cancer and anti-viral, suggesting their beneficial role as a promising fermented product
in the treatment of cancer, oxidative stress, Alzheimer's, anti-inflammatory and anti-viral diseases.