A Review: Synthesis and Medicinal Importance of Coumarins and their Analogues (Part II)

Author(s): Moustafa A. Gouda*, Belal H.M. Hussein, Amr El-Demerdash, Mona E. Ibrahim, Mohammed A. Salem, Mohamed H. Helal, Wafaa S. Hamama

Journal Name: Current Bioactive Compounds

Volume 16 , Issue 7 , 2020

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Graphical Abstract:


Coumarins are a set of polyphenolic compounds isolated from plant product tonka bean, coumarou in 1820. They belong to the family of benzopyrones, which includes benzene ring joined with the aid of a pyrone ring. Coumarins have attracted great attention of medicinal chemists and pharmacologists in recent years as they been confirmed to bear diverse pharmacological activities like antiinflammatory and analgesic, anti oxidant, anticancer, etc. This review highlights the method of preparation, chemical reactivity, and organic properties such as anti-inflammatory, anticoagulant, antioxidant, anticancer and analgesic activities, of coumarins and their analogues.

Keywords: Coumarins, synthesis, anti-inflammatory and analgesic activity, anticoagulant activity, antioxidant and anticancer activity, chloroacetyl chloride.

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Article Details

Year: 2020
Published on: 28 October, 2020
Page: [993 - 1008]
Pages: 16
DOI: 10.2174/1573407215666191111120604
Price: $65

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