Ischemic stroke, which is the fifth leading cause of death, is an attack in the brain due to
blockage of a brain artery. It occurs when a sudden loss of blood flow to the brain leads to a reduction
in the oxygen supply. A wide range of reasons have been found for ischemic stroke, including
high blood pressure and associated thrombosis. Suitable biomarker analysis followed by proper
treatment helps to prevent ischemic stroke. An aptamer is an artificial antibody generated against
various clinical biomarkers from a smaller molecule of a whole cell. Recently, several researchers
conducted biomarker analysis for ischemic stroke using aptamers. Furthermore, factor IX, which is a
blood clotting factor, is highly correlated with thrombosis and plays a role in ischemic stroke. In this
review, we summarized the potential role of aptamers in ischemic stroke by nanoscale analysis, and
factor IX was the distinct focus of this review.
Keywords: Ischemic stroke, aptamer, biomarker, factor IX, thrombosis, nanoscale analysis.
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