Thio-, seleno-substituted triazoles are useful scaffolds employed in the fields of
organic synthesis, medicinal chemistry, and material science. A number of synthetic approaches
to efficient formation of thio- and seleno-triazoles have been disclosed, including
the interception of copper(I) triazolides generated in-situ, cycloaddition of internal alkynes
(thio-, halo-, and metalated alkynes) to azides, and the coupling of azides and nonalkyne
substrates. This mini-review intends to summarize the synthetic methods toward
thio-, seleno-1,2,3-triazoles and the relative reaction mechanisms.