Regioselective Synthesis of Diverse Thio-, Seleno-substituted 1,2,3-Triazoles

Author(s): Lin-Lin Zhang, Qin-Pei Wu*, Zhi-Bin Xu

Journal Name: Current Organic Chemistry

Volume 23 , Issue 22 , 2019

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Abstract:

Thio-, seleno-substituted triazoles are useful scaffolds employed in the fields of organic synthesis, medicinal chemistry, and material science. A number of synthetic approaches to efficient formation of thio- and seleno-triazoles have been disclosed, including the interception of copper(I) triazolides generated in-situ, cycloaddition of internal alkynes (thio-, halo-, and metalated alkynes) to azides, and the coupling of azides and nonalkyne substrates. This mini-review intends to summarize the synthetic methods toward thio-, seleno-1,2,3-triazoles and the relative reaction mechanisms.

Keywords: Thioether, triazole, multi-component reaction, cycloaddition reaction, selenoether, regioselectivity.

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VOLUME: 23
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Year: 2019
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DOI: 10.2174/1385272823666191108101604
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