Excessive bone resorption has been recognized play a major role in the development of
bone-related diseases such as osteoporosis, rheumatoid arthritis, Paget's disease of bone, and cancer.
Phospholipase Cγ (PLCγ) family members PLCγ1 and PLCγ2 are critical regulators of signaling pathways
downstream of growth factor receptors, integrins, and immune complexes and play a crucial role
in osteoclast. Ca2+ signaling has been recognized as an essential pathway to the differentiation of osteoclasts.
With growing attention and research about natural occurring compounds, the therapeutic use
of natural active plant-derived products has been widely recognized in recent years. In this review, we
summarized the recent research on PLCγ signaling in bone marrow stem cells and the use of several
natural compounds that were proven to inhibit RANKL-mediated osteoclastogenesis via modulating
PLCγ signaling pathways.
Keywords: Phospholipase Cγ signaling, calcium signaling, osteoclast, natural occurring compounds, bone marrow stem cell,
Rights & PermissionsPrintExport