New Patent on Electrospinning for Increasing Rutin Loading in Nanofibers

Author(s): Na Li, Yongfang Qian*, Zhen Zhang, Ying Wang, Lihua Lve, Chunyan Wei

Journal Name: Recent Patents on Nanotechnology

Volume 14 , Issue 1 , 2020

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Graphical Abstract:


Background: The electrospinning and the bubble electrospinning provide facile ways for the fabrication of functional nanofibers by incorporating rutin/hydroxypropyl-β-cyclodextrin inclusion complex (RT/HP-β-CD-IC) in Polyvinyl Alcohol (PVA). Few patents on incorporation of rutin and cyclodextrin in nanofibers has been reported.

Objective: The study aimed at increasing the loading amount of rutin in the electrospun nanofibers to obtain ultraviolet resistant property.

Methods: Rutin was encapsulated in the cavity of RT/HP-β-CD and formed an inclusion complex. Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimeter (DSC) was used to verify the formation of inclusion complexes.

Results: The results showed that the inclusion between rutin and HP-β-CD had been successfully formed. The surface morphologies of nanofibrous membranes were characterized by Scanning Electron Microscope (SEM), which indicated that adding RT/HP-β-CD inclusion complexes had little influence on the morphologies and diameters of the fibers. Ultraviolet resistant results also confirmed the inclusion complex had increased the loading amount in the final nanofibrous mats, and thus had good ultraviolet resistant properties.

Conclusion: The formed inclusion complexes had obviously enhanced the loading amount of rutin in electrospun PVA nanofibers, indicating that encapsulation of rutin in the cavity of HP-β-CD is a good way to increase the loading amount.

Keywords: Electrospinning, hydroxypropyl-β-cyclodextrin, nanofiber, Rutin, hydrophobic cavity, biocompatible.

Aytac Z, Sen HS, Durgun E, Uyar T. Sulfisoxazole/cyclodextrin inclusion complex incorporated in electrospun hydroxypropyl cellulose nanofibers as drug delivery system. Colloids Surf B Biointerfaces 2015; 128: 331-8.
[] [PMID: 25769282]
Hossain MF, Gong RH, Rigout M. Optimization of the process variables for electrospinning of poly(ethylene oxide)-loaded hydroxypropyl-β-cyclodextrin nanofibres. J Textil Inst 2016; 107(1): 1-11.
Xie C, Li X, Luo X, et al. Release modulation and cytotoxicity of hydroxycamptothecin-loaded electrospun fibers with 2-hydroxypropyl-β-cyclodextrin inoculations. Int J Pharm 2010; 391(1-2): 55-64.
[] [PMID: 20170717]
Lee HW, Karim MR, Ji HM, et al. Electrospinning fabrication and characterization of Poly(vinyl alcohol)/montmorillonitenanofiber mats. J Appl Polym Sci 2009; 113: 1860-7.
Wang X, Yue T, Lee T. Development of Pleurocidin-poly(vinyl alcohol) electrospun antimicrobial nanofibers to retain antimicrobial activity in food system application. Food Control 2015; 54: 150-7.
Mahmoodi NM, Moktari-Shourijeh Z. Preparation of PVA-chitosan Blend Nanofiber and its dye removal ability from colored wastewater. Fibers Polym 2015; 6: 1861-9.
Wang P, He JH. Electrospun polyvinyl alcohol-milk nanofibers. Therm Sci 2013; 17: 1515-6.
Wang P, He JH. Electrospun polyvinyl alcohol-honey nanofibers. Therm Sci 2013; 17: 1549-50.
He CH, Li CW, Liu P, et al. Bubbfil spinning for fabrication of PVA nanofibers. Therm Sci 2015; 19: 743-6.
Arima H, Ashida H, Danno G. Rutin-enhanced antibacterial activities of flavonoids against Bacillus cereus and Salmonella enteritidis. Biosci Biotechnol Biochem 2002; 66(5): 1009-14.
[] [PMID: 12092809]
Suzuki T, Morishita T, Kim SJ, et al. Physiological roles of rutin in the buckwheat plant. Jpn Agric Res Q 2015; 49: 37-43.
Yin WX, Wang XY, Wand JH, Zhuang H, Sun K, Li L. FTIR study of rutin, quercetin and their metal complexes. J China Univ Min Tech 2009; 11: 884-8.
Yuan CZ, Shen CP, Wang P, et al. Belle Collaboration. Measurement of the e+e- -->pi+pi- J/psi cross section via initial-state radiation at Belle. Phys Rev Lett 2007; 99(18) 182004
[] [PMID: 17995399]
Hossain MF, Gong RH. Rigout Muriel. Preparation and characterization of poly(ethylene oxide)-loaded hydroxypropyl-β-cyclo-dextrin nanofibers. Polym Adv Technol 2015; 26(9): 1184-8.
Qian Y, Qi M, Zheng L, King MW, Lv L, Ye F. Incorporation of Rutin in Electrospun Pullulan/PVA Nanofibers for Novel UV-Resistant Properties. Materials (Basel) 2016; 9(7): 504.
[] [PMID: 28773621]
Kostyuk VA, Potapovich AI, Lulli D, et al. Modulation of human keratinocyte responses to solar UV by plant polyphenols as a basis for chemoprevention of non-melanoma skin cancers. Curr Med Chem 2013; 20(7): 869-79.
[PMID: 23210792]
Yu DN, Tian D, He JH. Snail-based nanofibers. Mater Lett 2018; 220: 5-7.
Tian D, Li XX, He JH. Self-assembly of macromolecules in a long and narrow tube. Therm Sci 2018; 22(4): 1659-64.
Tian D, Zhou CJ, He JH. Strength of bubble walls and the Hall–Petch effect in bubble-spinning 2018; 89(7) 004051751877067
Liu P, He JH. Geometrical potential: An explanation on of nanofibers wettability. Therm Sci 2018; 22(1A): 33-8.
Zhao L, Liu P, He JH. Sudden solvent evaporation in bubble electrospinning for fabrication of unsmooth nanofibers. Therm Sci 2017; 21(4): 1827-32.
Li Y, He JH. Fabrication and characterization of ZrO2 nanofibers by critical bubble electrospinning for high-temperature-resistant adsorption and separation. Adsorpt Sci Technol 2019; 37: 425-37.
Cheng TT, Xu L, Wang MD. Effect of surface active agent on bubble-electrospun polyacrylonitrile nanofibers. Therm Sci 2019; 23: 2481-7.
Shao ZB, Song YH, Xu L. Formation mechanism of highly aligned nanofibers by a modified bubble electrospinning. Therm Sci 2018; 22: 5-10.
Peng NB, Liu YQ, Xu L, et al. A Rachford-Rice like equation for solvent evaporation in the bubble electrospinning. Therm Sci 2018; 22: 1679-83.
He CH, Shen Y, Ji FY, et al. Taylor series solution for fractal Bratu-type equation arising in electrospinning process. Fractals 2020; 28(1) 2050011
He JH, Sun C. A variational principle for a thin film equation. J Math Chem 2019; 57(9): 2075-81.

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Article Details

Year: 2020
Page: [35 - 41]
Pages: 7
DOI: 10.2174/1872210513666191107101326
Price: $65

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