Background: The regulatory function of transcription factors on genes is not only related
to the location of binding genes and its related functions, but is also related to the methods of
Objective: It is necessary to study the regulation effects in different binding methods on target genes.
Methods: In this study, we provided a reliable theoretical basis for studying gene expression
regulation of co-binding transcription factors and further revealed the specific regulation of
transcription factor co-binding in cancer cells.
Results: Transcription factors tend to combine with other transcription factors in the regulatory
region to form a competitive or synergistic relationship to regulate target genes accurately.
Conclusion: We found that up-regulated genes in cancer cells were involved in the regulation of
their own immune system related to the normal cells.