Background and Aim: Dental caries is a communicable and the most prevalent infectious
disease worldwide. Salivary oxidative stress and antioxidants may play a pivotal role
in caries prevention, progression and pathogenesis. In this study, salivary superoxide dismutase,
peroxidase, glutathione peroxidase, catalase and uric acid levels were evaluated in dental caries.
Materials and Methods: One hundred male and female students in two groups (n=50) were subdivided
into caries-active and caries-free (25) groups. Whole saliva samples were collected in the
morning, and the salivary antioxidant levels were measured by a spectrophotometric assay. The
data were analyzed using SPSS.
Results: The caries-active group had higher peroxidase, uric acid, catalase and glutathione peroxidase
levels, and lower superoxide dismutase level as compared to the caries-free group. The comparison
between males and females showed lower peroxidase, catalase and uric acid levels and
higher glutathione peroxidase levels in the female group.
Conclusion: The caries-active group had altered salivary antioxidant levels. Therefore, it was
concluded that salivary antioxidants have significant effects on oral and dental health.