Solid lipid particles have a great potential in sustained drug delivery, the lipid
excipients are solid at room temperature with a slow degradation rate. Poly (D, L-lactic-coglycolic
acid) (PLGA) has been successfully clinically applied for the sustained delivery of
peptide drugs. A recent study showed the advantage of hybrid PLGA-lipid microparticles
(MPs) over PLGA MPs for the sustained delivery of peptide drug in vivo. In this paper, we
briefly present PLGA MPs, solid lipid MPs and PLGA lipid hybrid MP prepared by the
double emulsion method and the spray drying method and discuss the effects of excipients
on encapsulation efficiency of protein and peptide drugs in the MPs. The pros and cons of
PLGA MPs, solid lipid MPs and PLGA lipid hybrid MP as carriers for sustained delivery
of protein and peptide drugs are also discussed.
Keywords: Drug delivery, hybrid polymer-lipid microparticles, PLGA microparticles, protein and peptide
drugs, solid lipid microparticles, sustained release.
Tracy MA. Development and scale-up of a microsphere protein delivery system. Biotechnol Prog 1998; 14(1): 108-15.
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