Co-culture and Mechanical Stimulation on Mesenchymal Stem Cells and Chondrocytes for Cartilage Tissue Engineering

Author(s): Yawen Chen, Xinli Ouyang, Yide Wu, Shaojia Guo, Yongfang Xie*, Guohui Wang*

Journal Name: Current Stem Cell Research & Therapy

Volume 15 , Issue 1 , 2020


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Abstract:

Defects in articular cartilage injury and chronic osteoarthritis are very widespread and common, and the ability of injured cartilage to repair itself is limited. Stem cell-based cartilage tissue engineering provides a promising therapeutic option for articular cartilage damage. However, the application of the technique is limited by the number, source, proliferation, and differentiation of stem cells. The co-culture of mesenchymal stem cells and chondrocytes is available for cartilage tissue engineering, and mechanical stimulation is an important factor that should not be ignored. A combination of these two approaches, i.e., co-culture of mesenchymal stem cells and chondrocytes under mechanical stimulation, can provide sufficient quantity and quality of cells for cartilage tissue engineering, and when combined with scaffold materials and cytokines, this approach ultimately achieves the purpose of cartilage repair and reconstruction. In this review, we focus on the effects of co-culture and mechanical stimulation on mesenchymal stem cells and chondrocytes for articular cartilage tissue engineering. An in-depth understanding of the impact of co-culture and mechanical stimulation of mesenchymal stem cells and chondrocytes can facilitate the development of additional strategies for articular cartilage tissue engineering.

Keywords: Mesenchymal stem cells, chondrocytes, cartilage tissue engineering, co-culture, mechanical stimulation, chondrogenic differentiation.

[1]
Correa D, Lietman SA. Articular cartilage repair: Current needs, methods and research directions. Semin Cell Dev Biol 2017; 62: 67-77.
[http://dx.doi.org/10.1016/j.semcdb.2016.07.013] [PMID: 27422331]
[2]
Montgomery SR, Foster BD, Ngo SS, et al. Trends in the surgical treatment of articular cartilage defects of the knee in the United States. Knee Surg Sports Traumatol Arthrosc 2014; 22(9): 2070-5.
[http://dx.doi.org/10.1007/s00167-013-2614-9] [PMID: 23896943]
[3]
McCormick F, Harris JD, Abrams GD, et al. Trends in the surgical treatment of articular cartilage lesions in the United States: An analysis of a large private-payer database over a period of 8 years. Arthroscopy 2014; 30(2): 222-6.
[http://dx.doi.org/10.1016/j.arthro.2013.11.001] [PMID: 24485115]
[4]
Simon TM, Jackson DW. Articular cartilage: Injury pathways and treatment options. Sports Med Arthrosc Rev 2006; 14(3): 146-54.
[http://dx.doi.org/10.1097/00132585-200609000-00006] [PMID: 17135961]
[5]
Liu C, Li T, Yang Z, et al. Kartogenin enhanced chondrogenesis in cocultures of chondrocytes and bone mesenchymal stem cells. Tissue Eng Part A 2018; 24(11-12): 990-1000.
[http://dx.doi.org/10.1089/ten.tea.2017.0162] [PMID: 29281950]
[6]
Cooke ME, Allon AA, Cheng T, et al. Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy. Osteoarthritis Cartilage 2011; 19(10): 1210-8.
[http://dx.doi.org/10.1016/j.joca.2011.07.005] [PMID: 21816228]
[7]
Mitchell AC, Briquez PS, Hubbell JA, Cochran JR. Engineering growth factors for regenerative medicine applications. Acta Biomater 2016; 30: 1-12.
[http://dx.doi.org/10.1016/j.actbio.2015.11.007] [PMID: 26555377]
[8]
Middendorf JM, Griffin DJ, Shortkroff S, et al. Mechanical properties and structure-function relationships of human chondrocyte-seeded cartilage constructs after in vitro culture. J Orthop Res 2017; 35(10): 2298-306.
[http://dx.doi.org/10.1002/jor.23535] [PMID: 28169453]
[9]
Steward AJ, Kelly DJ. Mechanical regulation of mesenchymal stem cell differentiation. J Anat 2015; 227(6): 717-31.
[http://dx.doi.org/10.1111/joa.12243] [PMID: 25382217]
[10]
Xie Y, Liu X, Wang S, Wang M, Wang G. Proper mechanical stimulation improve the chondrogenic differentiation of mesenchymal stem cells: Improve the viscoelasticity and chondrogenic phenotype. Biomed Pharmacother 2019.115108935
[http://dx.doi.org/10.1016/j.biopha.2019.108935] [PMID: 31078039]
[11]
Baghaban Eslaminejad M, Malakooty Poor E. Mesenchymal stem cells as a potent cell source for articular cartilage regeneration. World J Stem Cells 2014; 6(3): 344-54.
[http://dx.doi.org/10.4252/wjsc.v6.i3.344] [PMID: 25126383]
[12]
Brittberg M, Gomoll AH, Canseco JA, Far J, Lind M, Hui J. Cartilage repair in the degenerative ageing knee. Acta Orthop 2016; 87(sup363): 26-38.
[http://dx.doi.org/10.1080/17453674.2016.1265877]
[13]
Zhang Y, Guo W, Wang M, et al. Co-culture systems-based strategies for articular cartilage tissue engineering. J Cell Physiol 2018; 233(3): 1940-51.
[http://dx.doi.org/10.1002/jcp.26020] [PMID: 28548713]
[14]
Mall NA, Harris JD, Cole BJ. Clinical evaluation and preoperative planning of articular cartilage lesions of the knee. J Am Acad Orthop Surg 2015; 23(10): 633-40.
[http://dx.doi.org/10.5435/JAAOS-D-14-00241] [PMID: 26377673]
[15]
Shafiee A, Kabiri M, Langroudi L, Soleimani M, Ai J. Evaluation and comparison of the in vitro characteristics and chondrogenic capacity of four adult stem/progenitor cells for cartilage cell-based repair. J Biomed Mater Res A 2016; 104(3): 600-10.
[http://dx.doi.org/10.1002/jbm.a.35603] [PMID: 26507473]
[16]
Musumeci G, Castrogiovanni P, Leonardi R, et al. New perspectives for articular cartilage repair treatment through tissue engineering: A contemporary review. World J Orthop 2014; 5(2): 80-8.
[http://dx.doi.org/10.5312/wjo.v5.i2.80] [PMID: 24829869]
[17]
Mobasheri A, Kalamegam G, Musumeci G, Batt ME. Chondrocyte and mesenchymal stem cell-based therapies for cartilage repair in osteoarthritis and related orthopaedic conditions. Maturitas 2014; 78(3): 188-98.
[http://dx.doi.org/10.1016/j.maturitas.2014.04.017] [PMID: 24855933]
[18]
Kuo CK, Li WJ, Mauck RL, Tuan RS. Cartilage tissue engineering: Its potential and uses. Curr Opin Rheumatol 2006; 18(1): 64-73.
[http://dx.doi.org/10.1097/01.bor.0000198005.88568.df] [PMID: 16344621]
[19]
Tuan RS, Chen AF, Klatt BA. Cartilage regeneration. J Am Acad Orthop Surg 2013; 21(5): 303-11.
[http://dx.doi.org/10.5435/JAAOS-21-05-303] [PMID: 23637149]
[20]
de Windt TS, Vonk LA, Slaper-Cortenbach IC, et al. Allogeneic mesenchymal stem cells stimulate cartilage regeneration and are safe for single-stage cartilage repair in humans upon mixture with recycled autologous chondrons. Stem Cells 2017; 35(1): 256-64.
[http://dx.doi.org/10.1002/stem.2475] [PMID: 27507787]
[21]
Park YB, Song M, Lee CH, Kim JA, Ha CW. Cartilage repair by human umbilical cord blood-derived mesenchymal stem cells with different hydrogels in a rat model. J Orthop Res 2015; 33(11): 1580-6.
[http://dx.doi.org/10.1002/jor.22950] [PMID: 26019012]
[22]
Wang L, Hou P, Jiang T, Wang ZB, Zhao YX, Wu K. Different sources of mesenchymal stem cells for the treatment of cartilage repair in knee joint. Zhongguo Gu Shang 2017; 30(6): 581-6.
[PMID: 29424184]
[23]
Mishra PJ, Banerjee D. Activation and differentiation of mesenchymal stem cells. Methods Mol Biol 2017; 1554: 201-9.
[http://dx.doi.org/10.1007/978-1-4939-6759-9_13] [PMID: 28185193]
[24]
Harrell CR, Jankovic MG, Fellabaum C, et al. Molecular mechanisms responsible for anti-inflammatory and immunosuppressive effects of mesenchymal stem cell-derived factors. Adv Exp Med Biol 2019; 1084: 187-206.
[http://dx.doi.org/10.1007/5584_2018_306] [PMID: 31175638]
[25]
Ullah I, Subbarao RB, Rho GJ. Human mesenchymal stem cells - current trends and future prospective. Biosci Rep 2015; 35(2)e00191
[http://dx.doi.org/10.1042/BSR20150025] [PMID: 25797907]
[26]
Tan AR, Hung CT. Concise review: Mesenchymal stem cells for functional cartilage tissue engineering: Taking cues from chondrocyte-based constructs. Stem Cells Transl Med 2017; 6(4): 1295-303.
[http://dx.doi.org/10.1002/sctm.16-0271] [PMID: 28177194]
[27]
Moghadam FH, Tayebi T, Dehghan M, et al. Differentiation of bone marrow mesenchymal stem cells into chondrocytes after short term culture in alkaline medium. Int J Hematol Oncol Stem Cell Res 2014; 8(4): 12-9.
[PMID: 25774263]
[28]
Szychlinska MA, Castrogiovanni P, Nsir H, et al. Engineered cartilage regeneration from adipose tissue derived-mesenchymal stem cells: A morphomolecular study on osteoblast, chondrocyte and apoptosis evaluation. Exp Cell Res 2017; 357(2): 222-35.
[http://dx.doi.org/10.1016/j.yexcr.2017.05.018] [PMID: 28529106]
[29]
Musumeci G, Mobasheri A, Trovato FM, et al. Biosynthesis of collagen I, II, RUNX2 and lubricin at different time points of chondrogenic differentiation in a 3D in vitro model of human mesenchymal stem cells derived from adipose tissue. Acta Histochem 2014; 116(8): 1407-17.
[http://dx.doi.org/10.1016/j.acthis.2014.09.008] [PMID: 25307495]
[30]
Araki S, Imai S, Ishigaki H, et al. Improved quality of cartilage repair by bone marrow mesenchymal stem cells for treatment of an osteochondral defect in a cynomolgus macaque model. Acta Orthop 2015; 86(1): 119-26.
[http://dx.doi.org/10.3109/17453674.2014.958807] [PMID: 25175660]
[31]
Lee JM, Ko JY, Kim HY, Park JW, Guilak F, Im GI. miR-892b Inhibits Hypertrophy by Targeting KLF10 in the Chondrogenesis of Mesenchymal Stem Cells. Mol Ther Nucleic Acids 2019; 17: 310-22.
[http://dx.doi.org/10.1016/j.omtn.2019.05.029] [PMID: 31284128]
[32]
Richardson SM, Kalamegam G, Pushparaj PN, et al. Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration. Methods 2016; 99: 69-80.
[http://dx.doi.org/10.1016/j.ymeth.2015.09.015] [PMID: 26384579]
[33]
Ridge SM, Sullivan FJ, Glynn SA. Mesenchymal stem cells: Key players in cancer progression. Mol Cancer 2017; 16(1): 31.
[http://dx.doi.org/10.1186/s12943-017-0597-8] [PMID: 28148268]
[34]
Meretoja VV, Dahlin RL, Kasper FK, Mikos AG. Enhanced chondrogenesis in co-cultures with articular chondrocytes and mesenchymal stem cells. Biomaterials 2012; 33(27): 6362-9.
[http://dx.doi.org/10.1016/j.biomaterials.2012.05.042] [PMID: 22695067]
[35]
Meretoja VV, Dahlin RL, Wright S, Kasper FK, Mikos AG. The effect of hypoxia on the chondrogenic differentiation of co-cultured articular chondrocytes and mesenchymal stem cells in scaffolds. Biomaterials 2013; 34(17): 4266-73.
[http://dx.doi.org/10.1016/j.biomaterials.2013.02.064] [PMID: 23489925]
[36]
Meretoja VV, Dahlin RL, Wright S, Kasper FK, Mikos AG. Articular chondrocyte redifferentiation in 3D co-cultures with mesenchymal stem cells. Tissue Eng Part C Methods 2014; 20(6): 514-23.
[http://dx.doi.org/10.1089/ten.tec.2013.0532] [PMID: 24387702]
[37]
Dahlin RL, Kinard LA, Lam J, et al. Articular chondrocytes and mesenchymal stem cells seeded on biodegradable scaffolds for the repair of cartilage in a rat osteochondral defect model. Biomaterials 2014; 35(26): 7460-9.
[http://dx.doi.org/10.1016/j.biomaterials.2014.05.055] [PMID: 24927682]
[38]
Dahlin RL, Ni M, Meretoja VV, Kasper FK, Mikos AG. TGF-β3-induced chondrogenesis in co-cultures of chondrocytes and mesenchymal stem cells on biodegradable scaffolds. Biomaterials 2014; 35(1): 123-32.
[http://dx.doi.org/10.1016/j.biomaterials.2013.09.086] [PMID: 24125773]
[39]
Amann E, Wolff P, Breel E, van Griensven M, Balmayor ER. Hyaluronic acid facilitates chondrogenesis and matrix deposition of human adipose derived mesenchymal stem cells and human chondrocytes co-cultures. Acta Biomater 2017; 52: 130-44.
[http://dx.doi.org/10.1016/j.actbio.2017.01.064] [PMID: 28131943]
[40]
Liu Y, Chan JK, Teoh SH. Review of vascularised bone tissue-engineering strategies with a focus on co-culture systems. J Tissue Eng Regen Med 2015; 9(2): 85-105.
[http://dx.doi.org/10.1002/term.1617] [PMID: 23166000]
[41]
Hong S, Pan Q, Lee LP. Single-cell level co-culture platform for intercellular communication. Integr Biol 2012; 4(4): 374-80.
[http://dx.doi.org/10.1039/c2ib00166g] [PMID: 22434268]
[42]
Paschos NK, Brown WE, Eswaramoorthy R, Hu JC, Athanasiou KA. Advances in tissue engineering through stem cell-based co-culture. J Tissue Eng Regen Med 2015; 9(5): 488-503.
[http://dx.doi.org/10.1002/term.1870] [PMID: 24493315]
[43]
Shi S, Xie J, Zhong J, et al. Effects of low oxygen tension on gene profile of soluble growth factors in co-cultured adipose-derived stromal cells and chondrocytes. Cell Prolif 2016; 49(3): 341-51.
[http://dx.doi.org/10.1111/cpr.12259] [PMID: 27090063]
[44]
Zhang F, Su K, Fang Y, Sandhya S, Wang DA. A mixed co-culture of mesenchymal stem cells and transgenic chondrocytes in alginate hydrogel for cartilage tissue engineering. J Tissue Eng Regen Med 2015; 9(1): 77-84.
[http://dx.doi.org/10.1002/term.1641] [PMID: 23166064]
[45]
Wu L, Leijten JC, Georgi N, Post JN, van Blitterswijk CA, Karperien M. Trophic effects of mesenchymal stem cells increase chondrocyte proliferation and matrix formation. Tissue Eng Part A 2011; 17(9-10): 1425-36.
[http://dx.doi.org/10.1089/ten.tea.2010.0517] [PMID: 21247341]
[46]
Acharya C, Adesida A, Zajac P, et al. Enhanced chondrocyte proliferation and mesenchymal stromal cells chondrogenesis in coculture pellets mediate improved cartilage formation. J Cell Physiol 2012; 227(1): 88-97.
[http://dx.doi.org/10.1002/jcp.22706] [PMID: 22025108]
[47]
Wu L, Leijten J, van Blitterswijk CA, Karperien M. Fibroblast growth factor-1 is a mesenchymal stromal cell-secreted factor stimulating proliferation of osteoarthritic chondrocytes in co-culture. Stem Cells Dev 2013; 22(17): 2356-67.
[http://dx.doi.org/10.1089/scd.2013.0118] [PMID: 23557133]
[48]
Xu L, Wu Y, Xiong Z, Zhou Y, Ye Z, Tan WS. Mesenchymal Stem Cells Reshape and Provoke Proliferation of Articular Chondrocytes by Paracrine Secretion. Sci Rep 2016; 6: 32705.
[http://dx.doi.org/10.1038/srep32705] [PMID: 27596239]
[49]
Nazempour A, Van Wie BJ. Chondrocytes, mesenchymal stem cells, and their combination in articular cartilage regenerative medicine. Ann Biomed Eng 2016; 44(5): 1325-54.
[http://dx.doi.org/10.1007/s10439-016-1575-9] [PMID: 26987846]
[50]
Shi J, Liang J, Guo B, et al. Adipose-derived stem cells cocultured with chondrocytes promote the proliferation of chondrocytes. Stem Cells Int 2017; •••20171709582
[http://dx.doi.org/10.1155/2017/1709582] [PMID: 28133485]
[51]
Hubka KM, Dahlin RL, Meretoja VV, Kasper FK, Mikos AG. Enhancing chondrogenic phenotype for cartilage tissue engineering: monoculture and coculture of articular chondrocytes and mesenchymal stem cells. Tissue Eng Part B Rev 2014; 20(6): 641-54.
[http://dx.doi.org/10.1089/ten.teb.2014.0034] [PMID: 24834484]
[52]
McCorry MC, Puetzer JL, Bonassar LJ. Characterization of mesenchymal stem cells and fibrochondrocytes in three-dimensional co-culture: analysis of cell shape, matrix production, and mechanical performance. Stem Cell Res Ther 2016; 7: 39.
[http://dx.doi.org/10.1186/s13287-016-0301-8] [PMID: 26971202]
[53]
Sabatino MA, Santoro R, Gueven S, et al. Cartilage graft engineering by co-culturing primary human articular chondrocytes with human bone marrow stromal cells. J Tissue Eng Regen Med 2015; 9(12): 1394-403.
[http://dx.doi.org/10.1002/term.1661] [PMID: 23225781]
[54]
Wu L, Prins HJ, Helder MN, van Blitterswijk CA, Karperien M. Trophic effects of mesenchymal stem cells in chondrocyte co-cultures are independent of culture conditions and cell sources. Tissue Eng Part A 2012; 18(15-16): 1542-51.
[http://dx.doi.org/10.1089/ten.tea.2011.0715] [PMID: 22429306]
[55]
Liu Y, Zou R, Wang Z, Wen C, Zhang F, Lin F. Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis. Biochem J 2018; 475(22): 3629-38.
[http://dx.doi.org/10.1042/BCJ20180675] [PMID: 30341166]
[56]
Zahari W, Hashim SN, Yusof MF, et al. Immunomodulatory effect of cytokines in the differentiation of mesenchymal stem cells: A review. Curr Stem Cell Res Ther 2017; 12(3): 197-206.
[http://dx.doi.org/10.2174/1574888X11666160614103404] [PMID: 27306400]
[57]
Fontaine MJ, Shih H, Schäfer R, Pittenger MF. Unraveling the Mesenchymal Stromal Cells’ Paracrine Immunomodulatory Effects. Transfus Med Rev 2016; 30(1): 37-43.
[http://dx.doi.org/10.1016/j.tmrv.2015.11.004] [PMID: 26689863]
[58]
Qing C, Wei-ding C, Wei-min F. Co-culture of chondrocytes and bone marrow mesenchymal stem cells in vitro enhances the expression of cartilaginous extracellular matrix components. Braz J Med Biol Res 2011; 44(4): 303-10.
[http://dx.doi.org/10.1590/S0100-879X2011000400006] [PMID: 21487642]
[59]
Li X, Duan L, Liang Y, Zhu W, Xiong J, Wang D. Human umbilical cord blood-derived mesenchymal stem cells contribute to chondrogenesis in coculture with chondrocytes. BioMed Res Int 2016.20163827057
[http://dx.doi.org/10.1155/2016/3827057] [PMID: 27446948]
[60]
Tang X, Sheng L, Xie F, Zhang Q. Differentiation of bone marrow-derived mesenchymal stem cells into chondrocytes using chondrocyte extract. Mol Med Rep 2012; 6(4): 745-9.
[http://dx.doi.org/10.3892/mmr.2012.996] [PMID: 22825624]
[61]
Aung A, Gupta G, Majid G, Varghese S. Osteoarthritic chondrocyte-secreted morphogens induce chondrogenic differentiation of human mesenchymal stem cells. Arthritis Rheum 2011; 63(1): 148-58.
[http://dx.doi.org/10.1002/art.30086] [PMID: 20954186]
[62]
Zhong L, Huang X, Karperien M, Post JN. The regulatory role of signaling crosstalk in hypertrophy of MSCs and human articular chondrocytes. Int J Mol Sci 2015; 16(8): 19225-47.
[http://dx.doi.org/10.3390/ijms160819225] [PMID: 26287176]
[63]
Nasrabadi D, Rezaeiani S, Eslaminejad MB, Shabani A. Improved protocol for chondrogenic differentiation of bone marrow derived mesenchymal stem cells -effect of PTHrP and FGF-2 on TGFβ1/BMP2-induced chondrocytes hypertrophy. Stem Cell Rev Rep 2018; 14(5): 755-66.
[http://dx.doi.org/10.1007/s12015-018-9816-y] [PMID: 29691795]
[64]
Pleumeekers MM, Nimeskern L, Koevoet JLM, Karperien M, Stok KS, van Osch GJVM. Trophic effects of adipose-tissue-derived and bone-marrow-derived mesenchymal stem cells enhance cartilage generation by chondrocytes in co-culture. PLoS One 2018; 13(2)e0190744
[http://dx.doi.org/10.1371/journal.pone.0190744] [PMID: 29489829]
[65]
Goers L, Freemont P, Polizzi KM. Co-culture systems and technologies: taking synthetic biology to the next level. J R Soc Interface 2014; 11(96)20140065
[http://dx.doi.org/10.1098/rsif.2014.0065] [PMID: 24829281]
[66]
Juhász T, Matta C, Somogyi C, et al. Mechanical loading stimulates chondrogenesis via the PKA/CREB-Sox9 and PP2A pathways in chicken micromass cultures. Cell Signal 2014; 26(3): 468-82.
[http://dx.doi.org/10.1016/j.cellsig.2013.12.001] [PMID: 24333667]
[67]
Khozoee B, Mafi P, Mafi R, Khan WS. Mechanical stimulation protocols of human derived cells in articular cartilage tissue engineering - a systematic review. Curr Stem Cell Res Ther 2017; 12(3): 260-70.
[http://dx.doi.org/10.2174/1574888X11666160614103840] [PMID: 27306401]
[68]
Fahy N, Alini M, Stoddart MJ. Mechanical stimulation of mesenchymal stem cells: Implications for cartilage tissue engineering. J Orthop Res 2018; 36(1): 52-63.
[PMID: 28763118]
[69]
O’Conor CJ, Case N, Guilak F. Mechanical regulation of chondrogenesis. Stem Cell Res Ther 2013; 4(4): 61.
[http://dx.doi.org/10.1186/scrt211] [PMID: 23809493]
[70]
Musumeci G, Loreto C, Imbesi R, et al. Advantages of exercise in rehabilitation, treatment and prevention of altered morphological features in knee osteoarthritis. A narrative review. Histol Histopathol 2014; 29(6): 707-19.
[PMID: 24452819]
[71]
Ford CA, Nowlan NC, Thomopoulos S, Killian ML. Effects of imbalanced muscle loading on hip joint development and maturation. J Orthop Res 2017; 35(5): 1128-36.
[http://dx.doi.org/10.1002/jor.23361] [PMID: 27391299]
[72]
Steinecker-Frohnwieser B, Kaltenegger H, Weigl L, et al. Pharmacological treatment with diacerein combined with mechanical stimulation affects the expression of growth factors in human chondrocytes. Biochem Biophys Rep 2017; 11: 154-60.
[http://dx.doi.org/10.1016/j.bbrep.2017.06.006] [PMID: 28955780]
[73]
Ouyang X, Xie Y, Wang G. Mechanical stimulation promotes the proliferation and the cartilage phenotype of mesenchymal stem cells and chondrocytes co-cultured in vitro. Biomed Pharmacother 2019.117109146
[http://dx.doi.org/10.1016/j.biopha.2019.109146] [PMID: 31387186]
[74]
Szychlinska MA, Stoddart MJ, D’Amora U, Ambrosio L, Alini M, Musumeci G. Mesenchymal stem cell-based cartilage regeneration approach and cell senescence: Can we manipulate cell aging and function? Tissue Eng Part B Rev 2017; 23(6): 529-39.
[http://dx.doi.org/10.1089/ten.teb.2017.0083] [PMID: 28514935]
[75]
Zhong W, Tian K, Zheng X, et al. Mesenchymal stem cell and chondrocyte fates in a multishear microdevice are regulated by Yes-associated protein. Stem Cells Dev 2013; 22(14): 2083-93.
[http://dx.doi.org/10.1089/scd.2012.0685] [PMID: 23442010]
[76]
Hosseini MS, Tafazzoli-Shadpour M, Haghighipour N, Aghdami N, Goodarzi A. The synergistic effects of shear stress and cyclic hydrostatic pressure modulate chondrogenic induction of human mesenchymal stem cells. Int J Artif Organs 2015; 38(10): 557-64.
[http://dx.doi.org/10.5301/ijao.5000433] [PMID: 26541277]
[77]
Bao X, Li Z, Liu H, et al. Stimulation of chondrocytes and chondroinduced mesenchymal stem cells by osteoinduced mesenchymal stem cells under a fluid flow stimulus on an integrated microfluidic device. Mol Med Rep 2018; 17(2): 2277-88.
[PMID: 29207069]
[78]
Yang ZQ, Men YX. [Effect of equiaxial tensile strain in early differentiation of mesenchymal stem cells into cartilage cells Zhongguo Gu Shang 2018; 31(9): 846-52.
[PMID: 30332879]
[79]
Huang CY, Hagar KL, Frost LE, Sun Y, Cheung HS. Effects of cyclic compressive loading on chondrogenesis of rabbit bone-marrow derived mesenchymal stem cells. Stem Cells 2004; 22(3): 313-23.
[http://dx.doi.org/10.1634/stemcells.22-3-313] [PMID: 15153608]
[80]
Guo T, Yu L, Lim CG, et al. Effect of dynamic culture and periodic compression on human mesenchymal stem cell proliferation and chondrogenesis. Ann Biomed Eng 2016; 44(7): 2103-13.
[http://dx.doi.org/10.1007/s10439-015-1510-5] [PMID: 26577256]
[81]
Remya NS, Nair PD. Mechanoresponsiveness of human umbilical cord mesenchymal stem cells in in vitro chondrogenesis-A comparative study with growth factor induction. J Biomed Mater Res A 2016; 104(10): 2554-66.
[http://dx.doi.org/10.1002/jbm.a.35792] [PMID: 27227673]
[82]
Zamanlui S, Amirabad LM, Soleimani M, Faghihi S. Influence of hydrodynamic pressure on chondrogenic differentiation of human bone marrow mesenchymal stem cells cultured in perfusion system. Biologicals 2018; 56: 1-8.
[http://dx.doi.org/10.1016/j.biologicals.2018.04.004] [PMID: 30177432]
[83]
Vining KH, Mooney DJ. Mechanical forces direct stem cell behaviour in development and regeneration. Nat Rev Mol Cell Biol 2017; 18(12): 728-42.
[http://dx.doi.org/10.1038/nrm.2017.108] [PMID: 29115301]
[84]
Jeong JY, Park SH, Shin JW, Kang YG, Han KH, Shin JW. Effects of intermittent hydrostatic pressure magnitude on the chondrogenesis of MSCs without biochemical agents under 3D co-culture. J Mater Sci Mater Med 2012; 23(11): 2773-81.
[http://dx.doi.org/10.1007/s10856-012-4718-z] [PMID: 22802107]
[85]
Chen CH, Kuo CY, Chen JP. Effect of cyclic dynamic compressive loading on chondrocytes and adipose-derived stem cells co-cultured in highly elastic cryogel scaffolds. Int J Mol Sci 2018; 19(2): 370.
[http://dx.doi.org/10.3390/ijms19020370]


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VOLUME: 15
ISSUE: 1
Year: 2020
Published on: 19 March, 2020
Page: [54 - 60]
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DOI: 10.2174/1574888X14666191029104249
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