Title:Distorted Key Theory and its Implication for Drug Development
VOLUME: 17 ISSUE: 4
Author(s):Kuo-Chen Chou*
Affiliation:Gordon Life Science Institute, Boston, MA 02478
Keywords:HIV, SARS, protein cleavage sites, lock and key, induced fit theory, rack mechanism, peptide drugs.
Abstract:During the last three decades or so, many efforts have been made to study the protein cleavage
sites by some disease-causing enzyme, such as HIV (Human Immunodeficiency Virus) protease
and SARS (Severe Acute Respiratory Syndrome) coronavirus main proteinase. It has become increasingly
clear via this mini-review that the motivation driving the aforementioned studies is quite wise,
and that the results acquired through these studies are very rewarding, particularly for developing peptide
drugs.
