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Current Proteomics

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ISSN (Print): 1570-1646
ISSN (Online): 1875-6247

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Mini-Review Article

Distorted Key Theory and its Implication for Drug Development

Author(s): Kuo-Chen Chou*

Volume 17, Issue 4, 2020

Page: [311 - 323] Pages: 13

DOI: 10.2174/1570164617666191025101914

Price: $65

Abstract

During the last three decades or so, many efforts have been made to study the protein cleavage sites by some disease-causing enzyme, such as HIV (Human Immunodeficiency Virus) protease and SARS (Severe Acute Respiratory Syndrome) coronavirus main proteinase. It has become increasingly clear via this mini-review that the motivation driving the aforementioned studies is quite wise, and that the results acquired through these studies are very rewarding, particularly for developing peptide drugs.

Keywords: HIV, SARS, protein cleavage sites, lock and key, induced fit theory, rack mechanism, peptide drugs.

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Graphical Abstract

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