Nanoparticle Delivery Systems for DNA/RNA and their Potential Applications in Nanomedicine

Author(s): Hua Shen, Xiaoyi Huang, Jie Min, Shiguan Le, Qing Wang, Xi Wang, Asli Aybike Dogan, Xiangsheng Liu, Pengfei Zhang, Mohamed S. Draz*, Jian Xiao*

Journal Name: Current Topics in Medicinal Chemistry

Volume 19 , Issue 27 , 2019

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Graphical Abstract:


The rapid development of nanotechnology has a great influence on the fields of biology, physiology, and medicine. Over recent years, nanoparticles have been widely presented as nanocarriers to help the delivery of gene, drugs, and other therapeutic agents with cellular targeting ability. Advances in the understanding of gene delivery and RNA interference (RNAi)-based therapy have brought increasing attention to understanding and tackling complex genetically related diseases, such as cancer, cardiovascular and pulmonary diseases, autoimmune diseases and infections. The combination of nanocarriers and DNA/RNA delivery may potentially improve their safety and therapeutic efficacy. However, there still exist many challenges before this approach can be practiced in the clinic. In this review, we provide a comprehensive summary on the types of nanoparticle systems used as nanocarriers, highlight the current use of nanocarriers in recombinant DNA and RNAi molecules delivery, and the current landscape of gene-based nanomedicine-ranging from diagnosis to therapeutics. Finally, we briefly discuss the biosafety concerns and limitations in the preclinical and clinical development of nanoparticle gene systems.

Keywords: Nanoparticle, RNAi, Recombinant DNA, Gene delivery, Cancer, Cardiovascular diseases, Infectious diseases.

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Year: 2019
Published on: 17 December, 2019
Page: [2507 - 2523]
Pages: 17
DOI: 10.2174/1568026619666191024170212
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