The critical link between cancer and inflammation has been known for many
years. This complex network was further complexed by revealing the association of the
matrix metalloproteinase family members with inflammatory cytokines, which were previously
known to be responsible for the development of metastasis. This article summarizes
the current studies which evaluate the relationship between cancer and inflammatory microenvironment
as well as the roles of MMPs on invasion and metastasis together.
Keywords: Cancer, cytokine, inflammation, matrix metalloproteinase, TIMP, inhibitors.
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