Recent Advances and Future Perspectives in Pharmaceutical Analysis

Author(s): Nurgul K. Bakirhan, Sibel A. Ozkan*

Journal Name: Current Pharmaceutical Analysis

Volume 16 , Issue 1 , 2020

Become EABM
Become Reviewer
Call for Editor


The role of the analytical methods and their validations has been important in quantification of drugs from their dosage forms or biological samples in recent years. Development of analytical methodscoupled with each other, is useful for the investigation of behavior of drugs or metabolites or impurities, and is also a useful tool for sensitive detections. The recent roles of spectroscopy, chromatography, titrimetry, electrochemistry and capillary electrophoresis have been explained here.

Keywords: Pharmaceuticals, drug analysis, analytical methods, drug development, Raman spectroscopy, LC-MS/MS.

Xu, Y.; Ye, Z.; Li, C.; McCabe, H.; Kelly, J.; Bell, S.E.J. Pressing solids directly into sheets of plasmonic nanojunctions enables solvent-free surface-enhanced raman spectroscopy. Appl. Mater. Today, 2018, 13, 352-358.
Truver, M.T.; Swortwood, M.J. Quantitative analysis of novel synthetic opioids, morphine and buprenorphine in oral fluid by LC-MS-MS. J. Anal. Toxicol., 2018, 42, 554-561.
Yenugu, V.M.R.; Ambavaram, V.B.R.; Moniruzzaman, M.; Madhavi, G.A. Simple, Sensitive, and Straightforward LC-MS approach for rapid analysis of three potential genotoxic impurities in rabeprazole formulations. J. Sep. Sci., 2018, 41, 3966-3973.
Schug, K.; McNair, H.M. Adduct formation in electrospray ionization. part 1: common acidic pharmaceuticals. J. Sep. Sci., 2002, 25, 759-766.
Schug, K.; McNair, H.M. Adduct formation in electrospray ionization mass spectrometry: II. benzoic acid derivatives. J. Chromatogr. A, 2003, 985, 531-539.
Mendes, L.F.; Souza e Silva, Â.R.; Bacil, R.P.; Serrano, S.H.P.; Angnes, L.; Paixão, T.R.L.C.; de Araujo, W.R. Forensic electrochemistry: electrochemical study and quantification of xylazine in pharmaceutical and urine samples. Electrochim. Acta, 2019, 295, 726-734.
Abdollahi-Aghdam, A.; Majidi, M.R.; Omidi, Y. Microfluidic paper-based analytical devices (μpads) for fast and ultrasensitive sensing of biomarkers and monitoring of diseases. Bioimpacts, 2018, 8, 237-240.
Moghaddam, H.M.; Malakootian, M.; Electrochemistry, B. Differential pulse voltammetric determination of levodopa in pharmaceutical and biological samples using nio/graphene oxide nanocomposite modified graphite screen printed electrode. Analyt. Bioanal. Electrochem., 2018, 10(5), 520-530.
de Souza, M.J.M.; Kogawa, A.C.; Salgado, H.R.N. New and miniaturized method for analysis of enrofloxacin in palatable tablets. Spectrochimica. Acta., 2019, 209, 1-7.
Krait, S.; Scriba, G.K.E. Quality by design-assisted development of a capillary electrophoresis method for the chiral purity determination of dexmedetomidine. Electrophoresis, 2018, 39, 2575-2580.
Bonvin, G.; Schappler, J.; Rudaz, S. Non-aqueous capillary electrophoresis for the analysis of acidic compounds using negative electrospray ionization mass spectrometry. J. Chromatogr. A, 2014, 1323, 163-173.
Lima, A.B.; de Oliveira, F.M.; Guedes, T. de J.; Sousa, R.M.F.; Munoz, R.A.A.; dos Santos, W.T.P. Altered Electrochemistry of oxcarbazepine on cathodically treated boron-doped diamond electrode: selective detection by pulsed amperometric detection coupled to flow-injection analysis. Electrochim. Acta, 2018, 260, 564-570.
Smajdor, J.; Piech, R.; Ławrywianiec, M.; Paczosa-Bator, B. Glassy carbon electrode modified with carbon black for sensitive estradiol determination by means of voltammetry and flow injection analysis with amperometric detection. Anal. Biochem., 2018, 544, 7-12.
Rahman, N.; Anwar, N.; Kashif, M. Application of π-Acceptors to the spectrophotometric determination of lisinopril in commercial dosage forms. Farmaco, 2005, 60, 605-611.

promotion: free to download

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2020
Published on: 20 December, 2019
Page: [2 - 4]
Pages: 3
DOI: 10.2174/157341291601191023100143

Article Metrics

PDF: 31