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Current Pediatric Reviews

Editor-in-Chief

ISSN (Print): 1573-3963
ISSN (Online): 1875-6336

Review Article

Eosinophilic Gastrointestinal Diseases in Children: A Practical Review

Author(s): Amelia Licari, Martina Votto, Enza D’Auria, Riccardo Castagnoli, Silvia Maria Elena Caimmi and Gian Luigi Marseglia*

Volume 16, Issue 2, 2020

Page: [106 - 114] Pages: 9

DOI: 10.2174/1573396315666191022154432

Abstract

Primary eosinophilic gastrointestinal diseases (EGIDs) represent a heterogeneous group of disorders characterized by eosinophilic inflammation in the absence of known causes for eosinophilia, selectively affecting different segments of the gastrointestinal tract. While pediatric eosinophilic esophagitis (EoE) is a well-defined disease with established guidelines, Eosinophilic Gastritis (EoG), Eosinophilic Gastroenteritis (EoGE) and Eosinophilic Colitis (EoC) remain a clinical enigma with evidence based on limited anecdotal case reports. Large cross-sectional studies in the US defined a prevalence of EoG and EoGE ranging from 1,5 to 6,4/100.000 and from 2,7 to 8,3/100.000 subjects respectively, while the prevalence of EoC ranges from 1,7 to 3,5/100.000 subjects. Regarding the pathogenesis, it is hypothesized that EGIDs result from the interplay between genetic predisposition, intestinal dysbiosis and environmental triggers. Clinically, EGIDs might present with different and nonspecific gastrointestinal symptoms depending on the involved intestinal tract and the extension of eosinophilic inflammatory infiltrate. The diagnosis of EGIDs requires: 1. recurrent gastrointestinal symptoms, 2. increased eosinophils for high power field in biopsy specimens, 3. absence of secondary causes of gastrointestinal eosinophilia. No validated guidelines are available on the clinical management of patients with EGIDs. Evidence from case reports and small uncontrolled case series suggests the use of dietary and corticosteroids as the first-line treatments. Considering the clinical follow-up of EGIDs, three different patterns of disease course are identified: single flare, recurring course-disease and chronic course-disease. This review will focus on pediatric EGIDs distal to esophagus, including Eosinophilic Gastritis (EoG), Eosinophilic Gastroenteritis (EoGE) and Eosinophilic Colitis (EoC).

Keywords: Eosinophils, eosinophilic gastrointestinal diseases, eosinophilic gastroenteritis, eosinophilic colitis, food allergy, endoscopy, diet, corticosteroids.

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[1]
Rothenberg ME. Eosinophilic gastrointestinal disorders (EGID). J Allergy Clin Immunol 2004; 113(1): 11-28..
[http://dx.doi.org/10.1016/j.jaci.2003.10.047] [PMID: 14713902]
[2]
Klein NC, Hargrove RL, Sleisenger MH, Jeffries GH. Eosinophilic gastroenteritis Medicine (Baltimore) 1970; 49(4): 299-319..
[http://dx.doi.org/10.1097/00005792-197007000-00003] [PMID: 5426746]
[3]
D’Auria E, Abrahams M, Zuccotti GV, Venter C. Personalized Nutrition Approach in Food Allergy: Is It Prime Time Yet? Nutrients 2019; 11(2): E359..
[http://dx.doi.org/10.3390/nu11020359] [PMID: 30744105]
[4]
Kaijser R. Zur Kenntnis der allergischen affektionen des verdauungskanals vom standpunkt des chirurgen aus. Archiv für Klinische Chirurgie 1936; 188: 35-64.
[5]
Zhang L, Duan L, Ding S, et al. Eosinophilic gastroenteritis: clinical manifestations and morphological characteristics, a retrospective study of 42 patients Scand J Gastroenterol 2011; 46(9): 1074-80..
[http://dx.doi.org/10.3109/00365521.2011.579998] [PMID: 21623674]
[6]
Mansoor E, Cooper GS. The 2010-2015 prevalence of eosinophilic esophagitis in the USA: A population-based study. Dig Dis Sci 2016; 61(10): 2928-34..
[http://dx.doi.org/10.1007/s10620-016-4204-4] [PMID: 27250980]
[7]
Jensen ET, Martin CF, Kappelman MD, Dellon ES. Prevalence of eosinophilic gastritis, gastroenteritis, and colitis: estimates from a national administrative database. J Pediatr Gastroenterol Nutr 2016; 62(1): 36-42..
[http://dx.doi.org/10.1097/MPG.0000000000000865] [PMID: 25988554]
[8]
Mansoor E, Saleh MA, Cooper GS. Prevalence of eosinophilic gastroenteritis and colitis in a population-based study, From 2012 to 2017. Clin Gastroenterol Hepatol 2017; 15(11): 1733-41..
[http://dx.doi.org/10.1016/j.cgh.2017.05.050] [PMID: 28603057]
[9]
Pineton de Chambrun G, Dufour G, Tassy B, et al. Diagnosis, natural history and treatment of eosinophilic enteritis: A review Curr Gastroenterol Rep 2018; 20(8): 37..
[http://dx.doi.org/10.1007/s11894-018-0645-6] [PMID: 29968127]
[10]
Spergel JM, Book WM, Mays E, et al. Variation in prevalence, diagnostic criteria, and initial management options for eosinophilic gastrointestinal diseases in the United States. J Pediatr Gastroenterol Nutr 2011; 52(3): 300-6..
[http://dx.doi.org/10.1097/MPG.0b013e3181eb5a9f] [PMID: 21057327]
[11]
Lucendo AJ. Immunopathological mechanisms of eosinophilic oesophagitis Allergol Immunopathol (Madr) 2008; 36(4): 215-27..
[http://dx.doi.org/10.1016/S0301-0546(08)72553-9] [PMID: 18928689]
[12]
Talley NJ, Kephart GM, McGovern TW, Carpenter HA, Gleich GJ. Deposition of eosinophil granule major basic protein in eosinophilic gastroenteritis and celiac disease Gastroenterology 1992; 103(1): 137-45..
[http://dx.doi.org/10.1016/0016-5085(92)91106-E] [PMID: 1612323]
[13]
Hogan SP, Rothenberg ME, Forbes E, Smart VE, Matthaei KI, Foster PS. Chemokines in eosinophil-associated gastrointestinal disorders Curr Allergy Asthma Rep 2004; 4(1): 74-82..
[http://dx.doi.org/10.1007/s11882-004-0047-8] [PMID: 14680626]
[14]
Rothenberg ME, Hogan SP. The eosinophil Annu Rev Immunol 2006; 24: 147-74..
[http://dx.doi.org/10.1146/annurev.immunol.24.021605.090720] [PMID: 16551246]
[15]
Kagalwalla AF, Sentongo TA, Ritz S, et al. Effect of six-food elimination diet on clinical and histologic outcomes in eosinophilic esophagitis. Clin Gastroenterol Hepatol 2006; 4(9): 1097-102..
[http://dx.doi.org/10.1016/j.cgh.2006.05.026] [PMID: 16860614]
[16]
Pajno GB, Castagnoli R, Muraro A, et al. Allergen immunotherapy for IgE-mediated food allergy: There is a measure in everything to a proper proportion of therapy. Pediatr Allergy Immunol 2019; 30(4): 415-22..
[http://dx.doi.org/10.1111/pai.13042] [PMID: 30770574]
[17]
D’Auria E, Salvatore S, Pozzi E, et al. Cow’s Milk Allergy: Immunomodulation by Dietary Intervention. Nutrients 2019; 11(6): E1399..
[http://dx.doi.org/10.3390/nu11061399] [PMID: 31234330]
[18]
Lecouffe-Desprets M, Groh M, Bour B, Le Jeunne C, Puéchal X. Eosinophilic gastrointestinal disorders associated with autoimmune connective tissue disease Joint Bone Spine 2016; 83(5): 479-84..
[http://dx.doi.org/10.1016/j.jbspin.2015.11.006] [PMID: 26709253]
[19]
Licari A, Castagnoli R, Marseglia GL. Eosinophilic esophagitis after congenital diaphragmatic hernia Ital J Pediatr 2016; 42(1): 96..
[http://dx.doi.org/10.1186/s13052-016-0307-y] [PMID: 27821174]
[20]
Keely S, Walker MM, Marks E, Talley NJ. Immune dysregulation in the functional gastrointestinal disorders Eur J Clin Invest 2015; 45(12): 1350-9..
[http://dx.doi.org/10.1111/eci.12548] [PMID: 26444549]
[21]
Walker MM. Inflammation, genetics, dysbiosis, and the environment: New paradigms for diagnosis in complex chronic gut syndromes. J Clin Gastroenterol 2016; 50(Suppl. 1): S4-5..
[http://dx.doi.org/10.1097/MCG.0000000000000613] [PMID: 27622361]
[22]
Talley NJ, Shorter RG, Phillips SF, Zinsmeister AR. Eosinophilic gastroenteritis: a clinicopathological study of patients with disease of the mucosa, muscle layer, and subserosal tissues Gut 1990; 31(1): 54-8..
[http://dx.doi.org/10.1136/gut.31.1.54] [PMID: 2318432]
[23]
Pineton de Chambrun G, Gonzalez F, Canva JY, et al. Natural history of eosinophilic gastroenteritis Clin Gastroenterol Hepatol 2011; 9(11): 950-956.e1..
[http://dx.doi.org/10.1016/j.cgh.2011.07.017] [PMID: 21806952]
[24]
Uppal V, Kreiger P, Kutsch E. Eosinophilic gastroenteritis and colitis: a comprehensive review Clin Rev Allergy Immunol 2016;50(2): 175-88..
[http://dx.doi.org/10.1007/s12016-015-8489-4] [PMID: 26054822]
[25]
Lucendo AJ. Disease associations in eosinophilic oesophagitis and oesophageal eosinophilia Best Pract Res Clin Gastroenterol 2015; 29(5): 759-69..
[http://dx.doi.org/10.1016/j.bpg.2015.06.010] [PMID: 26552775]
[26]
Yun MY, Cho YU, Park IS, et al. Eosinophilic gastroenteritis presenting as small bowel obstruction: a case report and review of the literature World J Gastroenterol 2007; 13(11): 1758-60..
[http://dx.doi.org/10.3748/wjg.v13.i11.1758] [PMID: 17461485]
[27]
Baek MS, Mok YM, Han WC, Kim YS. A patient with eosinophilic gastroenteritis presenting with acute pancreatitis and ascites Gut Liver 2014; 8(2): 224-7..
[http://dx.doi.org/10.5009/gnl.2014.8.2.224] [PMID: 24672666]
[28]
Issa H, Bseiso B, Al-Salem AH. Eosinophilic enteritis presenting as a perforated duodenal ulcer Endoscopy 2011; 43(Suppl 2 UCTN): E358-9..
[http://dx.doi.org/10.1055/s-0030-1256526] [PMID: 22068643]
[29]
Siaw EK, Sayed K, Jackson RJ. osinophilic gastroenteritis presenting as acute gastric perforation. J Pediatr Gastroenterol Nutr 2006; 43(5): 691-4..
[http://dx.doi.org/10.1097/01.mpg.0000239996.66011.89] [PMID: 17130750]
[30]
Zhang M, Li Y. Eosinophilic gastroenteritis: A state-of-the-art review. J Gastroenterol Hepatol 2017; 32(1): 64-72..
[http://dx.doi.org/10.1111/jgh.13463] [PMID: 27253425]
[31]
Cianferoni A, Spergel JM. Eosinophilic esophagitis and gastroenteritis Curr Allergy Asthma Rep 2015; 15(9): 58..
[http://dx.doi.org/10.1007/s11882-015-0558-5] [PMID: 26233430]
[32]
Ko HM, Morotti RA, Yershov O, Chehade M. Eosinophilic gastritis in children: clinicopathological correlation, disease course, and response to therapy Am J Gastroenterol 2014; 109(8): 1277-85..
[http://dx.doi.org/10.1038/ajg.2014.166] [PMID: 24957155]
[33]
D’Auria E, Mameli C, Piras C, et al. Precision medicine in cow’s milk allergy: proteomics perspectives from allergens to patients. J Proteomics 2018; 188: 173-80..
[http://dx.doi.org/10.1016/j.jprot.2018.01.018] [PMID: 29408543]
[34]
Bischoff SC, Mayer J, Nguyen QT, Stolte M, Manns MP. Immunnohistological assessment of intestinal eosinophil activation in patients with eosinophilic gastroenteritis and inflammatory bowel disease Am J Gastroenterol 1999; 94(12): 3521-9..
[http://dx.doi.org/10.1111/j.1572-0241.1999.01641.x] [PMID: 10606314]
[35]
Turner KO, Sinkre RA, Neumann WL, Genta RM. Primary Colonic Eosinophilia and Eosinophilic Colitis in Adults Am J Surg Pathol 2017; 41(2): 225-33..
[http://dx.doi.org/10.1097/PAS.0000000000000760] [PMID: 27792062]
[36]
Anuradha C, Mittal R, Yacob M, Manipadam MT, Kurian S, Eapen A. Eosinophilic disorders of the gastrointestinal tract: imaging features Diagn Interv Radiol 2012; 18(2): 183-8..
[PMID: 21948696]
[37]
Khan S, Orenstein SR. Eosinophilic gastroenteritis Gastroenterol Clin North Am 2008; 37(2): 333-348, v..
[http://dx.doi.org/10.1016/j.gtc.2008.02.003] [PMID: 18499023]
[38]
Brandon JL, Schroeder S, Furuta GT, Capocelli K, Masterson JC, Fenton LZ. CT imaging features of eosinophilic colitis in children Pediatr Radiol 2013; 43(6): 697-702..
[http://dx.doi.org/10.1007/s00247-012-2615-8] [PMID: 23361493]
[39]
Lowichik A, Weinberg AG. A quantitative evaluation of mucosal eosinophils in the pediatric gastrointestinal tract Mod Pathol 1996;9(2): 110-4..
[PMID: 8657715]
[40]
DeBrosse CW, Case JW, Putnam PE, Collins MH, Rothenberg ME. Quantity and distribution of eosinophils in the gastrointestinal tract of children Pediatr Dev Pathol 2006; 9(3): 210-8..
[http://dx.doi.org/10.2350/11-05-0130.1] [PMID: 16944979]
[41]
Kiss Z, Tél B, Farkas N, et al. Eosinophil counts in the small intestine and colon of children without apparent gastrointestinal disease: a meta-analysis. J Pediatr Gastroenterol Nutr 2018; 67(1): 6-12..
[http://dx.doi.org/10.1097/MPG.0000000000001904] [PMID: 29394213]
[42]
Lwin T, Melton SD, Genta RM. Eosinophilic gastritis: histopathological characterization and quantification of the normal gastric eosinophil content Mod Pathol 2011; 24(4): 556-63..
[http://dx.doi.org/10.1038/modpathol.2010.221] [PMID: 21169993]
[43]
Egan M, Furuta GT. Eosinophilic gastrointestinal diseases beyond eosinophilic esophagitis Ann Allergy Asthma Immunol 2018;121(2): 162-7..
[http://dx.doi.org/10.1016/j.anai.2018.06.013] [PMID: 29940308]
[44]
Collins MH. Histopathology associated with eosinophilic gastrointestinal diseases Immunol Allergy Clin North Am 2009; 29(1):109-117, x-xi..
[http://dx.doi.org/10.1016/j.iac.2008.10.005] [PMID: 19141346]
[45]
Walker MM, Talley NJ, Inganäs L, et al. Colonic spirochetosis is associated with colonic eosinophilia and irritable bowel syndrome in a general population in Sweden Hum Pathol 2015; 46(2): 277-83..
[http://dx.doi.org/10.1016/j.humpath.2014.10.026] [PMID: 25540866]
[46]
Walker MM, Potter M, Talley NJ. Eosinophilic gastroenteritis and other eosinophilic gut diseases distal to the oesophagus Lancet Gastroenterol Hepatol 2018; 3(4): 271-80..
[http://dx.doi.org/10.1016/S2468-1253(18)30005-0] [PMID: 29533199]
[47]
Walker MM, Potter MD, Talley NJ. Eosinophilic colitis and colonic eosinophilia Curr Opin Gastroenterol 2019; 35(1): 42-50..
[http://dx.doi.org/10.1097/MOG.0000000000000492] [PMID: 30480590]
[48]
Papadopoulos AA, Tzathas C, Polymeros D, Ladas SD. Symptomatic eosinophilic gastritis cured with Helicobacter pylori eradication Gut 2005; 54(12): 1822..
[http://dx.doi.org/10.1136/gut.2005.075077] [PMID: 16284301]
[49]
Schwab D, Müller S, Aigner T, et al. Functional and morphologic characterization of eosinophils in the lower intestinal mucosa of patients with food allergy Am J Gastroenterol 2003; 98(7): 1525-34..
[http://dx.doi.org/10.1111/j.1572-0241.2003.07484.x] [PMID: 12873574]
[50]
Brown IS, Smith J, Rosty C. Gastrointestinal pathology in celiac disease: a case series of 150 consecutive newly diagnosed patients Am J Clin Pathol 2012; 138(1): 42-9..
[http://dx.doi.org/10.1309/AJCPE89ZPVJTSPWL] [PMID: 22706856]
[51]
Carvalho AT, Elia CC, de Souza HS, et al. .Immunohistochemical study of intestinal eosinophils in inflammatory bowel disease. J Clin Gastroenterol 2003; 36(2): 120-5..
[http://dx.doi.org/10.1097/00004836-200302000-00006] [PMID: 12544193]
[52]
Conner JR, Kirsch R. The pathology and causes of tissue eosinophilia in the gastrointestinal tract Histopathology 2017; 71(2): 177-99..
[http://dx.doi.org/10.1111/his.13228] [PMID: 28370248]
[53]
Talley NJ, Walker MM, Aro P, et al. Non-ulcer dyspepsia and duodenal eosinophilia: an adult endoscopic population-based case-control study Clin Gastroenterol Hepatol 2007; 5(10): 1175-83..
[http://dx.doi.org/10.1016/j.cgh.2007.05.015] [PMID: 17686660]
[54]
Klion A. Hypereosinophilic syndrome: current approach to diagnosis and treatment Annu Rev Med 2009; 60: 293-306..
[http://dx.doi.org/10.1146/annurev.med.60.062107.090340] [PMID: 19630574]
[55]
Lucendo AJ, Molina-Infante J, Arias Á, et al. Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults. United European Gastroenterol J 2017; 5(3): 335-58..
[http://dx.doi.org/10.1177/2050640616689525] [PMID: 28507746]
[56]
Munoz-Persy M, Lucendo AJ. Treatment of eosinophilic esophagitis in the pediatric patient: an evidence-based approach Eur J Pediatr 2018; 177(5): 649-63..
[http://dx.doi.org/10.1007/s00431-018-3129-7] [PMID: 29549437]
[57]
Lucendo AJ, Serrano-Montalbán B, Arias Á, Redondo O, Tenias JM. Efficacy of Dietary Treatment for Inducing Disease Remission in Eosinophilic Gastroenteritis. J Pediatr Gastroenterol Nutr 2015; 61(1): 56-64.
[PMID: 25699593]
[58]
Chehade M, Sicherer SH, Magid MS, Rosenberg HK, Morotti RA. Multiple exudative ulcers and pseudopolyps in allergic eosinophilic gastroenteritis that responded to dietary therapy. J Pediatr Gastroenterol Nutr 2007; 45(3): 354-7.
[http://dx.doi.org/10.1097/MPG.0b013e31803219d5] [PMID: 17873749]
[59]
Foroughi S, Prussin C. Clinical management of eosinophilic gastrointestinal disordersCurr Allergy Asthma Rep 2005; 5(4): 259-61.
[http://dx.doi.org/10.1007/s11882-005-0062-4] [PMID: 15967064]
[60]
Lee J, Dierkhising R, Wu TT, Alexander J, Weiler C. Eosinophilic gastrointestinal disorders (EGID) with peripheral eosinophilia: a retrospective review at Mayo Clinic. Dig Dis Sci 2011; 56(11): 3254-61..
[http://dx.doi.org/10.1007/s10620-011-1754-3] [PMID: 21655949]
[61]
Chen MJ, Chu CH, Lin SC, Shih SC, Wang TE. Eosinophilic gastroenteritis: clinical experience with 15 patients World J Gastroenterol 2003; 9(12): 2813-6..
[http://dx.doi.org/10.3748/wjg.v9.i12.2813] [PMID: 14669340]
[62]
Abou Rached A, El Hajj W. Eosinophilic gastroenteritis: Approach to diagnosis and management. World J Gastrointest Pharmacol Ther 2016; 7(4): 513-23..
[http://dx.doi.org/10.4292/wjgpt.v7.i4.513] [PMID: 27867684]
[63]
Iborra M, Alvarez-Sotomayor D, Nos P. Long-term safety and efficacy of budesonide in the treatment of ulcerative colitis Clin Exp Gastroenterol 2014; 7: 39-46..
[PMID: 24523594]
[64]
Tan AC, Kruimel JW, Naber TH. Eosinophilic gastroenteritis treated with non-enteric-coated budesonide tablets Eur J Gastroenterol Hepatol 2001; 13(4): 425-7..
[http://dx.doi.org/10.1097/00042737-200104000-00021] [PMID: 11338074]
[65]
Siewert E, Lammert F, Koppitz P, Schmidt T, Matern S. Eosinophilic gastroenteritis with severe protein-losing enteropathy: successful treatment with budesonide Dig Liver Dis 2006; 38(1): 55-9..
[http://dx.doi.org/10.1016/j.dld.2005.06.013] [PMID: 16326154]
[66]
Gupta N, Aggarwal A, Gupta R, Sule S, Wolf DC. The management of eosinophilic gastroenteritis Scand J Gastroenterol 2015; 50(11): 1309-14..
[http://dx.doi.org/10.3109/00365521.2015.1049655] [PMID: 26027839]
[67]
Ishido K, Tanabe S, Higuchi K, et al. Eosinophilic gastroenteritis associated with giant folds Dig Endosc 2010; 22(4): 312-5..
[http://dx.doi.org/10.1111/j.1443-1661.2010.01012.x] [PMID: 21175485]
[68]
Melamed I, Feanny SJ, Sherman PM, Roifman CM. Benefit of ketotifen in patients with eosinophilic gastroenteritis Am J Med 1991; 90(3): 310-4..
[http://dx.doi.org/10.1016/0002-9343(91)80010-J] [PMID: 2003512]
[69]
Khan S, Orenstein SR. Eosinophilic gastroenteritis: epidemiology, diagnosis and management Paediatr Drugs 2002; 4(9): 563-70..
[http://dx.doi.org/10.2165/00128072-200204090-00002] [PMID: 12175271]
[70]
Schwartz DA, Pardi DS, Murray JA. Use of montelukast as steroid-sparing agent for recurrent eosinophilic gastroenteritis Dig Dis Sci 2001; 46(8): 1787-90..
[http://dx.doi.org/10.1023/A:1010682310928] [PMID: 11508684]
[71]
Friesen CA, Kearns GL, Andre L, Neustrom M, Roberts CC, Abdel-Rahman SM. Clinical efficacy and pharmacokinetics of montelukast in dyspeptic children with duodenal eosinophilia. J Pediatr Gastroenterol Nutr 2004; 38(3): 343-51..
[http://dx.doi.org/10.1097/00005176-200403000-00021] [PMID: 15076638]
[72]
Daikh BE, Ryan CK, Schwartz RH. Montelukast reduces peripheral blood eosinophilia but not tissue eosinophilia or symptoms in a patient with eosinophilic gastroenteritis and esophageal stricture Ann Allergy Asthma Immunol 2003; 90(1): 23-7..
[http://dx.doi.org/10.1016/S1081-1206(10)63609-5] [PMID: 12546333]
[73]
Wechsler ME, Fulkerson PC, Bochner BS, et al. Novel targeted therapies for eosinophilic disorders. J Allergy Clin Immunol 2012; 130(3): 563-71.
[http://dx.doi.org/10.1016/j.jaci.2012.07.027] [PMID: 22935585]
[74]
Licari A, Castagnoli R, Brambilla I, et al. New approaches for identifying and testing potential new anti-asthma agents Expert Opin Drug Discov 2018; 13(1): 51-63..
[http://dx.doi.org/10.1080/17460441.2018.1396315] [PMID: 29077521]
[75]
Straumann A, Conus S, Grzonka P, et al. Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebo-controlled, double-blind trial. Gut 2010; 59(1): 21-30..
[http://dx.doi.org/10.1136/gut.2009.178558] [PMID: 19828470]
[76]
Kim YJ, Prussin C, Martin B, et al. Rebound eosinophilia after treatment of hypereosinophilic syndrome and eosinophilic gastroenteritis with monoclonal anti-IL-5 antibody SCH55700. J Allergy Clin Immunol 2004; 114(6): 1449-55..
[http://dx.doi.org/10.1016/j.jaci.2004.08.027] [PMID: 15577851]
[77]
Licari A, Marseglia A, Caimmi S, et al. Omalizumab in childrenPaediatr Drugs 2014; 16(6): 491-502..
[http://dx.doi.org/10.1007/s40272-014-0107-z] [PMID: 25404353]
[78]
Foroughi S, Foster B, Kim N, et al. Anti-IgE treatment of eosinophil- associated gastrointestinal disorders. J Allergy Clin Immunol 2007; 120(3): 594-601..
[http://dx.doi.org/10.1016/j.jaci.2007.06.015] [PMID: 17765756]
[79]
Alfadda AA, Shaffer EA, Urbanski SJ, Storr MA. Eosinophilic colitis is a sporadic self-limited disease of middle-aged people: a population-based study Colorectal Dis 2014; 16(2): 123-9.
[http://dx.doi.org/10.1111/codi.12464] [PMID: 24138295]
[80]
Redondo-Cerezo E, Cabello MJ, González Y, Gómez M, García-Montero M, de Teresa J. Eosinophilic gastroenteritis: our recent experience: one-year experience of atypical onset of an uncommon disease Scand J Gastroenterol 2001; 36(12): 1358-60.
[http://dx.doi.org/10.1080/003655201317097254] [PMID: 11761030]
[81]
Straumann A, Bussmann C, Conus S, Beglinger C, Simon HU. Anti-TNF-alpha (infliximab) therapy for severe adult eosinophilic esophagitis. J Allergy Clin Immunol 2008; 122(2): 425-7..
[http://dx.doi.org/10.1016/j.jaci.2008.06.012] [PMID: 18678345]
[82]
Turner D, Wolters VM, Russell RK, et al. Anti-TNF, infliximab,and adalimumab can be effective in eosinophilic bowel disease. J Pediatr Gastroenterol Nutr 2013; 56(5): 492-7..
[http://dx.doi.org/10.1097/MPG.0b013e3182801e60] [PMID: 23221994]
[83]
Song DJ, Shim MH, Lee N, Yoo Y, Choung JT. CCR3 Monoclonal antibody inhibits eosinophilic inflammation and mucosal injury in a mouse model of eosinophilic gastroenteritisAllergy Asthma Immunol Res 2017; 9(4): 360-7.
[http://dx.doi.org/10.4168/aair.2017.9.4.360] [PMID: 28497923]
[84]
Straumann A, Hoesli S, Bussmann Ch, et al. Anti-eosinophil activity and clinical efficacy of the CRTH2 antagonist OC000459 in eosinophilic esophagitis Allergy 2013; 68(3): 375-85..
[http://dx.doi.org/10.1111/all.12096] [PMID: 23379537]
[85]
Vindigni SM, Surawicz CM. Fecal Microbiota Transplantation Gastroenterol Clin North Am 2017; 46(1): 171-85..
[http://dx.doi.org/10.1016/j.gtc.2016.09.012] [PMID: 28164849]
[86]
Dai YX, Shi CB, Cui BT, Wang M, Ji GZ, Zhang FM. Fecal microbiota transplantation and prednisone for severe eosinophilic gastroenteritis. World J Gastroenterol 2014; 20(43): 16368-71.
[http://dx.doi.org/10.3748/wjg.v20.i43.16368] [PMID: 25473198]

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