Aims and Objective: In this work, pyran derivatives were synthesized via a multicomponent
reaction of ninhydrin, α-haloketones, dialkyl acetylenedicarboxylate, and triphenylphosphine in the
presence of iron oxide magnetic nanoparticles (Fe3O4-MNPs) as efficient nanocatalyst in ethanol at
Materials and Methods: The biosynthesis of Fe3O4-MNPs was performed by Clover Leaf water
extract. In addition, antioxidant activity was examined for the prepared compounds employing
DPPH radical scavenging and ferric reduction activity potential (FRAP) experiment and comparing
results with synthetic antioxidants (TBHQ and BHT).
Results: Compound 5b showed excellent radical trapping activity and good reducing activity
relative to standards (BHT and TBHQ).
Conclusion: Some advantages of this procedure are: the workup of reaction is easy and the
products can be separated easily by filtration. Fe3O4-MNPs display a good improvement in the
yield of the product and showed significant reusable activity.