Login Register Cart 0
Generic placeholder image

Anti-Infective Agents

Editor-in-Chief

ISSN (Print): 2211-3525
ISSN (Online): 2211-3533

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Studies on X-Ray Diffraction, Thermogravimetric Stability, Antibacterial- Antifungal Activity of Fe(II), Ni(II), Cu(II) Metal Chloroquine Complexes Against Bacterial Strains and Fungal Spore

Author(s): Mukesh Shankarrao Kadam*, Sachin Atmaram Khiste, Satish Ashruba Dake and Bhimrao Chintamanrao Khade*

Volume 18, Issue 4, 2020

Page: [339 - 351] Pages: 13

DOI: 10.2174/2211352517666191021090630

Abstract

Introduction: Synthesis of new coordination complexes has gained a great interest of the inorganic chemists as well as researchers.

Methods: A literature survey has revealed that main group elements as well as transition metals with ligand like Schiff’s base and many drug have the ability to form a coordinate bond. 3d-series of metal complex with chloroquine as a ligand was synthesized (ML2) stoichiometrically and characterized by conductivity, melting point, UV-spectra, TGA and X-ray analysis of coordination complexes and anti-microbial activity.

Results: The synthesized metal complex was evaluated for in vitro antibacterial and antifungal activity against the bacterial strains such as Plasmodium falciparum, Pseudomonas aeruginosa, E. coli, Streptococcus, Bacillus, Staphylococcus aureus and Aspergillus niger.

Conclusion: The metal complex shows very potential antibacterial as well as antifungal activity like a commercial drug. Inorganic chemistry gives us good opportunities to use metal complexes as Pharmacological agents.

Keywords: Antimicrobial activity, coordination complexes, chloroquine, conductivity, metal complex, ligand.

Graphical Abstract

[1]
Shrivastav, A.; Singh, N.K.; Srivastava, G. Synthesis, characterization and antitumor studies of transition metal complexes of o-hydroxydithiobenzoate. Bioorg. Med. Chem., 2002, 10(8), 2693-2704.
[http://dx.doi.org/10.1016/S0968-0896(02)00087-1] [PMID: 12057658]
[2]
Mishra, L.; Said, M.K.; Itokawa, H.; Takeya, K. Antitumor and antimicrobial activities of Fe(II)/Fe(III) complexes derived from some heterocyclic compounds. Bioorg. Med. Chem., 1995, 3(9), 1241-1245.
[http://dx.doi.org/10.1016/0968-0896(95)00095-X] [PMID: 8564416]
[3]
Henderson, D.K. Managing methicillin-resistant staphylococci: a paradigm for preventing nosocomial transmission of resistant organisms. Am. J. Infect. Control, 2006, 34(5)(Suppl. 1), S46-S54.
[http://dx.doi.org/10.1016/j.ajic.2006.05.228] [PMID: 16813982]
[4]
(a)Siddiqi, Z.A.; Khalid, M.; Kumar, S.; Shahid, M.; Noor, S. Antimicrobial and SOD activities of novel transition metal complexes of pyridine-2,6-dicarboxylic acid containing 4-picoline as auxiliary ligand. Eur. J. Med. Chem., 2010, 45(1), 264-269.
[http://dx.doi.org/10.1016/j.ejmech.2009.10.005] [PMID: 19897283]
(b)Vibhute, P.K.; Dake, S.A.; Aghao, A.K.; Survase, S.A.; Dawane, B.S. Synthesis and Characterization of Cu(II), Mn(II) and Ni(II) Metal Complexes Derived from Schiff Bases of Furfuraldeyde, Amino Acids and their Methoxy Derivatives. J. Basic Appl. Sci., 2016, 12(12), 15-20.
(c)Sonnekar, V.S.; Jadhav, W.N.; Dake, S.A.; Dhole, S.G.; Narwade, S.S.; Pawar, R.P. Synthesis and Anti-Microbial Activities of some Thiourea Based Metal Complexes. Eur. Chem. Bull., 2014, 3(8), 792-797.
(d)Liu, Y.; Qin, R.; Zaat, S.A.J.; Breukink, E.; Heger, M. Antibacterial photodynamic therapy: overview of a promising approach to fight antibiotic-resistant bacterial infections. J. Clin. Transl. Res., 2015, 1(3), 140-167.
[PMID: 30873451]
[5]
Delaney, S.; Pascaly, M.; Bhattacharya, P.K.; Han, K.; Barton, J.K. Oxidative damage by ruthenium complexes containing the dipyridophenazine ligand or its derivatives: a focus on intercalation. Inorg. Chem., 2002, 41(7), 1966-1974.
[http://dx.doi.org/10.1021/ic0111738] [PMID: 11925195]
[6]
Eleni, K.E.; Yiannis, S.; Nikos, K.; Alexandra, K.; George, P. Transition metal complexes with the quinolone antibacterial agent pipemidic acid: Synthesis, characterization and biological activity. Polyhedron, 2007, 26(5), 1148-1158.
[http://dx.doi.org/10.1016/j.poly.2006.10.017]
[7]
Mark, E.; Volpin, N.; Galina, N.Yu.N.; Krainova, P.V.; Lapikova, A. Redox and fungicidal properties of phthalocyanine metal complexes as related to active oxygen. J. Inorg. Biochem., 2000, 81, 285-292.
[http://dx.doi.org/10.1016/S0162-0134(00)00114-8]
[8]
Gudasi, K.B.; Patil, M.S.; Vadavi, R.S.; Shenoy, R.V.; Patil, S.A.; Nethaji, M. X-Ray Crystal Structure of the N-(2-hydroxy-1-naphthalidene)phenylglycine Schiff Base. Synthesis and Characterization of Its Transition Metal Complexes. Chemistry and Materials Science, 2006, 31(5), 580-585.
[http://dx.doi.org/10.1007/s11243-006-0031-3]
[9]
Patel, K.C.; Goldberg, D.E. Aralkylpolyamine Complexes-III: Some Thiocyanate and Selenocyanate Com- plexes of Copper(II), Nickel(II) and Cobalt(II) with n-benzylethylenediamine and N,N′-dibenzylethylenediamine. J. Inorg. Nucl. Chem., 1972, 34(2), 637-649.
[http://dx.doi.org/10.1016/0022-1902(72)80444-5]
[10]
Abuhijleh, A.L.; Woods, C.; Ahmed, I.Y. Synthesis and Molecular Structure of Monomeric Copper(II) Acetates with 2-Methylimidazole and 1,2-Dimethylimida zole. Inorg. Chim. Acta, 1991, 190(1), 11-17.
[http://dx.doi.org/10.1016/S0020-1693(00)80226-1]
[11]
Angelusiu, M.V.; Barbuceanu, S.F.; Draghici, C.; Almajan, G.L. New Cu(II), Co(II), Ni(II) complexes with aroyl-hydrazone based ligand. Synthesis, spectroscopic characterization and in vitro antibacterial evaluation. Eur. J. Med. Chem., 2010, 45(5), 2055-2062.
[http://dx.doi.org/10.1016/j.ejmech.2010.01.033] [PMID: 20133023]
[12]
Singh, V.P.; Katiyar, A. Synthesis, spectral characterization and antimicrobial activity of some transition metal(II) complexes with acetone p-aminoacetophenone benzoylhydrazone. Pestic. Biochem. Physiol., 2008, 92(1), 8-14.
[http://dx.doi.org/10.1016/j.pestbp.2008.04.003]
[13]
Singh, D.P.; Kumar, R.; Malik, V.; Tyagi, P. Synthesis and Characterization of Complexes of Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) with Macrocycle 3,4,11,12-Tetraoxo-1,2,5,6,9,10,13,14-octaazacyclohexadeca- 6,8, 14,16-tetraene and Their Biological Screening. Transi- tion Metal Chemistry.,. 2007, 32(8), 1051-1055.
[14]
Refat, M.S.; El-Hawary, W.F.; Moussa, M.A.I.R. 1H NMR, mass, XRD and TGA/DTA investigations on the ciprofloxacin/iodine charge-transfer complex. Spectrochim. Acta A Mol. Biomol. Spectrosc., 2011, 78(5), 1356-1363.
[http://dx.doi.org/10.1016/j.saa.2011.01.010] [PMID: 21317025]
[15]
Zhang, Y.N.; Wang, H.; Liu, J.Q.; Wang, Y.Y.; Fu, A.Y.; Shi, Q.Z. Novel silver(I) compounds assembled from hybrid ligands based on linear or T-shaped coordination environment. Inorg. Chem. Commun., 2009, 12(7), 611-614.
[http://dx.doi.org/10.1016/j.inoche.2009.05.004]
[16]
Saxena, N.; Juneja, H.D.; Munshi, K.N. Synthesis, characterization and antimicrobial activity of a bivalent schiff base derived from salicylaldehyde and 4-methoxyaniline and its lanthanides (III) complexes. J. Indian Chem. Soc., 1993, 70, 943.
[17]
Suryawanshi, D.D.; Gaikwad, S.T.; Rajbhoj, A.S. Efficient ultrasound synthesis, characterization and biological screening of novel cyclic β-diketones. Chem. Sci. Trans., 2014, 3(1), 117-122.
[18]
Turel, I. The interactions of metal ions with quinolone antibacterial agents. Coord. Chem. Rev., 2002, 232(1-2), 27-47.
[http://dx.doi.org/10.1016/S0010-8545(02)00027-9]
[19]
Scully, B.E.; Nakatomi, M.; Ores, C.; Davidson, S.; Neu, H.C. Ciprofloxacin therapy in cystic fibrosis. Am. J. Med., 1987, 82(4A), 196-201.
[PMID: 3555036]
[20]
López-Gresa, M.P.; Ortiz, R.; Perelló, L.; Latorre, J.; Liu-González, M.; García-Granda, S.; Pérez-Priede, M.; Cantón, E. Interactions of metal ions with two quinolone antimicrobial agents (cinoxacin and ciprofloxacin). Spectroscopic and X-ray structural characterization. Antibacterial studies. J. Inorg. Biochem., 2002, 92(1), 65-74.
[http://dx.doi.org/10.1016/S0162-0134(02)00487-7] [PMID: 12230989]
[21]
Saha, S.; Dhanasekaran, D.; Chandraleka, S.; Thajuddin, N.; Panneerselvam, A. Synthesis, Characterization and Antimicrobial Activity of Cobalt Metal Complex Against Drug Resistant Bacterial and Fungal Pathogens. Adv. Biol. Res., 2010, 4(4), 224-229.

Rights & Permissions Print Cite
Article Metrics
10
1
© 2024 Bentham Science Publishers | Privacy Policy