Background: Microfluidics is becoming increasingly of interest as a superior
technique for the synthesis of nanoparticles, particularly for their use in nanomedicine. In
microfluidics, small volumes of liquid reagents are rapidly mixed in a microchannel in a
highly controlled manner to form nanoparticles with tunable and reproducible structure
that can be tailored for drug delivery. Both polymer and lipid-based nanoparticles are utilized
in nanomedicine and both are amenable to preparation by microfluidic approaches.
Aim: Therefore, the purpose of this review is to collect the current state of knowledge on
the microfluidic preparation of polymeric and lipid nanoparticles for pharmaceutical applications,
including descriptions of the main synthesis modalities. Of special interest are the
mechanisms involved in nanoparticle formation and the options for surface functionalisation
to enhance cellular interactions.
Conclusion: The review will conclude with the identification of key considerations for the
production of polymeric and lipid nanoparticles using microfluidic approaches.