In the literature screening, aquaporins were found in the cerebral structures including the pia
mater, choroid plexus, ependyma, piriform cortex, hippocampus, dorsal thalamus, supraoptic and
suprachiasmatic nuclei, white matter and subcortical organ. Among these, the most common are
AQP1, AQP4, and AQP9. The roles of aquaporins have been demonstrated in several diseases such as
cerebral edema, various central nervous system tumors, Alzheimer’s Disease and epilepsy. In this
review, the relationship between brain/brain-injury and aquaporin, has been reviewed.