Stem Cells from Human Exfoliated Deciduous Teeth (SHED) originate from the embryonic
neural crest as ectodermal mesenchymal stem cells and are isolated from human deciduous teeth.
SHED expresses the same cell markers as Embryonic Stem Cells (ESCs), such as OCT4 and NANOG,
which make SHED to have a significant impact on clinical applications. SHED possess higher rates of
proliferation, higher telomerase activity, increased cell population doubling, form sphere-like clusters,
and possess immature and multi-differentiation capacity; such high plasticity makes SHED one of the
most popular sources of stem cells for biomedical engineering. In this review, we describe the isolation
and banking method, the current development of SHED in regenerative medicine and tissue engineering
in vitro and in vivo.