Background: The treatment of multiple-drug-resistant tuberculosis (MDR-TB) with currently
available marketed drugs remains a global health concern. The cases of resistant tuberculosis
patients are increasing day by day.
Objective: The objective of this study is to highlight the need of developing shorter, simpler and
tolerable drug regimens.
Methods: In the present study, we synthesized various halo-substituted 2-aryloxyacetohydrazones
via a series of reactions from halo-substituted phenols. All the compounds were characterized by
using various spectroscopic methods, such as NMR, FT-IR, UV spectroscopy, etc.
Results: All the synthesized hydrazones showed theoretically good interactions with enzyme enoyl
reductase (pdb id: 4tzk). All the synthesized compounds (5a-5o) showed moderate to good activity
(3.125-100 μg/mL) against Mycobacteria tuberculosis, H37RV strain.
Conclusion: Our results would pave a new way for the development of more effective Anti-TB
agents in the future.