Background: Mycobacterium tuberculosis is a causative organism of tuberculosis,
which is the most deadly disease after cancer in the current decade. The development of multidrug
and broadly drug- resistant strains makes the tuberculosis problem more and more critical. In the last
40 years, only one molecule is added to the treatment regimen. Generally, drug design and development
programs are targeted proteins whose function is known to be essential to the bacterial cell.
Objectives: Here are the development of 'S', 'N’ heterocycles as antimycobacterials targeting fatty
acid biosynthesis are reported.
Materials and Methods: In the present communication, rational development of anti-mycobacterial
agent's targeting fatty acid biosynthesis has been done by integrating the pocket modeling and virtual
Results: The identified potential 33 lead compounds were synthesized, characterized by physicochemical
and spectroscopic methods like IR, NMR spectroscopy and further screened for antimycobacterial
activity using isoniazid as standard. All the designed compounds have shown profound
Conclusion: In this present communication, we found that 3c, 3f, 3l and 4k molecules had expressive
desirable biological activity and specific interactions with fatty acids. Further optimization of
these leads is necessary for the development of potential antimycobacterial drug candidates having
fewer side effects.