Login Register Cart 0
Generic placeholder image

Recent Patents on Biotechnology

Editor-in-Chief

ISSN (Print): 1872-2083
ISSN (Online): 2212-4012

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Evolution of World and Brazilian Markets for Enzymes Produced by Solid-state Fermentation: A Patent Analysis

Author(s): Heb C.S.R. Rodrigues, Andrea L. Carvalho, Carolina O. Souza and Marcelo A. Umsza-Guez*

Volume 14, Issue 2, 2020

Page: [112 - 120] Pages: 9

DOI: 10.2174/1872208313666191017143845

Price: $65

Abstract

Background: The use of enzymes in various industrial processes has become increasingly frequent. When added to productive processes, it can accelerate reactions and generate a number of new products. The solid state fermentation (SSF), among other applications, has been employed also to obtain enzymes.

Objective: The purpose of this prospection was to map registered patent documents about enzymes production by this type of fermentation in the world, identify the most obtained enzymes with patent documents and compilate information about the world and Brazilian enzyme markets.

Methods: The experimental design was carried out by the keyword-driven scope through the advanced search in the Espacenet database European Patent Office (EPO). The keywords selected were solid-state fermentation and the International Patent Classification code, C12N9 (enzymes; proenzymes), for prospecting of interest.

Results: In 2012, there was the higher number of registered patents (12). China holds 84% of deposited patents. Among the types of depositors, 54% of the selected patent documents were deposited by universities and institutes, and 44% by companies. 76.5% of the evaluated patents used fungi as enzyme producer. Analyzing the enzymes obtained in the registered patents, it is verified that the majority belongs to the group of carbohydrases with 43%, followed by proteases (25%), which are also the two classes of enzymes most commercialized in the market.

Conclusion: China holds the majority of the registered patents but North America gets the largest global enzyme market revenue followed by Europe and Pacific Asia. Carbohydrases were the most commercialized enzymes and with the highest number of patents registered. Among the carbohydrases, cellulases, xylanases and amylases are the most frequent in patent registration while being fungi produced.

Keywords: Enzymes, patent, SSF, carbohydrases, C12N9, cellulases.

Next »
Graphical Abstract

[1]
Nelson DL, Cox MM. Principles of Biochemistry. 4th ed. USA: W. H. Freeman 2004.
[2]
Pandey A. Enzyme technology INC. New Delhi: Springer, Asiatech Publishers 2005.
[3]
Singh R, Kumar M, Mittal A, Mehta PK. Microbial enzymes: industrial progress in 21st century. 3 Biotech 2016; 6: 1-15.
[4]
Singhania RR, Patel AK, Soccol CR, Pandey A. Re-cent advances in solid-state fermentation. Biochem Eng J 2009; 44: 13-8.
[http://dx.doi.org/10.1016/j.bej.2008.10.019]
[5]
Abrunhosa L, Venâncio A, Teixeira JA. Optimization of process parameters for the production of an OTA-hydrolyzing enzyme from Aspergillus niger under solid-state fermentation. J Biosci Bioeng 2011; 112(4): 351-5.
[http://dx.doi.org/10.1016/j.jbiosc.2011.06.016] [PMID: 21778112]
[6]
Rodriguez-Couto S, Sanroman MA. Application of solid-state fermentation to food industry - A review. J Food Eng 2006; 73: 291-302.
[http://dx.doi.org/10.1016/j.jfoodeng.2005.05.022]
[7]
Soccol CR, Da Costa ESF, Letti LAJ, Karp SG, Woiciechowski AL, Vandenberghe LPS. Recent de-velopments and innovations in solid state fermenta-tion. Biotechnol Res Innov 2017; 1: 52-71.
[http://dx.doi.org/10.1016/j.biori.2017.01.002]
[8]
Thomas L, Larroche C, Pandey A. Current develop-ments in solid-state fermentation. Biochem Eng J 2013; 81: 146-61.
[http://dx.doi.org/10.1016/j.bej.2013.10.013]
[9]
Martins S, Mussatto SI, Martínez-Avila G, Montañez-Saenz J, Aguilar CN, Teixeira JA. Bioactive phenolic compounds: production and extraction by solid-state fermentation. A review. Biotechnol Adv 2011; 29(3): 365-73.
[http://dx.doi.org/10.1016/j.biotechadv.2011.01.008] [PMID: 21291993]
[10]
Sandri IG, da Silveira MM. Production and applica-tion of pectinases from Aspergillus niger obtained in solid state cultivation. Beverages 2018; 4: 48.
[http://dx.doi.org/10.3390/beverages4030048]
[11]
Ashok A, Doriya K, Rao DRM, Kumar DS. Design of solid state bioreactor for industrial applications: an overview to conventional bioreactors. Biocatal Agric Biotechnol 2017; 9: 11-8.
[http://dx.doi.org/10.1016/j.bcab.2016.10.014]
[12]
Sánchez DA, Tonetto GM, Ferreira ML. Burkholderia cepacia lipase: A versatile catalyst in synthesis reactions. Biotechnol Bioeng 2018; 115(1): 6-24.
[http://dx.doi.org/10.1002/bit.26458] [PMID: 28941272]
[13]
Piedrahíta-Aguirre CA, Bastos RG, Carvalho AL, Monte Alegre R. The influence of process parameters in production of lipopeptide iturin A using aerated packed bed bioreactors in solid-state fermentation. Bioprocess Biosyst Eng 2014; 37(8): 1569-76.
[http://dx.doi.org/10.1007/s00449-014-1129-1] [PMID: 24504698]
[14]
Pandey A. Solid-state fermentation. Biochem Eng J 2003; 13: 81-4.
[http://dx.doi.org/10.1016/S1369-703X(02)00121-3]
[15]
Enzymes Market By Type (Industrial, Specialty), By Product (Carbohydrases, Proteases, Lipases, Polymerases & Nucleases), By Application (Food & Beverages, Detergents, Animal Feed, Textile, Paper & Pulp, Nutraceutical, Personal Care & Cosmetics, Wastewater, Research & Biotechnology, Diagnostics, Biocatalyst) And Segment Forecasts To 2024 Published in jun 2016, nº978-1-68038-022-4 Available on: https://www.grandviewresearch.com/industry-analysis/industrial-enzymes-market2017 Acessed on april 19, 2017;
[16]
Industrial Enzymes Market Analysis By Product (Carbohydrase, Lipases, Proteases, Polymerases & Nucleases and Others), By Application (Textile, Feed Additive and Food Processing), By End-Use (Food & Beverage, Detergents, Animal Feed, Textile, Paper & Pulp, Nutraceutical, Personal Care & Cosmetics, and Wastewater) And Segment Forecasts To 2024 Published in may 2016, nº 978-1-68038-844-2 Available on: https://www.grandviewresearch.com/industry-analysis/industrial-enzymes-market2017 Acessed on april 7, 2017;
[17]
Grand View Research, Enzymes Market Size, Share & Trends Analysis Report By Product (Carboydrases, Proteases, Lipases), By Application (Industrial, Specialty), By End Use, By Region, And Segment Forecasts, 2019 - 2025 Published in Jun 2019 Available on: 2019 https://www.grandviewresearch.com/Indus-try-analysis/enzymes-industry
[18]
Mordor Intelligence, North America industrial enzymes market - growth, trends, and forecast (2017-2022) Published in 2019 Available on: 2019. https://www.mordorintelligence.com/industry-reports/north-america-industrial-enzymes-market-industry
[19]
Market Data Forecast, North America Food Enzymes Market By Type (Carbohydrase, Protease, Lipase), Application (Beverage, Processed Food, Dairy, Bakery, Confectionery), Source (Plant, Microorganism, Animal), Form (Lyophilized Powder, Liquid), & By Region - Industry Analysis, Size, Share, Growth, Trends, And Forecasts (2018-2023) Published in Oct 2018 Available on: 2018. https://www.marketdata-forecast.com/market-reports/north-america-food-enzymes-market
[20]
BRASIL Sistema de Análise de Informações de Comércio Exterior - AliceWeb, Departamento de Comércio Exterior, Ministério do Desenvolvimento, Indústria e Comércio Exterior Available from: http://www.mdic.gov.br/comercio-exterior/estatisticas -de-comercio-exterior/2017
[21]
Production of pyrogen-free penicil-linase. GB887408 1962.
[22]
Shinmen Y, Asami S, Amano N, Amachi T, Yoshi-zumi H. Production of peroxidase. JPS61104784 1986.
[23]
Zhang X. Process for preparing pectinase by solidstate fermentation of fruit or vegetable dregs. CN1271774, 2000.
[24]
Ding YW. Preparation method of solid-state machinery fermentation xylanase. CN1920016 (A), 2007.
[25]
Yaoxing X, Yanli L, Shaochun X, Xiaohui L. Aspergillus zryzae strain capable of highly producing neutral proteinase and fermentation method thereof on solid state substrate. CN101144060 (A), 2008.
[26]
Xiao YS. Method for producing laccase using Trametes AH28-2 solid fermentation. CN1807606 (A), 2006.
[27]
Dehai L, Hongyun W, Guoshen C, Yiliang H, Xian-gyu P. Method for preparing beta-glucanase for feeding by utilizing solid-state fermentation of peanut hull meal. CN102242091 (A), 2011.
[28]
Rong J, Juntao Y. Manganese peroxidase solid state fermentation substrate, preparation thereof and application method. CN102634494 (A), 2012.
[29]
Wang S, Chen L, Su E. Solid state fermentation production method for beta-D-fructofuranosidase. CN103045561 (A), 2013.
[30]
Are patents indicative of Chinese innovation? China Power February 15, 2016 Updated April 19, 2019 2019 Accessed August 23, 2019; https://chinapower. csis.org/patents/
[31]
China Drives International Patent Applications to Record Heights; Demand Rising for Trademark and Industrial Design Protection Geneva 2018. https://www.wipo.int/pressroom/en/articles/2018/article_0002.html
[32]
Contesini FJ, de Alencar FJ, Kawaguti HY, et al. Potential applications of carbohydrases immobilization in the food industry. Int J Mol Sci 2013; 14(1): 1335-69.
[http://dx.doi.org/10.3390/ijms14011335] [PMID: 23344046]
[33]
Singh R, Mittal A, Kumar M, Mehta PK. Microbial proteases in commercial applications. J Pharm Chem Biol Sci 2016; 4(3): 365-74.
[34]
Xu FJ. Applications of oxidoreductases: recent pro-gress. Ind Biotechnol (New Rochelle NY) 2005; 1(1)
[http://dx.doi.org/10.1089/ind.2005.1.38]
[35]
Beniwal V, Kumar A, Sharma J, Chhokar V. Recent advances in industrial application of tannases: a review. Recent Pat Biotechnol 2013; 7(3): 228-33.
[http://dx.doi.org/10.2174/18722083113076660013] [PMID: 24182319]

Rights & Permissions Print Cite
Article Metrics
42
2
© 2024 Bentham Science Publishers | Privacy Policy