Background: Nanoparticles are in the forefront of research due to their unique properties
that find possible applications from optoelectronics to medical technology. It is also reported that nanoparticles
can interact with the living cells and can selectively destroy the cells. Researchers are thus
interested to find a way by which the drugs will be attached to the nanoparticles, go to the target site
and destroy the infected cells. Before that, it is very much important to understand the interaction of
nanoparticles with the blood, plasma and other biological cells that exists in the blood. It is also very
essential to understand how the nanoparticles interact with the absorbed sucrose in the cell.
Objective: Our objective in this research is to investigate the interaction of ZnO nanoparticles with sucrose
and honey sugar to understand the basic interaction mechanism. It will also enable us to find a
way of stabilizing body sucrose and glucose level.
Methods: We have followed a simple chemical synthesis method to prepare ultrafine ZnO nanoparticles.
Then the interaction of ZnO nanoparticles with sucrose and honey sugar was investigated as a
function of time using UV-visible spectroscopy to understand the basic interaction mechanism.
Results: Well grown ZnO nanoparticles were found to form of crystallite size ~38 nm. The band gap was
calculated from the absorption spectra and was found to be ~ 3.9 eV. This band gap enhancement indicates
that the sizes of the nanoparticles are very small. The decrease of absorption with time indicates that
the ZnO nanoparticles interact with the sugar molecule. Sucrose molecules are polar. Hence there is electrostatic
attraction between the sucrose molecules and ZnO molecules resulting in the sucrose-ZnO composite
system. On increasing the interaction time more and more sucrose molecules will cover the ZnO
nanoparticles by forming ZnO-sucrose corona. The interaction time constant i.e., the binding time of sucrose
molecule with the surface of ZnO nanoparticles, t1 was found to be 27.7127 min and is 29.59 min
for honey. The results indicate an association process to form corona of ZnO nanoparticles with sucrose
and honey molecules.
Conclusion: We have successfully synthesized ultrafine ZnO nanoparticles of high band gap. The
synthesized nanoparticles interact with the sucrose and honey molecules and form corona. This study
is very important in understanding the interaction mechanism on nanoparticles with the biomolecules
for possible drug delivery applications.