Extracellular vesicles (EVs) are gaining tremendous importance in comprehending central nervous
system (CNS) function and treating neurological disorders because of their role in intercellular communication
and reparative processes, and suitability as drug delivery vehicles. Since EVs have lipid membranes, they cross
the blood-brain barrier easily and communicate with target neurons and glia even deep inside the brain. EVs from
various sources have been isolated, characterized, and tailored for promoting beneficial effects in conditions, such
as brain injury and disease. Particularly, EVs isolated from mesenchymal stem cells and neural stem cells have
shown promise for alleviating brain dysfunction after injury or disease. Such properties of stem cell-derived EVs
have great importance for clinical applications, as EV therapy can avoid several concerns typically associated
with cell therapy. This minireview confers the competence of EVs for improving brain function by modulating
CNS injury and disease.
Keywords: Brain injury, extracellular vesicles, exosomes, mesenchymal stem cells, neural stem cells, neurodegenerative diseases.
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