Title:Coexistence of Hodgkin and Non-Hodgkin Lymphoma; Composite Lymphoma [CL] in a Patient Presenting with Waxing and Waning Lymphadenopathy
VOLUME: 20 ISSUE: 2
Author(s):Eleni Geladari, Georgia Dimopoulou, Evangelia Margellou, Andreas Paraskevas, Georgios Kafetzis, Dimitra Rontogianni and Maria Vadiaka*
Affiliation:1st Internal Medicine Department, Evaggelismos General Hospital, Athens, 1st Internal Medicine Department, Evaggelismos General Hospital, Athens, 1st Internal Medicine Department, Evaggelismos General Hospital, Athens, Pathology Department, Evaggelismos General Hospital, Athens, 4th Surgical Department, Evaggelismos General Hospital, Athens, Pathology Department, Evaggelismos General Hospital, Athens, 1st Internal Medicine Department, Evaggelismos General Hospital, Athens
Keywords:Waxing and waning lymphadenopathy, composite lymphoma, Hodgkin lymphoma, Non-Hodgkin lymphoma,
malignancies, castleman disease.
Abstract:
Background: The coexistence of two or more types of lymphoma within the same
organ at the same time of diagnosis is defined as composite lymphoma, a rare disease that has
recently been identified in the literature. Pointedly, the concurrence may be Hodgkin lymphoma
with a Non-Hodgkin lymphoma [NHL], either B or T cells, or two different entities of NHLs.
Furthermore, this condition has been described concurrently or sequentially. In order for the
diagnosis to be established, two or more distinct clones should be proven by morphological and
laboratory tests.
Case Presentation: Herein, we cite a seventy-three-year old female patient with low-grade fever,
waxing and waning cervical lymphadenopathy, whose biopsy of an axillary lymph node demonstrated
the rare coexistence of Hodgkin and NHL, known as composite lymphoma.
Conclusion: Composite lymphomas pose a particular diagnostic challenge, and currently, there are
no agreed standards for treatment.
