Epigenetic Effects Mediated by Antiepileptic Drugs and their Potential Application

Author(s): Fan-Cheng Kong, Chun-Lai Ma*, Ming-Kang Zhong

Journal Name: Current Neuropharmacology

Volume 18 , Issue 2 , 2020

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Graphical Abstract:


Abstract:

An epigenetic effect mainly refers to a heritable modulation in gene expression in the short term but does not involve alterations in the DNA itself. Epigenetic molecular mechanisms include DNA methylation, histone modification, and untranslated RNA regulation. Antiepileptic drugs have drawn attention to biological and translational medicine because their impact on epigenetic mechanisms will lead to the identification of novel biomarkers and possible therapeutic strategies for the prevention and treatment of various diseases ranging from neuropsychological disorders to cancers and other chronic conditions. However, these transcriptional and posttranscriptional alterations can also result in adverse reactions and toxicity in vitro and in vivo. Hence, in this review, we focus on recent findings showing epigenetic processes mediated by antiepileptic drugs to elucidate their application in medical experiments and shed light on epigenetic research for medicinal purposes.

Keywords: Antiepileptic drug, DNA methylation, histone modification, untranslated RNA, molecular mechanism, application.

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